Cyclic peptide analogs of melanocortin and amanitin and methods of making such

Patent metadata

Field	Value
Publication number	US-11396535-B2
Application number	US-202016804465-A
Country	US
Kind code	B2
Filing date	Feb 28, 2020
Priority date	Mar 1, 2019
Publication date	Jul 26, 2022
Grant date	Jul 26, 2022

Abstract

The invention described herein is based in part on the discovery of a protein/peptide crosslink, which introduces fluorescent properties, and which has been applied to synthesize analogues of melanocortin and amanitin as choice peptides to be explored in the context of isoindole peptides. Without limitation, it is expected that those trained in the art of peptide synthesis and stapling would appreciate the consequences of this invention such that other peptides of varied length can be similarly constrained by isoindole staples as featured herein.

First claim

What is claimed is:

1. A compound of Formula IV a-d

Assignees

• Univ British Columbia
• Provincial Health Services Authority

Inventors

• Perrin David
• Todorovic Mihajlo
• Bénard Francois
• Zhang Chengcheng

Classifications

• C07K14/685 Primary

  Alpha-melanotropin · CPC title

• C07K14/72

  for hormones {(for neuromediators C07K14/70571)} · CPC title

• A61K38/00

  Medicinal preparations containing peptides (peptides containing beta-lactam rings A61K31/00; cyclic dipeptides not having in their molecule any other peptide link than those which form their ring, e.g. piperazine-2,5-diones, A61K31/00; ergot alkaloids of the cyclic peptide type A61K31/48; containing macromolecular compounds having statistically distributed amino acid units A61K31/74; medicinal preparations containing antigens or antibodies A61K39/00; medicinal preparations characterised by the non-active ingredients, e.g. peptides as drug carriers, A61K47/00) · CPC title

• C07K14/68 Primary

  Melanocyte-stimulating hormone [MSH] · CPC title

• C07K7/56

  the cyclisation not occurring through 2,4-diamino-butanoic acid · CPC title