Method for making silicone hydrogel contact lenses

Patent metadata

Field	Value
Publication number	US-11433630-B2
Application number	US-201916709119-A
Country	US
Kind code	B2
Filing date	Dec 10, 2019
Priority date	Dec 14, 2018
Publication date	Sep 6, 2022
Grant date	Sep 6, 2022

Abstract

The present invention generally relates to a method for producing silicone hydrogel contact lenses having less optical defects or free of optical defects by subjecting the extraction tray for the formed silicone hydrogel contact lenses to a reciprocating lowering and raising motion thereof to obtain the silicone hydrogel contact lenses.

First claim

What is claimed is:

1. A method for producing silicone hydrogel contact lenses with significantly reduced optical defect comprising the steps of:
(1) introducing a polymerizable lens-forming material into a lens mold, wherein the lens-forming material is a silicone hydrogel lens-forming material,
(2) curing thermally or actinically the polymerizable lens-forming material in the lens mold to form a silicone hydrogel contact lens;
(3) extracting the formed silicone hydrogel contact lenses which are hold in extraction trays by at least two extracting stages in a single process tank,
wherein the extracting step comprises the following steps:
a) extracting the formed silicone hydrogel contact lenses with a first extracting medium, wherein the first extracting medium is a first solvent or a mixture of the first solvent and water,
b) draining the first extracting medium out of the process tank,
c) refilling the process tank with a 100% water, wherein during refilling the process tank, subjecting the extraction tray for the formed silicone hydrogel contact lenses to a reciprocating lowering and raising motion thereof to obtain the silicone hydrogel contact lenses,

wherein the silicone hydrogel contact lenses have reduced tray marks and/or dimples observed using a contact lens optical quality analyzer, relative to control silicone hydrogel contact lenses obtained by the same processes except for eliminating the reciprocating lowering and raising motion in step c).

2. The method of claim 1 , wherein the silicone hydrogel lens-forming material comprises (a) at least silicone-containing polymerizable component which is at least one siloxane-containing vinylic monomer, at least one silicone-containing vinylic macromer, or a combination thereof, (b) at least one vinylic crosslinking agent, (c) a blending vinylic monomer selected from the group consisting of a C1-C10 alkyl methacrylate, isobornylmethacrylate, isobornylacrylate, cyclopentylmethacrylate, cyclopentylacrylate, cyclohexylmethacrylate, cyclohexylacrylate, styrene, 2,4,6-trimethylstyrene (TMS), and t-butyl styrene (TBS), (d) from about 30% to about 60% by weight of at least one N-vinyl amide monomer relative to the total amount of polymerizable components, and (e) at least one initiator.

3. The method of claim 1 , wherein the silicone hydrogel lens-forming material comprises from about 35% to about 56% by weight of N-vinylpyrrolidone relative to the total amount of polymerizable components, wherein the polymerizable composition is a solution of all desirable components dissolved in propylene glycol or a polyethylene glycol having a molecular weight of about 400 Daltons or less.

4. The method of claim 1 , wherein the blending vinylic monomer is a C 1 -C 10 alkyl (meth)acrylate, cyclopentylacrylate, cyclohexylmethacrylate, cyclohexylacrylate, isobornyl (meth)acrylate, styrene, 4,6-trimethylstyrene (TMS), t-butyl styrene (TBS), trifluoroethyl (meth)acrylate, hexafluoro-isopropyl (meth)acrylate, hexafluorobutyl (meth)acrylate, or combinations thereof.

5. The method of claim 4 , wherein the step of curing is carried out thermally for a time period of at least about 60 minutes, wherein the polymerizable composition comprises at least one thermal free-radical initiator.

6. The method of claim 4 , wherein the step of curing is carried out by UV/visible irradiation, wherein the polymerizable composition comprises at least one free-radical photoinitiator.

7. The method of claim 2 , wherein the first extracting medium is 1-propanol.

Assignees

• Alcon Inc

Inventors

• Lu Honghui
• Neely Mark
• Liu Alice Weimin
• Niu Xuxian
• Haken Uwe

Classifications

• G02B1/043

  Contact lenses · CPC title

• B29D11/00134

  Curing of the contact lens material · CPC title

• B29D11/00192

  Demoulding, e.g. separating lenses from mould halves · CPC title

• B29D11/0025 Primary

  Removing impurities from contact lenses, e.g. leaching · CPC title

• B29K2083/00

  Use of polymers having silicon, with or without sulfur, nitrogen, oxygen, or carbon only, in the main chain, as moulding material · CPC title