In-body power source having high surface area electrode

Patent metadata

Field	Value
Publication number	US-11464423-B2
Application number	US-201514602895-A
Country	US
Kind code	B2
Filing date	Jan 22, 2015
Priority date	Feb 14, 2007
Publication date	Oct 11, 2022
Grant date	Oct 11, 2022

Abstract

Power sources that enable in-body devices, such as implantable and ingestible devices, are provided. Aspects of the in-body power sources of the invention include a solid support, a first high surface area electrode and a second electrode. Embodiments of the in-power sources are configured to emit a detectable signal upon contact with a target physiological site. Also provided are methods of making and using the power sources of the invention.

First claim

What is claimed is:

1. An in-body medical device comprising:
an integrated circuit substrate comprising a surface and a circuitry element;
a first electrode coupled to the circuitry element and comprising:
a first active electrode material;
a first surface; and
a second surface;

a second electrode connected to the surface of the integrated circuit substrate and coupled to the circuitry element, wherein the second electrode is electrically isolated from the first electrode and comprises a second active electrode material that is different from the first active electrode material; and
an electrically conductive porous under-layer interposed between the first surface of the first electrode and the surface of the integrated circuit substrate, the electrically conductive porous under-layer comprising an inert metal or an oxidizable metal; wherein the electrically conductive porous under-layer is configured to provide a surface area enhancement to the first electrode, wherein the electrically conductive porous under-layer is configured to improve adhesion, and wherein the electrically conductive porous under-layer is a layer that is contiguous to and mechanically supports the first electrode; and
wherein the in-body medical device is suitable for human ingestion or implantation.

2. The in-body medical device according to claim 1 , wherein the device is dimensioned to be ingestible.

3. The in-body medical device according to claim 1 , wherein the electrically conductive porous under-layer comprises an element selected from the group consisting of: Au, Cu, Pt, Ir, Pd, Rh and Ru and alloys thereof.

4. The in-body medical device according to claim 1 , wherein the electrically conductive porous under-layer comprises an element selected from the group consisting of: Ti and W and alloys thereof.

5. The in-body medical device according to claim 1 , wherein the electrically conductive porous under-layer has a thickness ranging from 0.1 to 100 μm.

6. The in-body medical device according to claim 1 , wherein the first electrode is formed on the same surface of the integrated circuit substrate as the second electrode.

7. The in-body medical device according to claim 1 , wherein:
the surface of the integrated circuit substrate comprises a first substrate surface to which the first electrode is connected via the electrically conductive porous under-layer and a second substrate surface to which the second electrode is connected; and
the first substrate surface is arranged opposite to the second substrate surface.

8. The in-body medical device according to claim 1 , wherein the device comprises a pharmaceutically acceptable carrier composition.

9. The in-body medical device according to claim 8 , wherein the pharmaceutically acceptable carrier composition is in the form of a tablet.

10. The in-body medical device according to claim 8 , wherein the pharmaceutically acceptable carrier composition is in the form of a capsule.

11. The in-body medical device according to claim 8 , wherein the pharmaceutically acceptable carrier composition comprises an active agent.

12. The device of claim 1 , wherein the second surface is uncovered by the electrically conductive porous under-layer.

13. A system comprising:
a receiver; and
an in-body medical device suitable for human ingestion or implantation, wherein the in- body medical device is configured to communicate with the receiver, the in-body medical device comprising:
an integrated circuit substrate comprising a surface and a circuitry element;
a first electrode coupled to the circuitry element and comprising:
a first active electrode material;
a first surface; and
a second surface;

a second electrode connected to the surface of the integrated circuit substrate and coupled to the circuitry element, wherein the second electrode is electrically isolated from the first electrode and comprises a second active electrode material that is different from the first active electrode material; and

an electrically conductive porous under-layer interposed between the first surface of the first electrode and the surface of the integrated circuit substrate, the electrically conductive porous under-layer comprising an inert metal or an oxidizable metal; wherein the electrically conductive porous under-layer is configured to provide a surface area enhancement to the first electrode, wherein the electrically conductive porous under-layer is configured to improve adhesion, and wherein the electrically conductive porous under-layer is a layer that is contiguous to and mechanically supports the first electrode.

14. The system according to claim 13 , wherein said receiver is an in vivo receiver.

15. The system according claim 13 , wherein said receiver is an ex vivo receiver.

16. The system according to claim 13 , wherein the electrically conductive porous under-layer is provided by electrodeposition.

17. The system according to claim 13 , wherein the electrically conductive porous under-layer is provided by cathodic arc deposition.

18. The system according to claim 13 , wherein the electrically conductive porous under-layer is provided by electrophoretic deposition.

19. The system of claim 13 , wherein the second surface is uncovered by the electrically conductive porous under-layer.

Assignees

• Otsuka Pharma Co Ltd

Inventors

• Hafezi Hooman
• Robertson Timothy
• Snyder Eric
• Cozad Brad

Classifications

• A61P23/00

  Anaesthetics · CPC title

• A61B5/0028

  Body tissue as transmission medium, i.e. transmission systems where the medium is the human body · CPC title

• C25D13/02

  with inorganic material · CPC title

• A61B2560/0214

  of power generation or supply · CPC title

• H01M4/02

  Electrodes composed of, or comprising, active material · CPC title