Numerical model of the human head

Patent metadata

Field	Value
Publication number	US-11416653-B2
Application number	US-201916412709-A
Country	US
Kind code	B2
Filing date	May 15, 2019
Priority date	May 15, 2019
Publication date	Aug 16, 2022
Grant date	Aug 16, 2022

Abstract

Systems and methods for generating a numerical model of the human head are provided. A numerical model may be created by generating a data array in a magnetic resonance modeling system, each cell of the array corresponding to a location in the head. The cells may be grouped into one or more regions, each group corresponding to a segment of the head. The cells of the array may be populated with values corresponding to tissue properties relevant to MR imaging. Tissue property values may be selected for each region based on one or more probability distributions. For each region and each tissue property, a value may be selected based on a corresponding probability distribution. Selected tissue property values may be input into cells in the array corresponding to the region with which the probability distribution is associated. The numerical model may be used as an input to an MRI simulator.

First claim

The invention claimed is:

1. A method for generating a numerical model of a human head, comprising:
generating an array in a memory of a magnetic resonance modeling system, each cell in the array corresponding to a location in the head, wherein generating the array comprises:
grouping cells of the array that correspond to different segments of the head, wherein a number of cells belonging to a group is based on one or more characteristics of the segment of the head associated with the grouped cells; and
populating the grouped cells of the array to generate a numerical model using one or more probability distributions of tissue property values of a head, wherein the probability distributions comprise tissue property values associated with locations in the head and corresponding probability values, and wherein populating the grouped cells comprises:
for each group of cells, determining a tissue property value based on one or more probability distributions associated with the segment of the head to which the group of cells corresponds.

2. The method of claim 1 , comprising inputting the numerical model into an MRI simulator to generate a simulated magnetic resonance image based on a simulated pulse sequence.

3. The method of claim 2 , comprising reconstructing an estimate of the tissue property values selected from the one or more probability distributions based on the simulated pulse sequence.

4. The method of claim 3 , comprising comparing the reconstructed estimate of the tissue property values to the tissue property values on which the numerical model is based.

5. The method of claim 4 , comprising adjusting the simulated MRI pulse sequence based on differences between the reconstructed estimate of the tissue property values and the tissue property values on which the numerical model is based.

6. The method of claim 2 , comprising:
comparing the simulated magnetic resonance image with an output of a clinical MRI machine; and
calibrating the clinical MRI machine based on differences between the simulated magnetic resonance image and the output of the clinical MRI machine.

7. The method of claim 1 , wherein populating the grouped cells of the array further comprises inputting the determined tissue property value into the corresponding cells.

8. The method of claim 1 , wherein the probability distributions comprise Gaussian distributions based on one or more measurements of tissue property values.

9. The method of claim 1 , wherein populating the grouped cells of the array using one or more probability distributions of tissue property values of a head comprises selecting, for each group of cells, a probability distribution corresponding to a tissue property.

10. The method of claim 1 , wherein the tissue property value is randomly selected based on the one or more probability distributions.

11. The method of claim 1 , wherein at least one group of cells corresponds to a neuropathology.

12. The method of claim 1 , wherein populating the grouped cells of the array further comprises selecting a probability distribution from a plurality of libraries of probability distributions, each library of probability distributions comprising tissue property values derived from a different measurements.

13. The method of claim 1 , wherein the probability distributions comprise tissue property values corresponding to a tissue property selected from the group consisting of electromagnetic tissue property susceptibility, iron concentration, real oximetry, tissue molecular composition, T1, T2, or T2*.

14. The method of claim 1 , wherein the magnetic resonance modeling system is an MRI simulator.

15. The method of claim 1 , wherein the cells composing the one or more groups of cells correspond to adjacent locations in the head.

16. The method of claim 15 , comprising adjusting a boundary of at least one of the one or more groups of cells by adding or removing at least one cell.

17. A electronic system comprising:
one or more processors;
one or more memories; and
one or more programs, wherein the one or more programs are stored in the one or more memories and configured to be executed by the one or more processors, the one or more programs including instructions for:
generating an array in the one or more memories, each cell in the array corresponding to a location in a head, wherein generating the array comprises:
grouping cells of the array that correspond to different segments of the head, wherein a number of cells belonging to a group is based on one or more characteristics of the segment of the head associated with the grouped cells; and
populating the grouped cells of the array to generate a numerical model using one or more probability distributions of tissue property values of a head, wherein the probability distributions comprise tissue property values associated with locations in the head and corresponding probability values, and wherein populating the grouped cells comprises:
for each group of cells, determining a tissue property value based on one or more probability distributions associated with the segment of the head to which the group of cells corresponds.

18. A non-transitory computer-readable storage medium storing instructions for generating a numerical model of a human head, the instructions configured to be executed by one or more processors of a system comprising a display, and one or more processors, the instructions configured to cause the system to:
generate an array in a memory of a magnetic resonance modeling system, each cell in the array corresponding to a location in the head, wherein generating the array comprises:
grouping cells of the array that correspond to different segments of the head, wherein a number of cells belonging to a group is based on one or more characteristics of the segment of the head associated with the grouped cells; and
populating the grouped cells of the array to generate a numerical model using one or more probability distributions of tissue property values of a head, wherein the probability distributions comprise tissue property values associated with locations in the head and corresponding probability values, and wherein populating the grouped cells comprises:
for each group of cells, determining a tissue property value based on one or more probability distributions associated with the segment of the head to which the group of cells corresponds.

Assignees

• Mitre Corp

Inventors

• Downs Matthew E
• Dagher Joseph

Classifications

• A61B5/055

  involving electronic [EMR] or nuclear [NMR] magnetic resonance, e.g. magnetic resonance imaging · CPC title

• G06N7/01

  Probabilistic graphical models, e.g. probabilistic networks · CPC title

• G06F17/18

  for evaluating statistical data {, e.g. average values, frequency distributions, probability functions, regression analysis (forecasting specially adapted for a specific administrative, business or logistic context G06Q10/04)} · CPC title

• A61B5/7267

  involving training the classification device · CPC title

• G06F30/20 Primary

  Design optimisation, verification or simulation (optimisation, verification or simulation of circuit designs G06F30/30) · CPC title