Targeted antimicrobial photodynamic therapy
US-2019314502-A1 · Oct 17, 2019 · US
US11425905B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-11425905-B2 |
| Application number | US-202117244688-A |
| Country | US |
| Kind code | B2 |
| Filing date | Apr 29, 2021 |
| Priority date | Sep 2, 2020 |
| Publication date | Aug 30, 2022 |
| Grant date | Aug 30, 2022 |
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An antimicrobial preventive netting is disclosed that includes one or more photosensitizers that are capable of generating a cloud of singlet oxygen on each surface and openings through the netting in response to incident light. A depth of the singlet oxygen cloud may be less than 0.7 centimeters from a netting surface. The netting may be supported by screens, enclosures or headgear. The netting can be made by dipping or soaking the netting in a solution of one or more photosensitizers.
Opening claim text (preview).
The embodiments of the invention in which an exclusive property or privilege is claimed are defined as follows: 1. A antimicrobial preventive netting, comprising: the netting having a plurality of openings between a top surface and a bottom surface; and photosensitizers that are distributed on the top surface, the bottom surface and through the plurality of openings, wherein the photosensitizers generate a cloud of singlet oxygen on the netting in response to incident light, wherein the photosensitizers include methylene blue, erythrosine, and riboflavin, wherein the amount of methylene blue is less than an amount of erythrosine or an amount of riboflavin, wherein a ratio of methylene blue to erythrosine to riboflavin is 1:2:2. 2. The antimicrobial preventive netting of claim 1 , wherein the cloud of singlet oxygen on the netting, further comprises a maximum depth of less than 0.7 centimeters from the top surface and bottom surface of the netting. 3. The antimicrobial preventive netting of claim 1 , wherein an amount of the photosensitizers is in a range from 0.05 μM to 1000 μM, wherein the photosensitizers are contained within the netting or on exterior surfaces of the netting, and wherein the amount of the photosensitizers generates the cloud of singlet oxygen in response to 100 lux or more of the incident light photoactivating the photosensitizers for 60 minutes or more. 4. The antimicrobial preventive netting of claim 1 , wherein the photosensitizers, further comprise electrically charging one or more photosensitizers to attract and retain opposite electrically charged microbial particles and/or microbial droplets for inactivation. 5. The antimicrobial preventive netting of claim 1 , wherein the plurality of openings through the antimicrobial preventive netting traverse across a thickness of the netting between the top surface and the bottom surface. 6. The antimicrobial preventive netting of claim 5 , further comprising one or more of fibers or threads running in two or more distinct directions such that the one or more fibers or threads placed in a first direction are spaced apart, and the one or more fibers or threads placed in a second direction are spaced apart to define an arrangement of the plurality of openings through the antimicrobial preventive netting. 7. The antimicrobial preventive netting of claim 1 , further comprises one or more electret materials including one or more of synthetic polymers, fluoropolymers, polypropylene, or polyethyleneterephthalate. 8. The antimicrobial preventive netting of claim 1 , further comprises one or more of a metallic material, a conductive material, a composite material, a ceramic material, or a three dimensional printed material. 9. The antimicrobial preventive netting of claim 1 , further comprising: a light source; and wherein a ratio of two or more photosensitizers is based on a quantum yield of each of the two or more photosensitizers in response to a waveband of incident light emitted by the light source. 10. The antimicrobial preventive netting of claim 1 , further comprising: a frame that forms one or more of an enclosure or a screen, wherein the frame is capable of supporting the antimicrobial preventive netting as it covers one or more surfaces of the enclosure or the screen. 11. The antimicrobial preventive netting of claim 10 , wherein the frame further comprises: one or more telescoping rods, hinged rods, or flexible metal wire. 12. The antimicrobial preventive netting of claim 1 , further comprising: headgear for a user, wherein the antimicrobial preventive netting is connected to one or more portions of the headgear and is capable of covering a face of the user. 13. A method of making antimicrobial preventive netting, comprising: placing the netting within a container having a body defining a cavity; adding a solution of photosensitizers inside the cavity of the container; and rotating the container to enable the solution of the photosensitizers to be deposited on each surface of the netting, and wherein a plurality of openings are defined through the netting to produce an antimicrobial preventive netting, comprising: the plurality of openings are between a top surface and a bottom surface of the netting; and photosensitizers that are distributed on the top surface, the bottom surface and through the plurality of openings, wherein the photosensitizers generate a cloud of singlet oxygen on the netting in response to incident light, wherein the photosensitizers include methylene blue, erythrosine, and riboflavin, wherein the amount of methylene blue is less than an amount of erythrosine or an amount of riboflavin, wherein a ratio of methylene blue to erythrosine to riboflavin is 1:2:2. 14. The method of claim 13 , wherein the container is made from a metal, and the method further comprising electrically charges the netting by rotating the netting within the metal container. 15. The method of claim 14 , further comprising reapplying one or more photosensitizers to the antimicrobial preventive netting.
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