Microfluidic movement control method utilizing light

Patent metadata

Field	Value
Publication number	US-11396014-B2
Application number	US-201916265931-A
Country	US
Kind code	B2
Filing date	Feb 1, 2019
Priority date	Aug 2, 2016
Publication date	Jul 26, 2022
Grant date	Jul 26, 2022

Abstract

A microfluidic movement control method utilizing light, a device, and a microtubule actuator (2). The microtubule actuator (2) is prepared by utilizing a light-induced deformed smart polymer material. The smart polymer material forms, by an exciting beam, asymmetrical deformation, and is induced to produce a capillary action to drive a microfluid movement. The embodiment can drive microfluids having various polarities and compositions, and can drive creep of the microfluid, and can even drive the microfluid to generate a 3D movement trail. The embodiment has found a wide range of potential applications in controllable microfluidic transport, micro-reaction systems, micro-mechanic systems, IC laboratories, and others.

First claim

We claim:

1. A method for light-controlled microfluidic movement, comprising the steps of:
providing a microchannel actuator having a channel wall, wherein the microchannel actuator has an outer diameter of 0.0012-2 mm and an inner diameter of 0.001-1.99 mm, and wherein the material of the channel wall of the microchannel actuator is a polymer material containing an azobenzene group or an azo group;
loading a micro-fluid into the microchannel actuator; and
illuminating one end of the micro-fluid-loaded microchannel actuator by a light source to drive the micro-fluid to move to an other end of the microchannel actuator; or
illuminating the micro-fluid-loaded microchannel actuator with light sources of different intensities to drive the micro-fluid to move from an end receiving a high intensity light towards the direction of a low intensity light; and
wherein the microchannel actuator undergoes asymmetric deformation under light stimulation, which induces capillary forces to drive microfluidic movement; and
wherein illuminating the micro-fluid-loaded microchannel actuator causes the cross-sectional area of the microchannel actuator at the position of illumination to change, thereby driving the micro-fluid to move toward a thinner end of the microchannel actuator.

2. The method according to claim 1 , wherein said microchannel actuator comprises a substrate having a groove and a film, and wherein said groove and film together form a fluid channel; and wherein said substrate and/or film contain an effective amount of the material of the channel wall.

3. The method according to claim 1 , wherein the material of the channel wall is prepared by homopolymerization or copolymerization of CAB monomers; wherein the chemical structure of the monomer CAB is:

wherein, R 2 is H, a C1, C2, C3, C4, C5, or C6 hydrocarbyl or alkoxy, or a polar terminal group selected from the group consisting of a cyano, an isocyano, a hydroxyl, a halogen, an R 1 is a C3, C4, C5, C6, C7, C8, C9, C10, C11, or C12 hydrocarbyl or alkoxy;
wherein D is absent or present in the monomer, and wherein, when D is present, D is selected from the following structure formula (1)-structure formula (4):

wherein R 3 is a C2, C3, C4, C5, or C6 hydrocarbyl or alkoxy.

4. The method according to claim 1 , wherein the material of the channel wall is prepared by copolymerizing a CAB monomer with a CF monomer, wherein the chemical structure of the monomer CAB is:

and wherein the chemical structure formula of the CF monomer is selected from the group consisting of:

wherein, R 2 is H, a C1, C2, C3, C4, C5, or C6 hydrocarbyl or alkoxy, or a polar terminal group selected from the group consisting of a cyano, an isocyano, a hydroxyl, a halogen, an ester group, a carboxyl, a nitro, an amino and an amide group;
R 1 is a C3, C4, C5, C6, C7, C8, C9, C10, C11, or C12 hydrocarbyl or alkoxy;
wherein D is absent or present in the monomer, and wherein, when D is present, D is selected from the following structure formula (1)-structure formula (4):

wherein R 3 is a C2, C3, C4, C5, or C6 hydrocarbyl or alkoxy, and wherein the structure of G is selected from the following structures or combinations thereof:

5. The method according to claim 3 , wherein the material of the channel wall comprises a structural unit as follows:

wherein, R 2 is H, a C1, C2, C3, C4, C5, or C6 hydrocarbyl or alkoxy, or a polar terminal group selected from the group consisting of a cyano, a isocyano, a hydroxyl, a halogen, an ester group, a carboxyl, a nitro, an amino and an amide group;
R 1 is a C3, C4, C5, C6, C7, C8, C9, C10, C11, or C12 hydrocarbyl or alkoxy;
D is selected from one of the following structure formula (1)-structure formula (4):

wherein, R 3 is a C2, C3, C4, C5 or C6 alkylene, alkenylene, alkynylene or an alkyleneoxy group.

6. The method according to claim 1 , wherein the micro-fluid is a hydrophilic micro-fluid or a hydrophobic micro-fluid.

7. The method according to claim 1 , wherein the micro-fluid is selected from the group consisting of organic liquids, water, aqueous solutions, gas-liquid fluids, liquid-solid fluids or emulsions.

8. The method according to claim 1 , wherein the light source is selected from the group consisting of ultraviolet light, visible light, near infrared light and a combination thereof.

9. The method according to claim 1 , wherein the method controls the direction of the microfluidic movement by controlling the direction of movement of the light or the direction of attenuation of the light.

10. The method according to claim 1 , wherein the method adjusts the driving rate of the micro-fluid by controlling the intensity of the light source.

11. The method according to claim 1 , wherein the whole or part of the material of the wall of the microchannel actuator is a polymer material containing an azobenzene group or an azo group.

12. The method according to claim 1 , wherein the microchannel actuator further includes a composite layer wrapped around the inside and/or outside of the channel wall.

13. The method according to claim 1 , wherein the microchannel actuator has an outer diameter of 0.01-2 mm.

14. A device for light-controlled microfluidic movement, comprising a light source and a microchannel actuator; wherein the microchannel actuator has a channel wall with an outer diameter of 0.0012-2 mm and an inner diameter is 0.001 to 1.99 mm, and the material of the channel wall of the microchannel actuator is a polymer material containing an azobenzene or azo group;
wherein the microchannel actuator undergoes asymmetric deformation under light stimulation, which induces capillary forces to drive microfluidic movement; and
wherein illuminating the micro-fluid-loaded microchannel actuator with a light source causes the cross-sectional area of the microchannel actuator at the position of illumination to change, thereby driving the micro-fluid to move toward a thinner end of the microchannel actuator.

15. The device according to claim 14 , wherein the irradiation position of the light source can be moved along the microchannel actuator; and/or
an attenuator is placed between the light source and the microchannel actuator.

16. The device according to claim 14 , wherein the microchannel actuator has an outer diameter of 0.01-2 mm.

17. The micro-channel actuator for light-controlled microfluidic movement according to claim 14 , wherein the microchannel actuator has an outer diameter of 0.01-2 mm.

18. A micro-channel actuator for light-controlled microfluidic movement, comprising:
a microchannel actuator with a channel wall having an outer diameter of 0.0012-2 mm and an inner diameter of

Assignees

• Univ Fudan

Inventors

• Yu Yanlei
• Lv Jiuan
• Wei Jia
• Liu Yuyun

Classifications

• B01L3/50273 Primary

  characterised by the means or forces applied to move the fluids · CPC title

• B01L2400/0406

  capillary forces · CPC title

• C08G61/08

  of carbocyclic compounds containing one or more carbon-to-carbon double bonds in the ring · CPC title

• B01L2400/0493

  Specific techniques used · CPC title

• C08G2261/1642

  comprising reactive double bonds or triple bonds · CPC title