Method for diluting a sample liquid and dilution unit for a subsequent analysis

Patent metadata

Field	Value
Publication number	US-11397141-B2
Application number	US-201916703007-A
Country	US
Kind code	B2
Filing date	Dec 4, 2019
Priority date	Dec 5, 2018
Publication date	Jul 26, 2022
Grant date	Jul 26, 2022

Abstract

The present disclosure relates to a method for diluting a sample liquid taken from a sampling point for the subsequent determination of a parameter which depends on a concentration of at least one analyte in the sample liquid, including: supplying a first quantity of the sample liquid to a mixing device via a first sample liquid line; supplying a second quantity of the sample liquid to a separator via a second sample liquid line; separating the analyte from the second quantity of the sample liquid supplied to the separator by means of the separator to obtain a dilution liquid that no longer contains the analyte, and mixing at least one portion of the first quantity of the sample liquid supplied to the mixing device via the first sample liquid line with at least one portion of the dilution liquid by means of the mixing device.

First claim

The invention claimed is:

1. A method for diluting a sample liquid taken from a sampling point of an environmental or industrial process for subsequent determination of a parameter that depends on a concentration of at least one analyte in the sample liquid, the method comprising:
supplying a first quantity of the sample liquid to a mixing device via a first sample liquid line;
supplying a second quantity of the sample liquid to a separator via a second sample liquid line, wherein the first quantity and the second quantity are supplied from the sampling point;
separating at least the at least one analyte from the second quantity of the sample liquid supplied to the separator using the separator to generate a dilution liquid that is substantially free of the at least one analyte;
mixing at least one portion of the first quantity of the sample liquid supplied to the mixing device via the first sample liquid line with at least one portion of the dilution liquid using the mixing device; and
subsequently determining at least one measured value of the parameter of the sample liquid, which depends on the concentration of the at least one analyte in the sample liquid.

2. The method of claim 1 , wherein the first quantity of the sample liquid flows through the first sample liquid line with a first mass or volume flow rate, and wherein the second quantity of the sample liquid flows through the second sample liquid line with a second mass or volume flow rate that is different from the first mass or volume flow rate.

3. The method of claim 1 , wherein the separating of at least the at least one analyte from the second quantity of the sample liquid is effected using a physical or chemical method.

4. The method of claim 3 , wherein the physical method is a thermal method or a mechanical method.

5. The method of claim 1 , wherein the separating of at least the at least one analyte from the second quantity of the sample liquid is effected by distillation.

6. The method of claim 1 , wherein the sample liquid contains water, and the at least one analyte is dissolved and/or suspended in the water, and wherein the separating of the at least one analyte from the second quantity of the sample liquid comprises:
discharging water vapor from the sample liquid; and
cooling the water vapor to form condensate, the condensate serving as the dilution liquid.

7. The method of claim 1 , wherein the separating of at least the at least one analyte comprises passing the sample liquid through an ion exchanger configured such that the at least one analyte is sorbed by the ion exchanger, wherein liquid exiting the ion exchanger after passing therethrough is the dilution liquid.

8. The method of claim 1 , the method further comprising:
storing the dilution liquid in a container, wherein the at least one portion of the dilution liquid used in the mixing device is from the container.

9. A method for determining a parameter of a sample liquid which depends on a concentration of at least one analyte in the sample liquid, the method comprising:
taking sample liquid from a sampling point of an environmental or industrial process;
preparing diluted sample liquid, wherein the preparing comprising:
supplying a first quantity of the sample liquid to a mixing device via a first sample liquid line;
supplying a second quantity of the sample liquid to a separator via a second sample liquid line;
separating at least the at least one analyte from the second quantity of the sample liquid supplied to the separator using the separator to generate a dilution liquid that no longer contains the at least one analyte; and
mixing at least one portion of the first quantity of the sample liquid supplied to the mixing device via the first sample liquid line with at least one portion of the dilution liquid to produce a diluted sample liquid using the mixing device;

transporting at least one portion of the diluted sample liquid to a measuring unit; and
determining at least one measured value of the parameter using the measuring unit.

10. The method of claim 9 , further comprising:
producing a reaction mixture from the at least one portion of the diluted sample liquid and at least one reagent;
generating a measurement signal that represents a measured variable of the reaction mixture correlated with the parameter to be determined using the measuring unit; and
deriving the measured value of the parameter from the measurement signal.

11. The method of claim 9 , wherein all the method steps are performed in an automated manner using a control electronics.

12. A dilution unit for a measuring device for determining measured values of a parameter that depends on a concentration of at least one analyte in a sample liquid, the dilution unit comprising:
a first sample liquid line that is fluidly connectable to a sampling point containing the sample liquid;
a second sample liquid line that is fluidly connectable to the sampling point, wherein the sampling point is in an environmental or industrial process;
a separator fluidly connected to the second sample liquid line and configured to separate the at least one analyte from sample liquid supplied to the separator via the second sample liquid line to produce a dilution liquid that is substantially free of the at least one analyte, wherein the separator includes a container;
an outlet fluidly connected to the container and configured to enable discharge of the dilution liquid;
a mixing device fluidly connected to the outlet of the container and to the first sample liquid line; and
means for transporting sample liquid to the separator, for transporting dilution liquid from the separator, and for transporting sample liquid from the sampling point to the mixing device.

13. The dilution unit of claim 12 , wherein the separator includes:
a gas discharge line connecting the container to a condensation unit.

14. The dilution unit of claim 13 , wherein the container is a heatable container.

15. The dilution unit of claim 13 , wherein the condensation unit includes:
a cooler configured for cooling gas supplied from the condensation unit via the gas discharge line; and
a condensate container configured for collecting condensate from the cooled gas, wherein the condensate container is fluidly connectable to the mixing device as to supply the condensate thereto as dilution liquid.

16. The dilution unit of claim 13 , wherein the separator further includes a gas supply line opening into the container.

17. The dilution unit of claim 13 , wherein the gas supply line is a heatable gas supply line.

18. The dilution unit of claim 13 , wherein the separator includes a heater configured to interact with the container.

19. The dilution unit of claim 13 , wherein the at least one analyte is an ion, and wherein the separator includes an ion exchanger fluidly connected to the second sample liquid line and the outlet and configured for sorbing the at least one analyte.

20. An automatic measuring device for determining measured values of a parameter that depends on a concentration of at least one analyte in a sample liquid, the measuring device comprising:
a dilution unit comprising:
a first sample liquid line that is fluidly connectable to a sampling point containing the sample liquid;
a second sample liquid line that is fluidly connectable to the sampling point, wherein the sampling point is in an environmental or industrial process;
a separator fluidly connected to the second sample liquid line and configured to separate the at le

Assignees

• Endress Hauser Conducta Gmbh Co Kg

Inventors

• Kathe Ulrich
• Rottensteiner Ulrich
• Schweitzer Daniel

Classifications

• G01N35/1002

  Reagent dispensers · CPC title

• G01N2001/386

  Other diluting or mixing processes · CPC title

• G01N35/00

  Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor · CPC title

• G01N35/02

  using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations {(G01N35/0098 and G01N35/0099 take precedence)} · CPC title

• G01N1/18

  with provision for splitting samples into portions (G01N1/12, G01N1/14 take precedence; fraction-collection apparatus for chromatography B01D15/08) · CPC title