Magnetic assisted separation apparatuses and related methods

Patent metadata

Field	Value
Publication number	US-11433402-B2
Application number	US-201816018923-A
Country	US
Kind code	B2
Filing date	Jun 26, 2018
Priority date	Jul 19, 2017
Publication date	Sep 6, 2022
Grant date	Sep 6, 2022

Abstract

Magnetic assisted separation apparatuses for separating a target substance from a medium in which the target substance is suspended, and related methods, are provided. According to one aspect, a magnetic separator may include a frame having an opening configured to receive one or more containers containing the medium. Additionally, the magnetic separator may include first and second magnetic field generating elements mounted on opposing sides of the frame such that one or more containers can be positioned between the first and second magnetic field generating elements. According to another aspect, a workstation includes a work surface for receiving one or more containers containing the medium, a fluid transfer member, an automated manipulator configured to move the fluid transfer member, and a plurality magnetic field generating elements each being moveable between a position remote from the one or more containers and another position adjacent to the one or more containers.

First claim

What is claimed is:

1. A magnetic separator for separating a target substance from a medium in which the target substance is suspended, the medium being contained in at least one container, the magnetic separator apparatus comprising:
a frame having a first sidewall and a second sidewall, wherein the first sidewall is spaced from the second sidewall to define a first opening configured to receive the at the least one container between the first sidewall and the second sidewall;
a first magnetic field generating element coupled to the first sidewall and a second magnetic field generating element coupled to the second sidewall such that the first magnetic field generating element and the first sidewall are positioned across the first opening from the second magnetic field generating element and the second sidewall and such that the at least one container is positionable between the first and second magnetic field generating elements;
the first magnetic field generating element comprising a first surface facing the first sidewall and a second surface configured to face the at least one container, wherein the first surface and the second surface of the first magnetic field generating element face in opposite directions; and
the second magnetic field generating element comprising a first surface facing the second sidewall and a second surface configured to face the at least one container, wherein the first surface and the second surface of the second magnetic field generating element face in opposite directions,
the first magnetic field generating element being mounted on an inwardly facing surface of the first sidewall, and the second magnetic field generating element being mounted on an inwardly facing surface of the second sidewall, and
at least one of a beam or a third wall extending between the inwardly facing surface of the first sidewall and the inwardly facing surface of the second sidewall.

2. The magnetic separator of claim 1 , the first sidewall being parallel to the second sidewall.

3. The magnetic separator of claim 1 , the first opening being defined between the first and second sidewalls and permitting the at least one container to be inserted in a horizontal direction into the magnetic separator.

4. The magnetic separator of claim 3 , comprising a second opening formed in the frame and permitting access to the at least one container from above when the at least one container is positioned between the first magnetic field generating element and the second magnetic field generating element.

5. The magnetic separator of claim 1 , comprising a non-magnetic support rack configured to hold the at least one container and dimensioned for insertion through the first opening to position the at least one container between the first and second magnetic field generating elements.

6. The magnetic separator of claim 5 , when inserted through the first opening, a first end of the non-magnetic support rack fitting beneath the first magnetic field generating element and a second end of the non-magnetic support rack fitting beneath the second magnetic field generating element.

7. The magnetic separator of claim 5 , the at least one container including a plurality of containers, the non-magnetic support rack being configured prevent lateral movement of the plurality of containers relative to each other.

8. The magnetic separator of claim 1 , the first magnetic field generating element including a first permanent magnet.

9. The magnetic separator of claim 8 , the first permanent magnet having a maximum magnetic pull force equal to or greater than 100 Newtons (N).

10. The magnetic separator of claim 1 , comprising a bottom wall extending between the first sidewall and the second sidewall and having an upwardly facing surface configured to support the at least one container.

11. The magnetic separator of claim 1 , wherein the first magnetic field generating element is configured to be positioned between the first sidewall and the at least one container, and the second magnetic field generating element is configured to be positioned between the second sidewall and the at least one container.

12. The magnetic separator of claim 1 , wherein:
the first sidewall comprises an inwardly facing surface facing the first surface of the first magnetic field generating element;
the second sidewall comprises an inwardly facing surface facing the first surface of the second magnetic field generating element; and
the inwardly facing surface of the first sidewall faces the inwardly facing surface of the second sidewall.

13. A magnetic separator for separating a target substance from a medium in which the target substance is suspended, the medium being contained in at least one container, the magnetic separator apparatus comprising:
a frame having a first sidewall and a second sidewall, wherein the first sidewall is spaced from the second sidewall to define a first opening configured to receive the at the least one container between the first sidewall and the second sidewall;
a first magnetic field generating element coupled to the first sidewall and a second magnetic field generating element coupled to the second sidewall such that the first magnetic field generating element and the first sidewall are positioned across the first opening from the second magnetic field generating element and the second sidewall and such that the at least one container is positionable between the first and second magnetic field generating elements;
the first magnetic field generating element being mounted on an inwardly facing surface of the first sidewall, and the second magnetic field generating element being mounted on an inwardly facing surface of the second sidewall; and
a non-magnetic support rack configured to hold the at least one container and dimensioned for insertion through the first opening to position the at least one container between the first and second magnetic field generating elements.

14. The magnetic separator of claim 13 , when inserted through the first opening, a first end of the non-magnetic support rack fitting beneath the first magnetic field generating element and a second end of the non-magnetic support rack fitting beneath the second magnetic field generating element.

15. The magnetic separator of claim 13 , the at least one container including a plurality of containers, the non-magnetic support rack being configured prevent lateral movement of the plurality of containers relative to each other.

Assignees

• Amgen Inc

Inventors

• Schulz Craig Michael
• Provchy Justin James
• Kawooya John Kasajja

Classifications

• G01N35/1065

  Multiple transfer devices · CPC title

• B01L2200/023

  adapted for different sizes of tubes, tips or container · CPC title

• B03C2201/18

  Magnetic separation whereby the particles are suspended in a liquid · CPC title

• B03C1/288 Primary

  disposed at the outer circumference of a recipient · CPC title

• B01L9/06

  Test-tube stands; Test-tube holders · CPC title