Methods for treating diseases and nerve injuries

Patent metadata

Field	Value
Publication number	US-11458122-B2
Application number	US-201816637295-A
Country	US
Kind code	B2
Filing date	Aug 8, 2018
Priority date	Aug 9, 2017
Publication date	Oct 4, 2022
Grant date	Oct 4, 2022

Abstract

Some embodiments of the invention include methods for treating an animal for disease or nerve damage, comprising administration of a composition comprising a myelination enhancing inhibitor to the animal. Other embodiments of the invention include methods for treating an animal for disease or nerve damage, comprising administration of a composition comprising an HDAC3 inhibitor to the animal. Still other embodiments of the invention include methods for treating an animal for MS or nerve damage, comprising administration of a composition comprising an HDAC3 inhibitor to the animal. Additional embodiments of the invention are also discussed herein.

First claim

What is claimed is:

1. A method for treating an animal for disease or nerve injury, comprising administration of a composition comprising a myelination enhancing inhibitor to the animal,
wherein
(a) the myelination enhancing inhibitor used for treatment is CUDC-907, Quisinostat, RG2833, CUDC-101, Resminostat, 4SC-202, Mocetinostat, Entinostat, Citarinostat, Abexinostat, Pracinostat, PDA106, CAY10398, chidamide, LAQ824, SAHA, GSK-J4, JIB-04, UNC0631, or UNC0646, and the disease or nerve injury is myelopathy, myelitis, vascular myelopathy, cervical spondylotic myelopathy, spondylosis, spinal stenosis, demyelinating disease, any disease of the nervous system where the myelin sheath of a neuron is damaged, CNS demyelinating disease, PNS demyelinating disease, genetic demyelinating disease, infectious demyelinating disease, autoimmune demyelinating disease, demyelinating myelinoclastic disease, demyelinating leukodystrophic disease, Devic's disease, CNS neuropathies, diseases resulting in vitamin B12 deficiency, central pontine myelinolysis, myelopathies, tabes dorsalis , leukoencephalopathies, progressive multifocal leukoencephalopathy, leukodystrophies, optic neuritis, transverse myelitis, neuromyelitis optica, Guillain-Barré syndrome, chronic inflammatory demyelinating polyneuropathy, anti-MAG peripheral neuropathy, Charcot-Marie-Tooth disease, Hereditary neuropathy with liability to pressure palsy, copper deficiency associated conditions, peripheral neuropathy, myelopathy, optic neuropathy, progressive inflammatory neuropathy, multiple sclerosis (MS), MS-type clinically isolated syndrome, relapsing-remitting MS, primary progressive MS, or secondary progressive MS; or
(b) the myelination enhancing inhibitor used for treatment is CUDC-907, Quisinostat, CUDC-101, Resminostat, 4SC-202, Mocetinostat, Entinostat, Citarinostat, Abexinostat, Pracinostat, RGFP966, CAY10398, chidamide, LAQ824, GSK-J4, JIB-04, UNC0631, or UNC0646, and the disease or nerve injury is spinal cord injury, traumatic brain injury, acquired brain injury, hypoxic ischemic brain injury, strokes, periventricular leukomalacia (PVL), white-matter brain injury, CNS nerve injury, PNS nerve injury, crush nerve injury, or transection nerve injury.

2. The method of claim 1 , wherein the myelination enhancing inhibitor used for treatment is CUDC-907, Quisinostat, RG2833, CUDC-101, Resminostat, 4SC-202, Mocetinostat, Entinostat, Citarinostat, Abexinostat, Pracinostat, PDA106, CAY10398, chidamide, LAQ824, SAHA, GSK-J4, JIB-04, UNC0631, or UNC0646, and the disease or nerve injury is myelopathy, myelitis, vascular myelopathy, cervical spondylotic myelopathy, spondylosis, spinal stenosis, demyelinating disease, any disease of the nervous system where the myelin sheath of a neuron is damaged, CNS demyelinating disease, PNS demyelinating disease, genetic demyelinating disease, infectious demyelinating disease, autoimmune demyelinating disease, demyelinating myelinoclastic disease, demyelinating leukodystrophic disease, Devic's disease, CNS neuropathies, diseases resulting in vitamin B12 deficiency, central pontine myelinolysis, myelopathies, tabes dorsalis , leukoencephalopathies, progressive multifocal leukoencephalopathy, leukodystrophies, optic neuritis, transverse myelitis, neuromyelitis optica, Guillain-Barré syndrome, chronic inflammatory demyelinating polyneuropathy, anti-MAG peripheral neuropathy, Charcot-Marie-Tooth disease, Hereditary neuropathy with liability to pressure palsy, copper deficiency associated conditions, peripheral neuropathy, myelopathy, optic neuropathy, progressive inflammatory neuropathy, multiple sclerosis (MS), MS-type clinically isolated syndrome, relapsing-remitting MS, primary progressive MS, or secondary progressive MS.

3. The method of claim 1 , wherein the myelination enhancing inhibitor used for treatment is CUDC-907, Quisinostat, CUDC-101, Resminostat, 4SC-202, Mocetinostat, Entinostat, Citarinostat, Abexinostat, Pracinostat, RGFP966, CAY10398, chidamide, LAQ824, GSK-J4, JIB-04, UNC0631, or UNC0646, and the disease or nerve injury is spinal cord injury, traumatic brain injury, acquired brain injury, hypoxic ischemic brain injury, strokes, periventricular leukomalacia (PVL), white-matter brain injury, CNS nerve injury, PNS nerve injury, crush nerve injury, or transection nerve injury.

4. The method of claim 1 , wherein the method comprises more than one administration of the composition comprising the myelination enhancing inhibitor to the animal.

5. The method of claim 1 , wherein the amount of the myelination enhancing inhibitor is from about 0.0001% (by weight total composition) to about 99%.

6. The method of claim 1 , wherein the composition further comprises a formulary ingredient.

7. The method of claim 1 , wherein the composition is a pharmaceutical composition.

8. The method of claim 1 wherein the administration comprises parenteral administration, mucosal administration, intravenous administration, depot injection, subcutaneous administration, topical administration, intradermal administration, oral administration, sublingual administration, intranasal administration, or intramuscular administration.

9. The method of claim 1 , wherein the administration comprises a depot injection or an oral administration.

10. The method of claim 1 , wherein if there is more than one administration at least one composition used for at least one administration is different from the composition of at least one other administration.

11. The method of claim 1 , wherein the myelination enhancing inhibitor of the composition is administered to the animal in an amount of from about 0.005 mg/kg animal body weight to about 100 mg/kg animal body weight.

12. The method of claim 1 , wherein the animal is a human, a rodent, or a primate.

13. The method of claim 1 , wherein the animal is in need of treatment of disease or nerve injury.

14. The method of claim 2 , wherein the method is for treating MS, MS-type clinically isolated syndrome, relapsing-remitting MS, primary progressive MS, or secondary progressive MS.

15. The method of claim 2 , wherein the method is for treating inflammation, remyelination, or both in MS, MS-type clinically isolated syndrome, relapsing-remitting MS, primary progressive MS, or secondary progressive MS.

16. The method of claim 2 , wherein the method is for treating CNS demyelinating disease, PNS demyelinating disease, or MS.

17. The method of claim 3 , wherein the method is for treating traumatic brain injury, acquired brain injury, hypoxic ischemic brain injury, strokes, periventricular leukomalacia (PVL), white-matter brain injury, CNS nerve injury, PNS nerve injury, crush nerve injury, or transection nerve injury.

18. The method of claim 3 , wherein the method is for treating CNS nerve injury, PNS nerve injury, crush nerve injury, or transection nerve injury.

19. The method of claim 1 , wherein the method further comprises one or more other treatments.

20. The method of claim 2 , wherein the myelination enhancing inhibitor is PDA106, RG2833, CAY10398, chidamide, LAQ824, SAHA, GSK-J4, JIB-04, UNC0631, or UNC0646.

21. The method of claim 3 , wherein the myelination enhancing inhibitor is CUDC-907, Quisinostat, CUDC-101, Resminostat, 4SC-202, Mocetinostat, Entinostat, Citarinostat, Abexinostat, Pracinostat, or RGFP966.

22. The method of claim 2 , wherein the method is for treating an animal for MS, comprising administration of a composition comprising PDA106 to the animal.

23. The

Assignees

• Childrens Hospital Med Ct

Inventors

• He Xuelian
• Lu Qing
• Zhang Liguo

Classifications

• A61P25/28

  for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia · CPC title

• A61K31/4353

  ortho- or peri-condensed with heterocyclic ring systems · CPC title

• A61K31/415 Primary

  1,2-Diazoles · CPC title

• A61P25/02

  for peripheral neuropathies · CPC title

• A61K45/06

  Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca · CPC title