Biodegradable amphiphilic shape memory polymers and compositions and methods thereof

Patent metadata

Field	Value
Publication number	US-11453746-B2
Application number	US-202017034051-A
Country	US
Kind code	B2
Filing date	Sep 28, 2020
Priority date	Dec 2, 2016
Publication date	Sep 27, 2022
Grant date	Sep 27, 2022

Abstract

The invention relates to compositions of co-polymers having hydrophilic and biodegradable hydrophobic units or blocks, resulting in improved properties and functionalities suitable for biomedical applications as self-fitting tissue scaffolds or minimally invasive surgical implants.

First claim

The invention claimed is:

1. A biodegradable composite scaffold comprising an amphiphilic and biodegradable thermoplastic co-polymer comprising blocks of poly(ethylene glycol) and blocks of poly(lactic-co-glycolic acid) forming a 2-D or 3-D scaffold, wherein the molar ratio of lactic acid to glycolic acid is about 19 to about 0.8.

2. The biodegradable composite scaffold of claim 1 , wherein the thermoplastic co-polymer forms a 3-D scaffold.

3. The biodegradable composite scaffold of claim 2 , further comprising one or more inorganic minerals attached to or encapsulated in the 3-D scaffold.

4. The biodegradable composite scaffold of claim 3 , wherein the molar ratio of lactic acid to glycolic acid is about 10 to about 0.8.

5. The biodegradable composite scaffold of claim 4 , wherein the molar ratio of ethylene glycol to (lactic acid+glycolic acid) is about 0.18 to about 0.89.

6. The biodegradable composite scaffold of claim 5 , wherein the amphiphilic and biodegradable thermoplastic co-polymer is characterized by a molecular weight M w from about 70,000 to about 140,000 with the molecular weight of blocks of poly(ethylene glycol) ranging from about 15,000 to about 25,000 and the molecular weight M w of blocks of poly(lactic-co-glycolic acid) ranging from about 45,000 to about 125,000.

7. The biodegradable composite scaffold of claim 6 , characterized by an enhanced mechanical strength upon hydration.

8. The biodegradable composite scaffold of claim 7 , wherein the mechanical strength upon hydration is enhanced by microphase separation and/or crystallization.

9. The biodegradable composite scaffold of claim 8 , wherein the one or more inorganic minerals are selected from the group consisting of calcium apatites, calcium phosphates, hydroxyapatite, and substituted hydroxyapatites.

10. The biodegradable composite scaffold of claim 8 , having a shape of a mesh, sheet, wire, rod, plate, cylinder or a shape matching with that of a tissue defect.

11. The biodegradable composite scaffold of claim 10 , having a longest dimension in the range from about 1 mm to about 20 cm and a shortest dimension in the range from about 0.2 mm to about 5 cm.

12. The biodegradable composite scaffold of claim 8 , further comprising a bioactive material selected from the group consisting of cells, growth factors, cytokines, gene vectors, antibiotics, drugs, and bacterial phage.

13. The biodegradable composite scaffold of claim 12 , wherein the molar ratio of lactic acid to glycolic acid is about 19 to about 0.8 and the molar ratio of ethylene glycol to (lactic acid+glycolic acid) is about 0.18 to about 0.90.

Assignees

• Univ Massachusetts

Inventors

• Song Jie
• Zhang Ben

Classifications

• C08G63/664 Primary

  derived from hydroxy carboxylic acids · CPC title

• A61L27/18

  obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds · CPC title

• C08K3/32

  Phosphorus-containing compounds · CPC title

• A61L27/58

  Materials at least partially resorbable by the body · CPC title