Sample testing device, sample analyzer and sample testing method

Patent metadata

Field	Value
Publication number	US-11383232-B2
Application number	US-202016801069-A
Country	US
Kind code	B2
Filing date	Feb 25, 2020
Priority date	Aug 31, 2017
Publication date	Jul 12, 2022
Grant date	Jul 12, 2022

Abstract

A sample testing device, a sample testing method, and a sample analyze are provided. The sample testing device includes a pipeline assembly, a testing assembly, and a reaction assembly. The pipeline assembly includes a first pipeline and a second pipeline. The testing assembly includes a sample needle which includes a first connection point. The reaction assembly includes a first reaction cell group connected to a second connection point of the first pipeline and a second reaction cell group which communicates with the second pipeline, and the reaction assembly is configured to treat a biological sample to prepare a test liquid. A test liquid in the first reaction cell group flows to the first connection point via the second connection point of the first pipeline, and a test liquid in the second reaction cell group flows to the first connection point via the second pipeline.

First claim

What is claimed is:

1. A sample testing device, comprising:
a pipeline assembly which comprises a first pipeline and a second pipeline;
a testing assembly which comprises a sample needle, wherein the sample needle comprises a first connection point; and
a reaction assembly which comprises a first reaction cell group and a second reaction cell group, wherein the first reaction cell group is connected to a second connection point of the first pipeline, and the second reaction cell group communicates with the second pipeline, and the reaction assembly is configured to treat a biological sample to prepare a test liquid;
wherein a test liquid in the first reaction cell group flows to the first connection point of the sample needle via the second connection point of the first pipeline, and a test liquid in the second reaction cell group flows to the first connection point of the sample needle via the second pipeline, such that the test liquid in the first reaction cell group or in the second reaction cell group respectively flows into the sample needle of the testing assembly for detecting,
wherein the sample testing device further comprises a sample injecting assembly, the sample injecting assembly is respectively connected to a third connection point of the first pipeline and a fourth connection point of the second pipeline, the third connection point is located between the second connection point and the first connection point, a channel between the third connection point and the first connection point is configured as a first test liquid preparation section, and a channel between the fourth connection point and the first connection point is configured as a second test liquid preparation section,
wherein the test liquid in the first reaction cell group flows to the third connection point of the first pipeline via the second connection point of the first pipeline, and flows into the first test liquid preparation section via the third connection point of the first pipeline, wherein the test liquid in the second reaction cell group flows to the fourth connection point of the second pipeline via the second pipeline, and flows into the second test liquid preparation section via the fourth connection point of the second pipeline,
wherein the sample injecting assembly is configured to inject the test liquid in the first test liquid preparation section or in the second test liquid preparation section into the sample needle of the testing assembly,
wherein an end of the second pipeline away from the second reaction cell group is connected to a tenth connection point of the first pipeline, and the tenth connection point and the second connection point are respectively located on opposite sides of the first connection point, and
wherein a three-way joint is provided on the first pipeline for communicating the tenth connection point and the second connection point with the first connection point of the sample needle.

2. The sample testing device of claim 1 , wherein the sample testing device further comprises a sample drawing assembly, the sample drawing assembly is connected to an end of the first pipeline or the end of the second pipeline, and the sample drawing assembly is configured to generate a negative pressure to correspondingly draw the test liquid in the first reaction cell group into the first test liquid preparation section, or draw the test liquid in the second reaction cell group into the second test liquid preparation section.

3. The sample testing device of claim 2 , wherein the sample drawing assembly comprises a second waste liquid cell and a seventh switching member; a negative pressure is generated in the second waste liquid cell, and the seventh switching member is connected between the second waste liquid cell and an end of the first pipeline, the end of the second pipeline or an end of a third pipeline, and the seventh switching member is configured to implement cutting-off and connecting.

4. The sample testing device of claim 1 , wherein the sample testing device further comprises a first cleaning assembly and a second cleaning assembly, the first cleaning assembly is connected to the first pipeline, and a cleaning fluid in the first cleaning assembly flows into the first pipeline to clean the first pipeline, and
wherein the second cleaning assembly is connected to the second pipeline, and a cleaning fluid in the second cleaning assembly flows into the second pipeline to clean the second pipeline.

5. The sample testing device of claim 1 , wherein the sample testing device comprises a third cleaning assembly, the first pipeline and the second pipeline are commonly connected to the third cleaning assembly, and a cleaning fluid in the third cleaning assembly flows into the first pipeline or the second pipeline to clean the first pipeline or the second pipeline.

6. The sample testing device of claim 5 , wherein the second reaction cell group is further connected to a fifth connection point of the first pipeline, and the third cleaning assembly is connected to an end of the first pipeline,
wherein the cleaning fluid in the third cleaning assembly flows into the first pipeline from the end of the first pipeline to clean the first pipeline, or the cleaning fluid in the third cleaning assembly flows from the end of the first pipeline to the fifth connection point of the first pipeline, and flows from the fifth connection point into the connection point of the second reaction cell group in the second pipeline to clean the second pipeline.

7. The sample testing device of claim 1 , wherein the reaction assembly further comprises a third reaction cell group, the third reaction cell group is connected to a sixth connection point of the first pipeline, and a test liquid in the third reaction cell group flows to the first connection point of the sample needle via the sixth connection point of the first pipeline, so that the test liquid in the third reaction cell group flows into the sample needle of the testing assembly for detecting,
wherein the test liquid in the first reaction cell group or the third reaction cell group respectively flows to the third connection point of the first pipeline via the second connection point of the first pipeline or the sixth connection point of the first pipeline, and flows into the first test liquid preparation section via the third connection point of the first pipeline, or the test liquid in the second reaction cell group flows to the fourth connection point of the second pipeline via the second pipeline, and flows into the second test liquid preparation section via the fourth connection point of the second pipeline.

8. The sample testing device of claim 1 , wherein the sample injecting assembly comprises an injector, a selection switching member disposed at an injection port of the injector, a fourth branch and a fifth branch; one end of the fourth branch and one end of the fifth branch are respectively connected to the third connection point and the fourth connection point, another end of the fourth branch and another end of the fifth branch are commonly disposed at the selection switching member, and the selection switching member is configured to switch between the fourth branch and the fifth branch to communication with the injector.

9. The sample testing device of claim 8 , wherein the sample testing device further comprises a sample drawing assembly, the sample drawing assembly is connected to an end of the first pipeline or the end of the second pipeline, and the sample drawing assembly is configured to:
generate a negative pressure to draw the test liquid in the first reaction cell group or in the third reaction cell group into the first test liquid preparation section; or
generate a negative pressur

Assignees

• Shenzhen Mindray Biomedical Electronics Co Ltd

Inventors

• Liu Yinming
• Teng Jin
• Shi Huilin

Classifications

• B01L2200/0621

  Control of the sequence of chambers filled or emptied · CPC title

• G01N33/49 Primary

  Blood {(chemical methods for determining blood cell populations G01N33/5094; chemical analysis of blood groups or blood types G01N33/80)} · CPC title

• G01N15/1404

  Handling flow, e.g. hydrodynamic focusing · CPC title

• B01L3/502 Primary

  with fluid transport, e.g. in multi-compartment structures · CPC title

• G01N1/14

  Suction devices, e.g. pumps; Ejector devices · CPC title