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Polymers including galactose based blocks and uses thereof
US11396571B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-11396571-B2 |
| Application number | US-201615166634-A |
| Country | US |
| Kind code | B2 |
| Filing date | May 27, 2016 |
| Priority date | May 28, 2015 |
| Publication date | Jul 26, 2022 |
| Grant date | Jul 26, 2022 |
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- Title
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- Abstract
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Abstract
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Block copolymers that include one or more galactose based blocks and one or more cationic blocks; polyplexes including disclosed block copolymers and one or more nucleic acids; and methods of delivering a nucleic acid to a cell which can include delivering a polyplex to the cell.
First claim
Opening claim text (preview).
The invention claimed is: 1. A block copolymer comprising: one or more N-acetyl-D-galactosamine (GNA) based blocks; and one or more cationic blocks. 2. The block copolymer according to claim 1 , wherein the one or more cationic blocks comprise aminoethylmethacrylamide (AEMA), 3-guanidinopropyl methacrylamide (GPMA), or combinations thereof. 3. The block copolymer according to claim 1 , wherein the one or more N-acetyl-D-galactosamine (GNA) based block comprises methacrylamido N-acetyl-D-galactosamine (MAGalNAc). 4. The block copolymer according to claim 1 , wherein there are at least 10 repeating units of the cationic block. 5. The block copolymer according to claim 1 , wherein there are at least 30 repeating units of the cationic block. 6. The block copolymer according to claim 1 , wherein there are at least 40 repeating units of the N-acetyl-D-galactosamine (GNA) based block. 7. The block copolymer according to claim 1 , wherein there are at least 60 repeating units of the N-acetyl-D-galactosamine (GNA) based block. 8. A polyplex comprising: a block copolymer comprising: one or more N-acetyl-D-galactosamine (GNA) based blocks; and one or more cationic blocks; and one or more nucleic acids. 9. The polyplex according to claim 8 , wherein the one or more cationic blocks comprise aminoethylmethacrylamide (AEMA), 3-guanidinopropyl methacrylamide (GPMA), or combinations thereof. 10. The polyplex according to claim 8 , wherein the one or more N-acetyl-D-galactosamine (GNA) based block comprises methacrylamido N-acetyl-D-galactosamine (MAGalNAc). 11. The polyplex according to claim 8 , wherein there are at least 10 repeating units of the cationic block. 12. The polyplex according to claim 8 , wherein there are at least 40 repeating units of the N-acetyl-D-galactosamine (GNA) based block. 13. A method of delivering a nucleic acid to a cell, the method comprising: delivering a polyplex to a cell, the polyplex comprising: a block copolymer comprising: one or more N-acetyl-D-galactosamine (GNA) based blocks; and one or more cationic blocks; and one or more nucleic acids. 14. The method according to claim 13 , wherein the one or more cationic blocks comprise aminoethylmethacrylamide (AEMA), 3-guanidinopropyl methacrylamide (GPMA), or combinations thereof. 15. The method according to claim 13 , wherein the one or more N-acetyl-D-galactosamine (GNA) based block comprises methacrylamido N-acetyl-D-galactosamine (MAGalNAc). 16. The method according to claim 13 , wherein there are at least 10 repeating units of the cationic block. 17. The method according to claim 13 , wherein there are at least 40 repeating units of the N-acetyl-D-galactosamine (GNA) based block.
Assignees
Inventors
Classifications
- A61K31/713Primary
Double-stranded nucleic acids or oligonucleotides · CPC title
Polycationic oligopeptides, polypeptides or polyamino acids, e.g. for complexing nucleic acids · CPC title
Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation · CPC title
Sugars, nucleosides, nucleotides or nucleic acids · CPC title
on to polymers obtained by ring-opening polymerisation of carbocyclic compounds having one or more carbon-to-carbon double bonds in the carbocyclic ring, i.e. polyalkeneamers {(C08F283/004 takes precedence)} · CPC title
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- What does patent US11396571B2 cover?
- Block copolymers that include one or more galactose based blocks and one or more cationic blocks; polyplexes including disclosed block copolymers and one or more nucleic acids; and methods of delivering a nucleic acid to a cell which can include delivering a polyplex to the cell.
- Who is the assignee on this patent?
- Univ Minnesota
- What technology area does this patent fall under?
- Primary CPC classification A61K31/713. Mapped technology areas include Human Necessities.
- When was this patent published?
- Publication date Tue Jul 26 2022 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 8 related publications on this page (citations in our corpus or others sharing the same primary CPC).