Analysis device

Patent metadata

Field	Value
Publication number	US-11385208-B2
Application number	US-201616083308-A
Country	US
Kind code	B2
Filing date	Mar 7, 2016
Priority date	Mar 7, 2016
Publication date	Jul 12, 2022
Grant date	Jul 12, 2022

Abstract

An analysis device of the present invention is provided with a sample introduction unit that introduces a sample into a mass spectroscope; a sample condensation unit that treats the sample introduced into the device; a detection unit that analyzes the sample treated by a treatment unit; and a control unit that controls the sample introduction unit, the sample condensation unit, and the detection unit. The sample introduction unit includes a sample introduction valve, and the sample condensation unit includes an elution valve and a cleaning valve, and the cleaning valve is disposed between the sample introduction valve and the elution valve.

First claim

The invention claimed is:

1. An analysis device for quantifying an analyte, comprising:
a sample introduction unit configured to introduce a sample into the analysis device;
a treatment unit configured to treat the sample introduced into the analysis device at the sample introduction unit;
a detection unit configured to analyze the sample treated by the treatment unit; and
a control unit configured to control the sample introduction unit, the treatment unit, and the detection unit, wherein
the sample introduction unit includes a sample introduction valve,
the treatment unit includes an elution valve and a cleaning valve,
the sample introduction valve feeds the sample to the elution valve through the cleaning valve,
the detection unit analyzes the sample which flew thereto via the sample introduction valve, the cleaning valve, and the elution valve in the order stated,
the control unit performs a control for switching positions of the cleaning valve and the elution valve so as to be directly connected to each other via a flow path pipe, such that only the flow path pipe is disposed between the cleaning valve and the elution valve, for cleaning the treatment unit even while the sample is being introduced into the analysis device by the sample introduction unit, and
while the sample is being eluted from the treatment unit to the detection unit, the control unit performs a control for switching the position of the sample introduction valve back and forth one time.

2. The analysis device according to claim 1 , further comprising:
a liquid feeding unit including a cleaning pump connected to the cleaning valve.

3. The analysis device according to claim 2 , wherein
the liquid feeding unit further includes: a sample introduction pump connected to the sample introduction valve and an elution pump connected to the elution valve.

4. The analysis device according to claim 3 , wherein
the treatment unit further includes a separation column,
the detection unit further includes a waste liquid valve,
the elution valve is connected to the separation column and the waste liquid valve,
the sample introduction pump feeds a solution to a flow path pipe between the sample introduction valve and the cleaning valve to clean the flow path pipe,
the cleaning pump feeds a solution to a flow path pipe between the cleaning valve and the elution valve to clean the flow path pipe, and
the elution pump feeds a solution to a flow path pipe between the elution valve and the waste liquid valve and the separation column to clean the flow path pipe and the separation column.

5. The analysis device according to claim 1 , further comprising:
a waste liquid valve between the detection unit and the elution valve.

6. The analysis device according to claim 1 , further comprising:
a liquid feeding unit including a cleaning pump connected to the cleaning valve, a sample introduction pump connected to the sample introduction valve, and an elution pump connected to the elution valve, wherein
the sample introduction unit further includes a syringe valve, a needle, and a sample loop,
the treatment unit further includes a separation column,
the detection unit further includes a waste liquid valve and a detector,
the sample introduction valve is connected to the sample introduction pump, the cleaning valve, the sample loop, the syringe valve, and the needle,
the cleaning valve is connected to the elution valve, the cleaning pump, the sample introduction valve, and a waste liquid flow path, and
the elution valve is connected to the cleaning valve, the waste liquid valve, the separation column, the elution pump, and the waste liquid flow path.

7. The analysis device according to claim 1 , further comprising:
a liquid feeding unit including a cleaning pump connected to the cleaning valve, a sample introduction pump connected to the sample introduction valve, and an elution pump connected to the elution valve, wherein
the sample introduction unit further includes a syringe valve, a needle, and a sample loop,
the treatment unit further includes a separation column,
the detection unit further includes a waste liquid valve and a detector,
the sample introduction valve is connected to the sample introduction pump, the cleaning valve, the sample loop, the syringe valve, and the needle,
the cleaning valve is connected to the elution valve, the elution pump, the sample introduction valve, and a waste liquid flow path, and
the elution valve is connected to the cleaning valve, the waste liquid valve, the separation column, the cleaning pump, and the waste liquid flow path.

Assignees

• Hitachi High Tech Corp

Inventors

• Nogami Makoto
• Ito Shinya

Classifications

• G01N30/24 Primary

  Automatic injection systems · CPC title

• G01N30/28

  Control of physical parameters of the fluid carrier · CPC title

• G01N2030/385

  by switching valves · CPC title

• G01N2030/207

  with metering cavity, e.g. sample loop · CPC title

• G01N30/38

  Flow patterns · CPC title