Antagonists of IL-6 to prevent or treat cachexia, weakness, fatigue, and/or fever
US-2015273058-A1 · Oct 1, 2015 · US
US11458178B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-11458178-B2 |
| Application number | US-201816765070-A |
| Country | US |
| Kind code | B2 |
| Filing date | Nov 26, 2018 |
| Priority date | Nov 24, 2017 |
| Publication date | Oct 4, 2022 |
| Grant date | Oct 4, 2022 |
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The present invention provides a novel IL-1β and/or IL-6 expression inhibitor and use thereof. The IL-1β and/or IL-6 expression inhibitor in accordance with an aspect of the present invention contains a component derived from alcoholic fermentation lees.
Opening claim text (preview).
What is claimed is: 1. A method for alleviating fatigue caused by brain inflammation, said method comprising the step of: administering, to a human or a non-human animal, an anti-fatigue composition comprising a component derived from alcoholic fermentation lees, wherein the component derived from alcoholic fermentation lees is a water extract of the alcoholic fermentation lees or a re-fermented product obtained by fermenting the alcoholic fermentation lees at least once by lactic acid fermentation and/or alcoholic fermentation. 2. A method for alleviating fatigue caused by brain inflammation, said method comprising the step of: administering, to a human or a non-human animal, a food or beverage composition comprising a component derived from alcoholic fermentation lees, wherein the component derived from alcoholic fermentation lees is a water extract of the alcoholic fermentation lees or a re-fermented product obtained by fermenting the alcoholic fermentation lees at least once by lactic acid fermentation and/or alcoholic fermentation. 3. The method according to claim 1 , wherein the brain inflammation is caused by expression of IL-1β and/or IL-6. 4. The method according to claim 3 , wherein the component derived from alcoholic fermentation lees inhibits expression of IL-1β and/or IL-6. 5. The method according to claim 1 , wherein the alcoholic fermentation lees are sake lees. 6. The method according to claim 3 , wherein the alcoholic fermentation lees are sake lees. 7. The method according to claim 4 , wherein the alcoholic fermentation lees are sake lees. 8. The method according to claim 2 , wherein the brain inflammation is caused by expression of IL-1β and/or IL-6. 9. The method according to claim 8 , wherein the component derived from alcoholic fermentation lees inhibits expression of IL-1β and/or IL-6. 10. The method according to claim 2 , wherein the alcoholic fermentation lees are sake lees. 11. The method according to claim 8 , wherein the alcoholic fermentation lees are sake lees. 12. The method according to claim 9 , wherein the alcoholic fermentation lees are sake lees.
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