Rapid isolation of cyclotron-produced gallium-68

Patent metadata

Field	Value
Publication number	US-11417439-B2
Application number	US-201716328171-A
Country	US
Kind code	B2
Filing date	Aug 28, 2017
Priority date	Aug 26, 2016
Publication date	Aug 16, 2022
Grant date	Aug 16, 2022

Abstract

Methods for rapid isolation of radionuclides (e.g., 68Ga) produced using a cyclotron and methods for recycling of the parent isotope (e.g., 68Zn) are disclosed. In one version of the method, a solution including a radionuclide (e.g., 68Ga) is created from a target including cations (e.g., 68Zn). The solution including the radionuclide is passed through a first column including a sorbent comprising a hydroxamate resin to adsorb the radionuclide on the sorbent, and the radionuclide is eluted off the sorbent. The cations (e.g., 68Zn) are recovered from a recovery solution that has passed through the first column by passing the recovery solution through a second column including a second sorbent comprising a cation exchange resin.

First claim

What is claimed is:

1. A method for producing a solution including a radionuclide, the method comprising:
(a) bombarding a target solution with protons to produce a solution including a radionuclide, wherein the radionuclide is 68 Ga;
(b) passing the solution including the radionuclide through a column including a sorbent to adsorb the radionuclide on the sorbent; and
(c) eluting the radionuclide off the sorbent,
wherein the sorbent comprises a hydroxamate resin, and
wherein pH of the solution including the radionuclide before passing the solution including the radionuclide through the column is between 5 and 7.

2. The method of claim 1 , wherein the target solution comprises 68 Zn-enriched zinc nitrate.

3. The method of claim 1 , wherein step (c) comprises eluting the radionuclide off the sorbent using hydrochloric acid.

4. The method of claim 1 ,
wherein step (c) comprises eluting the radionuclide off the sorbent with an amount of eluent of 5 milliliters or less, and
wherein the method takes 30 minutes or less.

5. The method of claim 1 , wherein step (b) comprises adjusting pH of the solution including the radionuclide before passing the solution including the radionuclide through the column.

6. The method of claim 5 , wherein the adjusting of the pH comprises a dilution with water.

7. The method of claim 5 , wherein the adjusting of the pH comprises an addition of a base, and wherein the base forms a soluble product with 68 Ga and 68 Zn.

8. The method of claim 1 , wherein yield of the radionuclide from the solution including the radionuclide is greater than 80% by radioactivity.

9. The method of claim 1 , wherein the hydroxamate resin comprises hydroxamate groups bonded to a backbone comprising a material selected from the group consisting of silica, polymer coated silica, polyacrylate, and polystyrene, and wherein the hydroxamate resin has a particle size in a range of 10 to 100 microns.

10. The method of claim 1 , wherein the hydroxamate resin comprises hydroxamate groups bonded to a backbone comprising an acrylic acid/acrylamide coated silica having a diol bonded phase.

11. A method for producing a solution including a radionuclide, the method comprising:
(a) bombarding a solid target with protons to produce a solid radionuclide,
wherein the radionuclide is 68 Ga;
(b) creating a solution including the radionuclide from the solid radionuclide;
(c) passing the solution including the radionuclide through a column including a sorbent to adsorb the radionuclide on the sorbent; and
(d) eluting the radionuclide off the sorbent,
wherein the sorbent comprises a hydroxamate resin, and
wherein pH of the solution including the radionuclide before passing the solution including the radionuclide through the column is between 5 and 7.

12. The method of claim 11 , wherein the solution comprises 68 Zn-enriched zinc nitrate.

13. The method of claim 11 , wherein step (c) comprises eluting the radionuclide off the sorbent using hydrochloric acid.

14. The method of claim 11 ,
wherein step (c) comprises eluting the radionuclide off the sorbent with an amount of eluent of 5 milliliters or less, and
wherein the method takes 30 minutes or less.

15. The method of claim 11 , wherein step (b) comprises adjusting pH of the solution including the radionuclide before passing the solution including the radionuclide through the column.

16. The method of claim 15 , wherein the adjusting of the pH comprises a dilution.

17. The method of claim 15 , wherein the adjusting of the pH comprises an addition of a base, and wherein the base forms a soluble product with 68 Ga and 68 Zn.

18. The method of claim 11 , wherein yield of the radionuclide from the solution including the radionuclide is greater than 80%.

19. The method of claim 11 , wherein the hydroxamate resin comprises hydroxamate groups bonded to a backbone comprising a material selected from the group consisting of silica, polymer coated silica, polyacrylate, and polystyrene, and wherein the hydroxamate resin has a particle size in a range of 10 to 100 microns.

20. The method of claim 11 , wherein the hydroxamate resin comprises hydroxamate groups bonded to a backbone comprising an acrylic acid/acrylamide coated silica having a diol bonded phase.

Assignees

• Mayo Found Medical Education & Res

Inventors

• Pandey Mukesh K
• Degrado Timothy R

Classifications

• C01G15/00

  Compounds of gallium, indium or thallium · CPC title

• G21G1/001 Primary

  Recovery of specific isotopes from irradiated targets · CPC title

• G21G2001/0021

  Gallium · CPC title

• G21G2001/0094

  Other isotopes not provided for in the groups listed above · CPC title

• C01P2006/44

  Alpha, beta or gamma radiation related properties · CPC title