Methods and Related Kits for Treating and Regenerating Tooth Pulp and Periapical Tissues in a Mammal
US-2018161394-A1 · Jun 14, 2018 · US
US11457996B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-11457996-B2 |
| Application number | US-201916568909-A |
| Country | US |
| Kind code | B2 |
| Filing date | Sep 12, 2019 |
| Priority date | Sep 12, 2019 |
| Publication date | Oct 4, 2022 |
| Grant date | Oct 4, 2022 |
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The invention relates to the application of a composition containing recombinant amelogenin and propylene glycol alginate (“PGA”) on to cut dentin tubules followed by installation of a definitive restorative in a single visit.
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The invention claimed is: 1. A method for capping a damaged tooth having exposed dental pulp, comprising: applying a composition consisting of an aqueous vehicle, amelogenin and propylene glycol alginate (“PGA”) to a surface of the exposed dental pulp of the damaged tooth; wherein the amelogenin comprises an amino acid sequence that is identical to the amino acid sequence of SEQ ID NO: 2; wherein the amelogenin is present at a concentration of from 20 to 50 mg/cc in the aqueous vehicle; wherein the aqueous vehicle has a pH of 5.5; and applying a permanent dental restorative on top of the applied composition consisting of the aqueous vehicle, the amelogenin and the propylene glycol alginate; wherein applying the composition to the surface of the exposed dental pulp of the damaged tooth forms a tertiary dentine mineralized barrier that seals the exposed dental pulp inside the damaged tooth. 2. The method of claim 1 , wherein the composition contains from 20 to 40 mg of amelogenin per ml of the aqueous vehicle.
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