Medical devices

Patent metadata

Field	Value
Publication number	US-11439494-B2
Application number	US-201815977967-A
Country	US
Kind code	B2
Filing date	May 11, 2018
Priority date	May 12, 2017
Publication date	Sep 13, 2022
Grant date	Sep 13, 2022

Abstract

Described are medical devices including expandable tubular bodies configured to be implanted into a lumen, wherein the outer surface of the expandable tubular bodies are coupled to a polymer(s).

First claim

We claim:

1. A method of coating an implantable medical device, the method comprising:
activating a surface of the implantable medical device by silanization with a silane, wherein the silane includes a reactive group selected from an acrylate, methacrylate, aldehyde, epoxy, ester, or a combination thereof, and
coupling a polymer formed from a first acrylate monomer and a second monomer containing an amine, a carboxylic acid, or a hydroxyl group to the reactive group of the activated surface, wherein the first monomer is alkoxyalkyl (meth)acrylate, tetrahydrofurfuryl acrylate, or

wherein
R 1 is hydrogen,
R 2 is an alkylene group with 1 to 4 carbons, and
R 3 is an alkyl group with 1 to 4 carbons.

2. The method of claim 1 further comprising hydroxylation of the surface using oxygen plasma.

3. The method of claim 2 , wherein the oxygen plasma is applied by an oxygen flow of about 120 sccm, a power of about 500 watts, a pressure of about 400 mTorr, a time of about 5 minutes, or a combination thereof.

4. The method of claim 1 , wherein silanization occurs through reaction with a silane selected from:

or a combination thereof.

5. The method of claim 4 , wherein n is 8-12.

6. The method of claim 1 further comprising argon plasma treatment after silanization.

7. The method of claim 6 , wherein the argon plasma is applied by an argon flow of about 365 sccm, a power of about 300 watts, a pressure of about 500 mTorr, a time of about 10 minutes, or a combination thereof.

8. The method of claim 1 , wherein the coupling is by dip coating, spraying, brushing, or a combination thereof.

9. The method of claim 1 , wherein the first monomer is tetrahydrofurfuryl acrylate.

10. The method of claim 1 , wherein the second monomer is acrylic acid, methacrylic acid, hydroxyethyl methacrylate, hydroxyethyl acrylate, hydroxypropyl acrylate, hydroxybutyl acrylate, aminoethyl methacrylate, aminopropyl methacrylamide, a combination thereof.

11. The method of claim 1 , wherein the silane includes an epoxy reactive group.

12. The method of claim 1 , wherein the first monomer is alkoxyalkyl (meth)acrylate.

13. The method of claim 1 , wherein silanization occurs through reaction with a silane selected from:

or a combination thereof.

14. The method of claim 1 , wherein the second monomer is hydroxybutyl acrylate, aminopropyl methacrylamide, or a combination thereof.

15. The method of claim 1 , wherein the first monomer is methoxyethyl acrylate.

Assignees

• Microvention Inc

Inventors

• Wu Xinping
• Hong Jodi
• Cruise Gregory M

Classifications

• A61L31/022 Primary

  Metals or alloys · CPC title

• A61L31/08

  Materials for coatings · CPC title

• A61L2400/18

  Modification of implant surfaces in order to improve biocompatibility, cell growth, fixation of biomolecules, e.g. plasma treatment · CPC title

• A61F2/06 Primary

  Blood vessels · CPC title

• A61L31/10

  Macromolecular materials · CPC title