Stuck slide determination system

Patent metadata

Field	Value
Publication number	US-11434082-B2
Application number	US-202016877289-A
Country	US
Kind code	B2
Filing date	May 18, 2020
Priority date	Oct 4, 2017
Publication date	Sep 6, 2022
Grant date	Sep 6, 2022

Abstract

A stuck slide determination system is provided that determines if a slide (e.g., glass slide), positioned on a scanning stage at the start of the scanning process, gets stuck and does not move along with the scanning stage after the scanning process commences. In an embodiment, the system includes a sensor having a transmitter and receiver that are relatively positioned to detect the presence of the stage or a slide or the absence of the stage or a slide. When the scanning stage begins to move at the start of the scanning process, a processor monitors a signal from the sensor and determines if the slide is improperly positioned after the scanning process has commenced. If the slide is improperly positioned, the processor stops movement of the scanning stage in order to protect the slide from damage.

First claim

What is claimed is:

1. A digital slide scanning apparatus comprising:
a scanning stage configured to receive and secure a slide;
transmitter and a receiver positioned above and offset from the scanning stage to detect the presence or absence of a slide at one or more positions during a scanning process, the transmitter configured to transmit a signal that reflects from a surface at the one or more positions and is received by the receiver; and
at least one processor configured to, during the scanning process for a slide,
control movement of a motor to move the scanning stage,
receive and analyze the signal resulting from the reflection to determine a presence or absence of the slide, and
based on this determination, control movement of the scanning stage.

2. The digital slide scanning apparatus of claim 1 , wherein the at least one processor is configured to determine that the slide is improperly positioned based on the presence of the slide at a position external to the scanning stage.

3. The digital slide scanning apparatus of claim 1 , wherein the at least one processor is configured to determine that the slide is improperly positioned based on the absence of the slide at a position on the scanning stage.

4. The digital slide scanning apparatus of claim 1 , wherein the at least one processor is configured to determine that the slide is present when the receiver receives the signal transmitted by the transmitter.

5. The digital slide scanning apparatus of claim 1 , wherein the at least one processor is configured to determine that the slide is absent when the receiver does not receive the signal transmitted by the transmitter.

6. The digital slide scanning apparatus of claim 1 , wherein the scanning stage comprises a through-hole, over which a glass slide is supported by the scanning stage and through which a glass slide can be illuminated while on the scanning stage during the scanning process, and wherein the transmitter is positioned such that, when a glass slide is improperly positioned during movement of the scanning stage, the signal transmitted by the transmitter passes through the through hole without reflecting to the receiver.

7. The digital slide scanning apparatus of claim 1 , wherein the at least one processor is configured to, prior to loading a first slide onto the scanning stage:
receive the signal from the transmitter,
analyze the signal to determine a presence of a second slide on the scanning stage, and
prevent loading of the first slide onto the scanning stage as long as the second slide is determined to be present on the scanning stage.

8. The digital slide scanning apparatus of claim 7 , further comprising:
a slide rack configured to hold slides in slots; and
an assembly configured to load and unload slides from the slide rack onto and from the scanning stage,
wherein the at least one processor is configured to,
control the assembly to unload the second slide into a slot in the slide rack prior to loading the first slide, and
control the assembly to load the first slide from a slot in the slide rack onto the scanning stage after unloading the second slide.

9. The digital slide scanning apparatus of claim 1 , wherein the at least one processor is configured to, prior to commencing the scanning process:
receive the signal from the transmitter,
analyze the signal to determine a presence or absence of a slide on the scanning stage, and
prevent commencement of the scanning process until after determining that a slide is present on the scanning stage.

10. The digital slide scanning apparatus of claim 1 , further comprising:
a slide rack comprising a plurality of slots configured to hold slides; and
an assembly configured to load a slide from each of the plurality of slots in the slide rack onto the scanning stage, and unload a slide from the scanning stage into each of the plurality of slots in the slide rack,
wherein the at least one processor is configured to control the assembly to load a slide from each of the plurality of slots in the slide rack onto the scanning stage, and
unload a slide from the scanning stage into each of the plurality of slots in the slide rack.

11. The digital slide scanning apparatus of claim 10 , wherein the at least one processor is configured to, when the slide is determined to be improperly positioned, control the assembly to:
at least partially unload the slide into a slot in the slide rack; and
reload the slide from the slot in the slide rack onto the scanning stage.

12. The digital slide scanning apparatus of claim 1 , wherein the at least one processor is configured to, when the slide is determined to be improperly positioned, cause repositioning of the scanning stage.

13. A digital slide scanning apparatus comprising:
a scanning stage configured to receive and secure a slide;
a motor configured to engage with and move the scanning stage;
a sensor pair comprising a transmitter and a receiver positioned to detect the presence or absence of a slide at one or more positions during a scanning process; and
at least one processor configured to:
control the motor,
receive a signal from the sensor pair,
analyze the signal to determine a presence of the slide at a sensing position,
determine whether the slide is improperly positioned by detecting the presence or absence of the slide at the sensing position, wherein the sensing position is within a boundary of the slide if the slide is properly positioned on the scanning stage prior to commencement of the scanning process, and is outside the boundary of the slide if the slide remains properly positioned on the scanning stage during at least a beginning portion of the scanning process, and,
when the slide is determined to be improperly positioned, control the motor to stop movement of the scanning stage.

14. The digital slide scanning apparatus of claim 13 , wherein both of the transmitter and the receiver are positioned on a same side of the scanning stage.

15. The digital slide scanning apparatus of claim 14 , wherein the transmitter and the receiver of the sensor pair are positioned above the scanning stage,
wherein the transmitter is configured to transmit the signal, and
wherein the receiver is configured to receive the signal, transmitted by the transmitter, when the signal is reflected by a surface at the one or more positions.

16. The digital slide scanning apparatus of claim 13 , wherein the transmitter of the sensor pair is positioned on a different side of the scanning stage than the receiver of the sensor pair.

17. A digital slide scanning apparatus comprising:
a scanning stage configured to receive and secure a slide;
a motor configured to move the scanning stage;
a transmitter positioned on one side of the scanning stage;
a receiver positioned on the other side of the scanning stage;
the transmitter and receiver positioned to detect the presence or absence of a slide at one or more positions;
one of the transmitter and receiver is positioned above and the other is positioned below the scanning stage;
the transmitter is configured to transmit a signal, and the receiver positioned in a line of sight of the transmitter such that it can receive the transmitted signal when the signal passes through the one or more positions; and
at least one processor configured to:
control the motor to move the scanning stage,
receive the signal from one or more of the transmitter and receiver,
analyze the signal to determine a presence or absence of the slide,
determine that the slide is improperly positioned based on the

Assignees

• Leica Biosystems Imaging Inc

Inventors

• Newberg Nicholas
• Djelosevic Prentash
• Stearrett Aaron
• Najmabadi Peyman

Classifications

• G02B21/0076

  arrangements using fluorescence or luminescence · CPC title

• G02B21/34 Primary

  Microscope slides, e.g. mounting specimens on microscope slides · CPC title

• G01V8/12

  using one transmitter and one receiver · CPC title

• G02B21/00

  Microscopes · CPC title

• G01N2035/00138

  Slides · CPC title