Anti-CCL17 antibodies
US-9944697-B2 · Apr 17, 2018 · US
Anti-CCL17 antibodies
US11414484B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-11414484-B2 |
| Application number | US-202017060362-A |
| Country | US |
| Kind code | B2 |
| Filing date | Oct 1, 2020 |
| Priority date | Nov 6, 2013 |
| Publication date | Aug 16, 2022 |
| Grant date | Aug 16, 2022 |
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- Title
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Abstract
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The present invention relates to antibodies specifically binding CCL17, polynucleotides encoding the antibodies or fragments, and methods of making and using the foregoing.
First claim
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We claim: 1. An isolated polynucleotide encoding an antibody that specifically binds human CCL17, wherein the polynucleotide encodes a heavy chain complementarity determining region (HCDR) 1, a HCDR2, and a HCDR3, and a light chain complementarity determining region (LCDR) 1, a LCDR2, and a LCDR3 of SEQ ID NOs: 4, 5, 42, 8, 24 and 28, respectively. 2. The isolated polynucleotide of claim 1 , wherein the polynucleotide encodes a heavy chain variable region (VH) of SEQ ID NO: 46 and a light chain variable region (VL) of SEQ ID NO: 62. 3. A vector comprising the isolated polynucleotide of claim 1 . 4. A host cell comprising the vector of claim 2 . 5. A method of producing an antibody, comprising culturing the host cell of claim 3 in conditions such that the antibody is produced. 6. The isolated polynucleotide of claim 1 , wherein the polynucleotide comprises one or more regulatory elements. 7. The isolated polynucleotide of claim 6 , wherein the regulatory element includes an enhancer or promoter. 8. The isolated polynucleotide of claim 1 , wherein the encoded antibody is human or humanized. 9. The isolated polynucleotide of claim 1 , wherein the encoded antibody is of IgG1, IgG2, IgG3, or IgG4 isotype. 10. The isolated polynucleotide of claim 1 , wherein the encoded antibody comprises a substitution in an Fc region. 11. The isolated polynucleotide of claim 10 , wherein the substitution comprises V234A, G237A, P238S, H268A, V309L, A330S, or P331S substitution on IgG2, or S228P, L234A, or L235A substitution on IgG4, wherein residue numbering is according to the EU Index. 12. The isolated polynucleotide of claim 11 , wherein the substitution comprises V234A/G237A/P238S/H268A/V309L/A330S/P331S substitution on IgG2 or S228P/L234A/L235A substitution on IgG4, wherein residue numbering is according to the EU Index.
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Classifications
variable (Fv) region, i.e. VH and/or VL · CPC title
comprising antibodies · CPC title
Cytokines; Lymphokines; Interferons · CPC title
Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value · CPC title
Antagonist effect on antigen, e.g. neutralization or inhibition of binding · CPC title
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Frequently asked questions
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- What does patent US11414484B2 cover?
- The present invention relates to antibodies specifically binding CCL17, polynucleotides encoding the antibodies or fragments, and methods of making and using the foregoing.
- Who is the assignee on this patent?
- Janssen Biotech Inc
- What technology area does this patent fall under?
- Primary CPC classification C07K16/24. Mapped technology areas include Chemistry & Metallurgy.
- When was this patent published?
- Publication date Tue Aug 16 2022 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 1 related publication on this page (citations in our corpus or others sharing the same primary CPC).