Devices and methods for endoscopic patch delivery

Patent metadata

Field	Value
Publication number	US-11439374-B2
Application number	US-201916525888-A
Country	US
Kind code	B2
Filing date	Jul 30, 2019
Priority date	Jul 31, 2018
Publication date	Sep 13, 2022
Grant date	Sep 13, 2022

Abstract

Systems and methods of delivering a patch to a target site of a patient are described herein. The patch may comprise a biomaterial such as chitosan or extracellular matrix and may be biocompatible and/or bioresorbable. The system may include an endoscope, a patch, and one of an instrument or a cap, the patch being coupled to the respective instrument or cap and detachable therefrom. Methods of delivering the patch to the target site may include introducing an endoscope into a gastrointestinal tract of a patient, e.g., the patch being in a folded or crimped configuration, navigating a distal end of the endoscope proximate a target site; and applying the patch to the target site while releasing the patch from the endoscope.

First claim

We claim:

1. A method of delivering a patch to a target site of a patient, the method comprising:
introducing an endoscope into a gastrointestinal tract of a patient, wherein the endoscope includes a patch in a folded or crimped configuration, the patch comprising a biocompatible material;
positioning a distal end of the endoscope proximate a target site; and
applying the patch to the target site while releasing the patch from the endoscope;
wherein the target site includes a laceration in tissue following endoscopic mucosal resection (EMR), endoscopic submucosal dissection (ESD), or tissue biopsy; or wherein the target site includes an anastomosis;
wherein the endoscope includes a cap coupled to the distal end of the endoscope, the patch covering a distal end of the cap and being releasable from the cap;
wherein the patch is secured to an outer surface of the cap with a flexible band; and
wherein releasing the patch from the cap includes actuating a wire to cut the flexible band from the cap.

2. The method of claim 1 , wherein the patch comprises chitosan, extracellular matrix, or a combination thereof.

3. The method of claim 1 , wherein the cap has a frustoconical shape and a ridge on an outer surface of the cap.

4. The method of claim 1 , wherein the distal end of the endoscope includes an optical device, and the patch includes an opening aligned with the optical device.

5. The method of claim 1 , wherein the cap is fixedly coupled to the distal end of the endoscope.

6. The method of claim 1 , wherein releasing the patch from the cap includes applying pressure to the patch with the endoscope.

7. A method of delivering a patch to a target site of a patient, the method comprising:
introducing a system comprising an endoscope into a gastrointestinal tract of a patient, wherein the system includes a patch comprising a biocompatible material and
a cap fixedly coupled to a distal end of the endoscope, wherein the patch is secured to an outer surface of the cap with a flexible band, covers a distal opening of the cap, and is releasable from the cap;

positioning a distal end of the endoscope proximate a target site; and
applying the patch to the target site while releasing the patch from cap;
wherein releasing the patch from the cap includes actuating a wire to release the flexible band.

8. The method of claim 7 , wherein applying the patch includes blowing air or spraying water from a channel of the endoscope onto the patch.

9. The method of claim 7 , wherein releasing the patch from the cap includes actuating the wire to cut the flexible band, and a portion of the flexible band remains tethered to the cap after the flexible band is cut.

10. A medical system comprising:
an endoscope defining at least one working channel;
a patch comprising a biocompatible material; and
a cap coupled to a distal end of the endoscope, the patch covering a distal end of the cap and being releasable from the cap;
wherein the patch is secured to an outer surface of the cap with a flexible band;
wherein a wire extending through the at least one working channel is coupled to the flexible band;
wherein the distal end of the endoscope includes an optical device, and the patch includes an opening aligned with the optical device.

Assignees

• Boston Scient Scimed Inc

Inventors

• Smith Amanda
• Pic Andrew
• Rebar Hannah

Classifications

• A61F2/0063

  Implantable repair or support meshes, e.g. hernia meshes · CPC title

• A61F2002/045

  Stomach, intestines · CPC title

• A61F2002/044

  Oesophagi or esophagi or gullets · CPC title

• A61F2/04

  Hollow or tubular parts of organs, e.g. bladders, tracheae, bronchi or bile ducts (A61F2/18, A61F2/20 take precedence; instruments specially adapted for placement or removal of stents or stent-grafts A61F2/95) · CPC title

• A61F2002/0072

  Delivery tools therefor · CPC title