Supercritical fluid apparatus

Patent metadata

Field	Value
Publication number	US-11435324-B2
Application number	US-201716643795-A
Country	US
Kind code	B2
Filing date	Sep 15, 2017
Priority date	Sep 15, 2017
Publication date	Sep 6, 2022
Grant date	Sep 6, 2022

Abstract

Provided is a supercritical fluid apparatus including: an analysis flow path through which a mobile phase flows; a back-pressure control valve provided at a downstream end of the analysis flow path to adjust pressure in the analysis flow path to a predetermined pressure; a small-diameter pipe connected to the outlet of the back-pressure control valve, having an inner diameter allowing internal pressure to be maintained at a pressure higher than the atmospheric pressure; a large-diameter pipe connected to a downstream end of the small-diameter pipe, having a larger inner diameter than the small-diameter pipe; and a large-diameter pipe heating part for heating the large-diameter pipe.

First claim

The invention claimed is:

1. A supercritical fluid apparatus comprising:
an analysis flow path through which a mobile phase flows;
a back-pressure control valve provided at a downstream end of the analysis flow path to regulate pressure in the analysis flow path to a predetermined pressure;
a small-diameter pipe connected to the outlet of the back-pressure control valve, and having an inner diameter designed so that internal pressure of the small-diameter pipe is maintained at a pressure higher than the atmospheric pressure;
a large-diameter pipe connected to a downstream end of the small-diameter pipe, having an inner diameter larger than that of the small-diameter pipe;
a coupling provided between the small-diameter pipe and the large-diameter pipe to connect the small-diameter pipe and the large-diameter pipe;
a large-diameter pipe heating part arranged only on the large-diameter pipe; and
a small-diameter pipe heating part arranged only on the small-diameter pipe and configured to heat the small-diameter pipe with a heating amount smaller than that of the larger-diameter heating part.

2. The supercritical fluid apparatus according to claim 1 , wherein the large-diameter pipe heating part includes an electric circuit configured to cause an electric current to flow through the large-diameter pipe to cause the large-diameter pipe to generate heat.

3. The supercritical fluid apparatus according to claim 1 , wherein the inner diameter of the small-diameter pipe is substantially identical to an inner diameter of an outlet flow path provided in the back-pressure control valve.

4. The supercritical fluid apparatus according to claim 1 , wherein the inner diameter of the large-diameter pipe is at least twice the inner diameter of the small-diameter pipe.

5. A supercritical fluid apparatus comprising:
an analysis flow path through which a mobile phase flows;
a back-pressure control valve provided at a downstream end of the analysis flow path to regulate pressure in the analysis flow path to a predetermined pressure;
a small-diameter pipe connected to the outlet of the back-pressure control valve, and having an inner diameter designed so that internal pressure of the small-diameter pipe is maintained at a pressure higher than the atmospheric pressure;
a large-diameter pipe connected to a downstream end of the small-diameter pipe, having an inner diameter larger than that of the small-diameter pipe;
a large-diameter pipe heating part for heating the large-diameter pipe;
a small-diameter pipe heating part configured to heat the small-diameter pipe with a heating amount smaller than that of the large-diameter pipe heating part; and
a controller configured to control each heating amount of the large-diameter pipe heating part and the small-diameter pipe heating part,
wherein the controller is configured to cause the small-diameter pipe heating part to heat the small-diameter pipe when a mobile phase flowing through the analysis flow path has a flow rate equal to or lower than a predetermined flow rate, and is configured to cause only the large-diameter pipe heating part to heat the large-diameter pipe when the mobile phase flowing through the analysis flow path has a flow rate more than the predetermined flow rate.

6. A supercritical fluid apparatus comprising:
an analysis flow path through which a mobile phase flows;
a back-pressure control valve provided at a downstream end of the analysis flow path to regulate pressure in the analysis flow path to a predetermined pressure;
a small-diameter pipe connected to the outlet of the back-pressure control valve, and having an inner diameter designed so that internal pressure of the small-diameter pipe is maintained at a pressure higher than the atmospheric pressure;
a large-diameter pipe connected to a downstream end of the small-diameter pipe, having an inner diameter larger than that of the small-diameter pipe;
a large-diameter pipe heating part for heating the large-diameter pipe;
a small-diameter pipe heating part configured to heat the small-diameter pipe with a heating amount smaller than that of the large-diameter pipe heating part;
a temperature sensor detecting temperature of the large-diameter pipe heating part; and
a controller configured to control each heating amount of the large-diameter pipe heating part and the small-diameter pipe heating part,
wherein the controller is configured to cause only the small-diameter pipe heating part to be driven when temperature of the large-diameter pipe detected by the temperature sensor is equal to or higher than a predetermined temperature, and is configured to cause the large-diameter pipe heating part to be driven when the temperature of the large-diameter pipe is lower than the predetermined temperature.

Assignees

• Shimadzu Corp

Inventors

• KORA Chihiro

Classifications

• B01D15/161

  Temperature conditioning · CPC title

• G01N2030/326

  pumps · CPC title

• G01N2030/027

  Liquid chromatography · CPC title

• B01D15/40 Primary

  using supercritical fluid as mobile phase or eluent · CPC title

• G01N2030/328

  valves, e.g. check valves of pumps · CPC title