System and method for radiotherapy treatment planning and delivery

Patent metadata

Field	Value
Publication number	US-11389669-B2
Application number	US-201917044497-A
Country	US
Kind code	B2
Filing date	Apr 1, 2019
Priority date	Apr 3, 2018
Publication date	Jul 19, 2022
Grant date	Jul 19, 2022

Abstract

A method of radiotherapy treatment planning for creating a plan for delivery of radiation to a patient in at least one particle-based arc is proposed. The delivery time for the plan is reduced by including a penalty in the objective function, designed to limit the number of energy layers and/or the number of energy layer changes.

First claim

The invention claimed is:

1. A method of radiotherapy treatment planning for creating and applying a plan for delivery of at least one particle-based arc to a patient using an apparatus arranged to deliver radiation using charged particles from a number of different directions comprising the steps of:
a. determining at least one arc trajectory including a set of beam angles;
b. determining a set of energy layers for each beam angle;
c. optimizing the plan using an optimization problem formulation configured to produce a suitable dose distribution, in such a way that the plan will use only a subset of beam angles and a subset of energy layers from the set of beam angles and the set of energy layers, respectively, wherein the optimization is subject to at least one penalty configured to limit a number of the energy layers; and
d. storing in a data memory the plan which, when applied by the apparatus arranged to deliver radiation, limits each beam angle or each energy layer to an appropriate cross-section based on the stored plan.

2. The method according to claim 1 , wherein the at least one penalty is a constraint or a term in an objective function used in the optimization.

3. The method according to claim 1 , wherein the at least one penalty is based on of the number of energy layers.

4. The method according to claim 1 , wherein the at least one penalty is defined to act on an entire one of the at least one particle-based arc.

5. The method according to claim 1 , wherein the at least one penalty is defined to act on one or more sub-sets of one of the at least one particle-based arc, each sub-set comprising one or more beams.

6. The method according to claim 1 , wherein the plan is optimized using an optimization method configured to account for uncertainties during delivery.

7. The method according to claim 1 , further comprising the steps of applying a ripple filter in the at least one arc trajectory and controlling the ripple filter to spread the Bragg peak of the particles to limit the number of energy layers needed to create a robust plan.

8. A non-transitory computer-readable storage medium storing thereon a computer-readable code for controlling a radiotherapy planning apparatus, said computer readable code which when run in a processor of a radiotherapy planning apparatus causes the apparatus to perform the method according to claim 1 .

9. A radiotherapy treatment planning apparatus arranged to deliver a charged particles based arc therapy, the apparatus comprising a processor and a a non-transitory computer readable storage medium storing a computer-readable code according to claim 8 , configured to be run in the processor to control the radiotherapy treatment planning apparatus.

10. The method according to claim 1 , wherein the penalty is based on a number of energy layer changes between adjacent angles.

Assignees

• Raysearch Lab Ab

Inventors

• Traneus Erik
• Eriksson Kjell
• Engwall Erik
• Bokrantz Rasmus
• Fredriksson Albin

Classifications

• A61N5/1031 Primary

  using a specific method of dose optimization · CPC title

• A61N5/1081

  Rotating beam systems with a specific mechanical construction, e.g. gantries · CPC title

• G16H20/40

  relating to mechanical, radiation or invasive therapies, e.g. surgery, laser therapy, dialysis or acupuncture · CPC title

• A61N2005/1087

  Ions; Protons · CPC title