Carbon monoxide-releasing molecules for therapeutic applications and methods of making and using thereof
US-10300069-B2 · May 28, 2019 · US
Carbon-monoxide-releasing molecules and therapeutic applications thereof
US11420994B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-11420994-B2 |
| Application number | US-201716487402-A |
| Country | US |
| Kind code | B2 |
| Filing date | Nov 15, 2017 |
| Priority date | Nov 16, 2016 |
| Publication date | Aug 23, 2022 |
| Grant date | Aug 23, 2022 |
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- Title
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- Abstract
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Abstract
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Carbon monoxide-releasing organic molecules are described herein. The molecules can be synthesized prior to administration (e.g., ex vivo) or formed in vivo. In those embodiments where the molecules are formed in vivo, reactants are administered under physiological conditions and undergo a cycloaddition reaction to form a product which releases carbon monoxide. In applying such reactions for therapeutic applications in vivo, the cycloaddition and CO release typically occur only under near-physiological or physiological conditions. For example, in some embodiments, the cycloaddition reaction and/or release of carbon monoxide occur at a temperature of about 37° C. and pH of about 7.4. Pharmaceutical compositions and methods for release carbon monoxide are also described.
First claim
Opening claim text (preview).
What is claimed is: 1. A compound selected from the group consisting of: or a pharmaceutically acceptable salt thereof, wherein Ph represents phenyl and Ms represents methanesulfonyl. 2. A pharmaceutical composition comprising a compound according to claim 1 and a pharmaceutically acceptable excipient.
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having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, [IMAGE cpc-sch-C07C-0958.gif] groups,[IMAGE cpc-sch-C07C-0959.gif] groups, or[IMAGE cpc-sch-C07C-0960.gif] in the acid moiety · CPC title
having the sulfur atom of at least one of the thio groups bound to a carbon atom of a ring other than a six-membered aromatic ring of the carbon skeleton · CPC title
with the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a ring other than a six-membered aromatic ring · CPC title
Acyclic radicals, substituted by carbocyclic rings · CPC title
- A61P9/02Primary
Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives · CPC title
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- What does patent US11420994B2 cover?
- Carbon monoxide-releasing organic molecules are described herein. The molecules can be synthesized prior to administration (e.g., ex vivo) or formed in vivo. In those embodiments where the molecules are formed in vivo, reactants are administered under physiological conditions and undergo a cycloaddition reaction to form a product which releases carbon monoxide. In applying such reactions for th…
- Who is the assignee on this patent?
- Univ Georgia State Res Found
- What technology area does this patent fall under?
- Primary CPC classification A61P9/02. Mapped technology areas include Human Necessities.
- When was this patent published?
- Publication date Tue Aug 23 2022 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 1 related publication on this page (citations in our corpus or others sharing the same primary CPC).