Method and device for displaying predicted volume of influence

Patent metadata

Field	Value
Publication number	US-11452871-B2
Application number	US-201916396337-A
Country	US
Kind code	B2
Filing date	Apr 26, 2019
Priority date	Jul 7, 2004
Publication date	Sep 27, 2022
Grant date	Sep 27, 2022

Abstract

This document discusses, among other things, brain stimulation models, systems, devices, and methods, such as for deep brain stimulation (DBS) or other electrical stimulation. In an example, volumetric imaging data representing an anatomical volume of a brain of a patient can be obtained and transformed to brain atlas data. A patient-specific brain atlas can be created using the inverse of the transformation to map the brain atlas data onto the volumetric imaging data and a volume of influence can be calculated using the patient-specific brain atlas. In certain examples, the volume of influence can include a predicted volume of tissue affected by an electrical stimulation delivered by an electrode at a corresponding at least one candidate electrode target location.

First claim

What is claimed as new and desired to be protected by Letters Patent of the United States is:

1. A method for determining parameter settings for electrical stimulation, the method comprising:
obtaining, by a computer processor, at least one first region in which neuronal activation is desired and at least one second region in which neuronal activation should be avoided;
for each of a plurality of test electrode locations or test electrode parameters of a stimulation leadwire:
determining, by the computer processor, a volume of activation (VOA) based on a neuron model and an electrical potential distribution using the test electrode location or test electrode parameter; and
comparing, by the computer processor, the VOA to both the at least one first region and the at least one second region;

selecting a target electrode location or a target electrode parameter from among the test electrode locations or test electrode parameters using the comparisons between the VOAs and both the at least one first region and the at least one second region; and
communicating the selected target electrode location or target electrode parameter to an implanted controller circuit for production of electrical stimulation of patient tissue using an implanted leadwire coupled to the controller circuit at the selected target electrode location or using the selected target electrode parameter.

2. The method of claim 1 , wherein the selecting includes selecting the target electrode location.

3. The method of claim 1 , wherein the selecting includes selecting the target electrode parameter.

4. The method of claim 3 , wherein the target electrode parameter includes at least one of a stimulation amplitude, a stimulation pulsewidth, a stimulation frequency, an electrode contact, an electrode polarity, or an electrode pulse polarity.

5. The method of claim 1 , wherein the comparing comprises generating a score for the VOA based on overlap between the VOA and the at least one first region and on overlap between the VOA and the at least one second region.

6. The method of claim 5 , wherein generating the score comprises generating a first score by counting how many voxels of the VOA are in the at least one first region and generating a second score by counting how may voxels of the VOA are in the at least one second region.

7. The method of claim 6 , wherein generating the score comprises generating the score by subtracting the second score from the first score.

8. The method of claim 6 , wherein generating the score comprises weighting the first score by a first weight to produce a first weighted score, weighting the second score by a second weight to produce a second weighted score, and generating the score by subtracting the second weighted score from the first weighted score, wherein the second weight is different from the first weight.

9. The method of claim 1 , wherein determining the volume of activation (VOA) comprises determining the VOA using a second difference of the electrical potential distribution.

10. The method of claim 1 , wherein the at least one first region is at least one specified first anatomic region.

11. The method of claim 1 , wherein the at least one second region is at least one specified second anatomic region.

12. A system comprising:
a processor; and
a non-transitory computer-readable medium on which are stored instructions that are executable by the processor, the instructions which, when executed by the processor, cause the processor to:
obtaining at least one first region in which neuronal activation is desired and at least one second region in which neuronal activation should be avoided;
for each of a plurality of test electrode locations or test electrode parameters of a stimulation leadwire:
determining a volume of activation (VOA) based on a neuron model and an electrical potential distribution using the test electrode location or test electrode parameter; and
comparing the VOA to both the at least one first region and the at least one second region;

selecting a target electrode location or a target electrode parameter from among the test electrode locations or test electrode parameters using the comparisons between the VOAs and both the at least one first region and the at least one second region; and
communicating the selected target electrode location or target electrode parameter to an implanted controller circuit for production of electrical stimulation of patient tissue using an implanted leadwire coupled to the controller circuit at the selected target electrode location or using the selected target electrode parameter.

13. The system of claim 12 , wherein the selecting includes selecting the target electrode location.

14. The system of claim 12 , wherein the selecting includes selecting the target electrode parameter.

15. The system of claim 14 , wherein the target electrode parameter includes at least one of a stimulation amplitude, a stimulation pulsewidth, a stimulation frequency, an electrode contact, an electrode polarity, or an electrode pulse polarity.

16. The system of claim 12 , wherein the comparing comprises generating a score for the VOA based on overlap between the VOA and the at least one first region and on overlap between the VOA and the at least one second region.

17. The system of claim 16 , wherein generating the score comprises generating a first score by counting how many voxels of the VOA are in the at least one first region and generating a second score by counting how may voxels of the VOA are in the at least one second region.

18. The system of claim 17 , wherein generating the score comprises generating the score by subtracting the second score from the first score.

19. The system of claim 17 , wherein generating the score comprises weighting the first score by a first weight to produce a first weighted score, weighting the second score by a second weight to produce a second weighted score, and generating the score by subtracting the second weighted score from the first weighted score, wherein the second weight is different from the first weight.

20. The system of claim 12 , wherein determining the volume of activation (VOA) comprises determining the VOA using a second difference of the electrical potential distribution.

Assignees

• Cleveland Clinic Found

Inventors

• Mcintyre Cameron C
• Butson Christopher R
• Hall John D
• Henderson Jaimie M

Classifications

• A61N1/36146

  specified by the stimulation parameters · CPC title

• A61N1/36082 Primary

  Cognitive or psychiatric applications, e.g. dementia or Alzheimer's disease · CPC title

• G16H50/50

  for simulation or modelling of medical disorders · CPC title

• A61N1/36135

  using physiological parameters · CPC title

• A61N1/0534

  Electrodes for deep brain stimulation · CPC title