Methods of prognosis and treatment

Patent metadata

Field	Value
Publication number	US-11385241-B2
Application number	US-201716334033-A
Country	US
Kind code	B2
Filing date	Sep 27, 2017
Priority date	Sep 29, 2016
Publication date	Jul 12, 2022
Grant date	Jul 12, 2022

Abstract

A method of determining a management course for treating a subject showing symptoms of a disease is disclosed. The method comprises measuring the TRAIL protein level in a blood sample of the subject, wherein when the TRAIL level is below a predetermined amount, the subject is treated as a high-risk patient.

First claim

What is claimed is:

1. A method for triaging subjects comprising measuring the TRAIL protein level in a blood sample of a subject showing symptoms of an infectious disease, wherein the subject has a normal troponin level, and wherein when the TRAIL level is below 30 pg/ml, the subject is admitted to a hospital.

2. The method of claim 1 further comprising managing the subject with a management selected from the group consisting of mechanical ventilation, invasive monitoring, last-resort drug, sedation, intensive care admission and surgical intervention.

3. The method of claim 1 , wherein said blood sample is a fraction of whole blood.

4. The method of claim 3 , wherein said fraction is serum or plasma.

5. The method of claim 1 , wherein said blood sample comprises cells selected from the group consisting of lymphocytes, monocytes and granulocytes.

6. The method of claim 1 , wherein said measuring is determined electrophoretically or immunochemically.

7. The method of claim 6 , wherein said immunochemical determination is measured by lateral flow immunoassay, flow cytometry, radioimmunoassay, immunofluorescence or by an enzyme-linked immunosorbent assay.

8. The method of claim 1 , wherein the subject has an infectious disease.

9. The method of claim 1 , wherein the symptoms comprise fever.

10. The method of claim 1 , wherein the triaging further comprises measuring the level of at least one additional determinant selected from the group consisting of IP10, CRP, PCT, and IL-6.

11. The method of claim 1 , wherein when the TRAIL level is below 25 pg/ml, the subject is admitted to a hospital.

Assignees

• Memed Diagnostics Ltd

Inventors

• Eden Eran
• Oved Kfir
• Cohen-Dotan Assaf
• Navon Roy
• Boico Olga
• Paz Meital

Classifications

• C07K14/522

  Alpha-chemokines, e.g. NAP-2, ENA-78, GRO-alpha/MGSA/NAP-3, GRO-beta/MIP-2alpha, GRO-gamma/MIP-2beta, IP-10, GCP-2, MIG, PBSF, PF-4, KC · CPC title

• G01N33/6869

  Interleukin · CPC title

• G01N2333/52

  Assays involving cytokines · CPC title

• G01N33/6893 Primary

  related to diseases not provided for elsewhere · CPC title

• G16H50/20

  for computer-aided diagnosis, e.g. based on medical expert systems · CPC title