Nicotine salts, co-crystals, and salt co-crystal complexes
US-10508096-B2 · Dec 17, 2019 · US
Crystalline forms of dasatinib
US11440908B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-11440908-B2 |
| Application number | US-202016949260-A |
| Country | US |
| Kind code | B2 |
| Filing date | Oct 22, 2020 |
| Priority date | Apr 25, 2018 |
| Publication date | Sep 13, 2022 |
| Grant date | Sep 13, 2022 |
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- Title
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- Abstract
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Abstract
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The present disclosure relates to a dasatinib co-crystal form comprising dasatinib and a second compound, also referred to as a co-crystal former, wherein the second compound is selected from butyl paraben, propyl paraben and ethyl vanillin. The present disclosure is also related to an ethyl formate solvate form of dasatinib. The present disclosure is also related to processes for the preparation of the dasatinib co-crystal and solvate forms of dasatinib. Further, the present disclosure also relates to pharmaceutical compositions comprising the dasatinib co-crystal and solvate forms of dasatinib and methods for treating disease using the dasatinib co-crystal and solvate forms of dasatinib.
First claim
Opening claim text (preview).
What is claimed is: 1. A dasatinib co-crystal comprising dasatinib and a second compound, wherein the second compound is ethyl vanillin, characterized by having at least 2 or more X-ray powder diffraction peaks selected from about 5.7, 10.9, 13.5, 17.1, 18.4, 19.4, 23.7 and 26.3° 2θ. 2. The dasatinib co-crystal according to claim 1 , wherein a molar ratio of the dasatinib to the ethyl vanillin is about 1:1. 3. The dasatinib co-crystal according to claim 1 , which is Form II co-crystal of dasatinib and ethyl vanillin. 4. The dasatinib co-crystal according to claim 3 , characterized by one or more thermal events selected from about 140° C., about 181° C., and about 293° C., as measured by differential scanning calorimetry. 5. The dasatinib co-crystal of claim 3 which is monoclinic, P2 l /n. 6. The dasatinib co-crystal d of claim 3 which has single crystal parameters a=18.452 (1) Å b=9.441 (6) Å c=19.377 (1) Å α=γ=90°, η=108.78 (1°). 7. The dasatinib co-crystal of claim 3 which has a cell volume of about 3195.71 Å 3 .
Assignees
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Classifications
Crystalline forms, e.g. polymorphs · CPC title
- C07D417/12Primary
linked by a chain containing hetero atoms as chain links · CPC title
specific for leukemia · CPC title
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- What does patent US11440908B2 cover?
- The present disclosure relates to a dasatinib co-crystal form comprising dasatinib and a second compound, also referred to as a co-crystal former, wherein the second compound is selected from butyl paraben, propyl paraben and ethyl vanillin. The present disclosure is also related to an ethyl formate solvate form of dasatinib. The present disclosure is also related to processes for the preparati…
- Who is the assignee on this patent?
- Johnson Matthey Plc
- What technology area does this patent fall under?
- Primary CPC classification C07D417/12. Mapped technology areas include Chemistry & Metallurgy.
- When was this patent published?
- Publication date Tue Sep 13 2022 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 6 related publications on this page (citations in our corpus or others sharing the same primary CPC).