Hydroxyapatite janus particles

Patent metadata

Field	Value
Publication number	US-11440927-B2
Application number	US-201715823838-A
Country	US
Kind code	B2
Filing date	Nov 28, 2017
Priority date	Nov 28, 2017
Publication date	Sep 13, 2022
Grant date	Sep 13, 2022

Abstract

A hydroxyapatite particle having a plurality of functionalities on a surface, a process for forming a hydroxyapatite particle having a plurality of functionalities on a surface, and an article of manufacture including a hydroxyapatite particle having a plurality of functionalities on a surface are disclosed. The hydroxyapatite particle includes a first functionality on a first surface of the hydroxyapatite particle, where the first functionality includes first moieties to bind to polymer constructs, and a second functionality on a second surface of the hydroxyapatite particle. The process for forming the hydroxyapatite particle includes providing one or more hydroxyapatite particles, forming one or more wax particles, functionalizing a first exposed surface of the one or more hydroxyapatite particles, removing the one or more hydroxyapatite particles from the wax core, and functionalizing the second exposed surface of the one or more hydroxyapatite particles.

First claim

What is claimed is:

1. A hydroxyapatite particle incorporated into a biodegradable polymer construct, the hydroxyapatite particle having a plurality of functionalities on a surface of the hydroxyapatite particle, the hydroxyapatite particle comprising at least:
a first functionality concentrated on a first surface of the hydroxyapatite particle, wherein the first functionality includes first moieties to bind to biodegradable polymer constructs, and wherein the first surface is bound to the biodegradable polymer construct through the first functionality; and
a second functionality concentrated on a second surface of the hydroxyapatite particle, the second surface separate from the first surface, wherein the second functionality includes second moieties.

2. The hydroxyapatite particle of claim 1 , wherein the first moieties to bind to the polymer constructs are selected from a group consisting of azide groups and alkyne groups.

3. The hydroxyapatite particle of claim 2 , wherein the first moieties are azide groups and the polymer constructs are alkyne-functionalized polymer constructs.

4. The hydroxyapatite particle of claim 2 , wherein the first moieties are alkyne groups and the polymer constructs are azide-functionalized polymer constructs.

5. The hydroxyapatite particle of claim 1 , wherein the polymer constructs comprise at least one of polylactic acid, polycaprolactone, polyglycolic acid, and poly(lactic-co-glycolic) acid.

6. The hydroxyapatite particle of claim 1 , wherein the second moieties are bioactive molecules.

7. The hydroxyapatite particle of claim 6 , wherein the bioactive molecules are selected from a group consisting of growth factors, growth factor binding domains derived from proteins, protein domains, peptide sequences, proteins, antibodies, antibodies, cytokines, drugs, deoxyribonucleic acid (DNA), and ribonucleic acid (RNA).

8. An article of manufacture comprising a hydroxyapatite particle incorporated into a biodegradable polymer construct, the hydroxyapatite particle having a plurality of functionalities on a surface of the hydroxyapatite particle, the hydroxyapatite particle comprising at least:
a first functionality concentrated on a first surface of the hydroxyapatite particle, wherein the first functionality includes first moieties to bind to biodegradable polymer constructs, and wherein the first surface is bound to the biodegradable polymer construct through the first functionality; and
a second functionality concentrated on a second surface of the hydroxyapatite particle, the second surface separate from the first surface, wherein the second functionality includes second moieties.

9. The article of manufacture of claim 8 , wherein the first moieties to bind to the polymer constructs include at least one of azide groups and alkyne groups.

10. The article of manufacture of claim 8 , wherein the polymer constructs comprise at least one of polylactic acid, polycaprolactone, polyglycolic acid, and poly(lactic-co-glycolic) acid.

Assignees

• IBM

Inventors

• Czaplewski-Campbell Sarah
• Wertz Jason T
• Kobilka Brandon M
• Campbell Eric

Classifications

• C07F9/06 Primary

  without P—C bonds · CPC title

• C01B25/327 Primary

  After-treatment · CPC title

• A61L2430/02

  for reconstruction of bones; weight-bearing implants · CPC title