Preprocessing apparatus and analysis system comprising the preprocessing apparatus

Patent metadata

Field	Value
Publication number	US-11385206-B2
Application number	US-202017009302-A
Country	US
Kind code	B2
Filing date	Sep 1, 2020
Priority date	Mar 3, 2017
Publication date	Jul 12, 2022
Grant date	Jul 12, 2022

Abstract

Disclosed herein is a preprocessing apparatus that makes it possible to highly efficiently analyze specimens held by solid media, such as dried blood spots to be used for newborn mass screening or the like. The preprocessing apparatus includes: a preprocessing container setting part in which a preprocessing container containing a solid sample including a specimen to be analyzed and a solid medium holding the specimen is to be set; a carrying mechanism that carries the preprocessing container set in the preprocessing container setting part; and a preprocessing part that has a port for setting the preprocessing container carried by the carrying mechanism and that is configured to perform preprocessing including extraction processing for extracting the specimen from the solid sample contained in the preprocessing container set in the port.

First claim

What is claimed is:

1. A method for preprocessing of specimens using preprocessing containers before analyzing, wherein the method comprising the following steps of:
a specimen preparing step for preparing specimens in a liquid state or in a state contained in a solid medium,
a setting step, for setting in a state where a specimen can be dispensed into the preprocessing container when it is determined a specimen is in the liquid state, and for setting in a state where the solid medium holding a specimen is contained in the preprocessing container when it is determined the specimen is contained in the solid medium;
an information registration step for causing an analyst to register information regarding whether a specimen to be analyzed is in the liquid state or is contained in the solid medium;
a specimen recognition step for recognizing whether a specimen to be analyzed is in the liquid state or is contained in the solid medium on the basis of the information registered by the analyst;
a dispensing step for dispensing, when it is determined the specimen to be analyzed is in the liquid state, the specimen into the preprocessing container which is empty;
an extraction step for performing an extraction processing for extracting, when it is determined the specimen to be analyzed is contained in the solid medium, the specimen from the solid medium into the preprocessing container, which has been containing the solid medium; and
a preprocessing step for performing predetermined preprocessing operation to the specimen dispensed into the preprocessing container by the dispensing step or to the specimen extracted into the preprocessing container by the extraction step;
an extraction port preparing step for preparing a plurality of extraction ports for performing the extraction processing;
a searching step for searching, after the specimen recognition step, when it is determined the specimen to be analyzed is contained in the solid medium, an available extraction port for performing the extraction processing,
wherein in the extraction step, the extraction processing is performed at the available extraction port searched by the searching step; and
when it is determined there are a plurality of specimens which are contained in the solid mediums, the extraction processing of each specimen is performed in parallel using the available extraction port different from each other.

2. The method according to claim 1 , wherein
in the information registration step, causing the analyst to register information about a position where the preprocessing container containing a solid medium holding a specimen when it is determined the specimen is contained in the solid medium,
wherein the method further comprising
a preprocessing container identification step for identifying the preprocessing container containing the solid medium holding the specimen to be analyzed on a basis of the information registered by the analyst; and
a carrying step for carrying the preprocessing container identified by the preprocessing container identification step to the available extraction port,

wherein the extraction step is performed after the carrying step.

3. The method according to claim 1 , wherein the method is further comprising a transferring step for transferring the preprocessing container containing a specimen to be analyzed to a liquid chromatographic system after the preprocessing step.

Assignees

• Shimadzu Corp

Inventors

• Hanafusa Nobuhiro

Classifications

• G01N2001/288

  Filter punches · CPC title

• G01N35/00584

  Control arrangements for automatic analysers · CPC title

• G01N1/405

  by adsorption or absorption · CPC title

• B01L2300/0681

  Filter · CPC title

• G01N2035/00524

  Mixing by agitating sample carrier · CPC title