Sensor device and detection apparatus

Patent metadata

Field	Value
Publication number	US-11459537-B2
Application number	US-201816632111-A
Country	US
Kind code	B2
Filing date	Apr 19, 2018
Priority date	Jul 19, 2017
Publication date	Oct 4, 2022
Grant date	Oct 4, 2022

Abstract

A sensor device according to the present technology includes a stack sensor. The stack sensor includes a first sensor layer and a second sensor layer. The first sensor layer has, as a detection target, a first substrate in a culture solution, the first substrate being changed in accordance with a change in a state of a cell. The second sensor layer has, as a detection target, a second substrate in the culture solution and is provided on the first sensor layer, the second substrate being changed in accordance with the change in the state.

First claim

The invention claimed is:

1. A sensor device, comprising:
a plurality of stack sensors provided on a support substrate at predetermined intervals, wherein the plurality of stack sensors include:
a first sensor layer that has, as a first detection target, a first substrate in a culture solution, the first substrate being changed in accordance with a change in a state of a cell,
a second sensor layer that has, as a second detection target, a second substrate in the culture solution, the second substrate being changed in accordance with the change in the state of the cell, and
a third sensor layer that has, as a third detection target, a third substrate in the culture solution, the third substrate being changed in accordance with the change in the state of the cell, and

wherein the plurality of stack sensors include:
a first stack sensor with the first sensor layer and the third sensor layer adjacent to each other and aligned in a first XY direction, with the second sensor layer provided across both of the first sensor layer and the third sensor layer, and
a second stack sensor with the second sensor layer and the third sensor layer adjacent to each other and aligned in the first XY direction, with both the second sensor layer and the third sensor layer provided across the first sensor layer.

2. The sensor device according to claim 1 , wherein
the first sensor layer contains a first optically active substance that reacts with the first substrate,
the second sensor layer contains a second optically active substance that reacts with the second substrate, and
the third sensor layer contains a third optically active substance that reacts with the third substrate.

3. The sensor device according to claim 2 , wherein
the first sensor layer contains the first optically active substance that reacts with oxygen being the first substrate,
the second sensor layer contains the second optically active substance that reacts with a hydrogen ion being the second substrate, and
the third sensor layer contains the third optically active substance that reacts with the third substrate that is different than the first substrate and the second substrate.

4. The sensor device according to claim 3 , wherein
the first sensor layer contains platinum porphyrin as the first optically active substance, and
the second sensor layer contains fluorescein as the second optically active substance.

5. A detection apparatus, comprising a sensor device according to claim 1 ;
a light source that applies light to the plurality of stack sensors; and
a detection unit that detects light that has been transmitted through the plurality of stack sensors.

Assignees

• Sony Corp

Inventors

• Takemura Ichiro
• Yamaguchi Daisuke
• Goto Yoshio
• YOSHIMITSU Kyohei

Classifications

• G01N2021/7786

  Fluorescence · CPC title

• G01N21/77 Primary

  by observing the effect on a chemical indicator · CPC title

• C12M25/00

  Means for supporting, enclosing or fixing the microorganisms, e.g. immunocoatings · CPC title

• C12M41/46

  of cellular or enzymatic activity or functionality, e.g. cell viability · CPC title

• C12M41/36

  of biomass, e.g. colony counters or by turbidity measurements (electrooptical investigation of individual particles G01N15/14, flow cytometers G01N15/1404) · CPC title