Method for creating a mineral trioxide aggregate material with improved biological effects

Patent metadata

Field	Value
Publication number	US-11382840-B2
Application number	US-202017113380-A
Country	US
Kind code	B2
Filing date	Dec 7, 2020
Priority date	Apr 29, 2015
Publication date	Jul 12, 2022
Grant date	Jul 12, 2022

Abstract

A dental device is improved in its ability to produce hydroxyl apatite by having a layer of mineral trioxide aggregate (MTA) deposited thereon. A tile of MTA is prepared, heat treated and sintered to produce a micronized tile of MTA that can then be deposited by physical vapor depositions, hot isostatic pressing, molding or other conventional technique.

First claim

The invention claimed is:

1. An implantable dental device comprising a bio-functional coating of a mineral trioxide aggregate (MTA) material derived from a dense mineral trioxide aggregate (MTA) target; wherein the bio-functional coating of MTA is derived from the dense MTA target by processing of the dense MTA target: wherein the processing of the dense MTA target includes a physical vapor deposition process.

2. The implantable dental device according to claim 1 , wherein said device is selected from gutta percha points and titanium implantable device.

3. The implantable dental device according to 2 , wherein the thickness of the bio-functional coating on the gutta percha points is from 338 nm to 522 nm.

4. The implantable dental device according to claim 2 , wherein the thickness of the bio-functional coating on the titanium implantable device is from 50 nm to 1079 nm.

5. The implantable dental device according to claim 1 , wherein the dense MTA target is selected from a sintered MTA target or a hot isostatic pressing (HIP)-sintered MTA target.

6. The implantable dental device according to claim 5 , wherein the sintered MTA target is produced by a process; said process comprising:
(i) mixing portland cement with deionized water having a ratio in the range of about 10:1 to about 1:10 to create a mixed cement;
(ii) curing the mixed cement in a mold to obtain a cured cement;
(iii) heating the cured cement in a post cure bake oven at a temperature from about 50° C. to about 500° C. to produce a post cure baked cement;
(iv) micronizing the post cure baked cement to a particle size ranging from about 1 micron to about 200 micron to form a micronized MTA;
(v) pressing the micronized MTA into a green compact using a hydraulic press with an applied pressure range from 60 Psi to 120 Psi;
(vi) heating the green compact in a sintering chamber to produce the sintered MTA target.

7. The implantable dental device according to claim 6 , further comprising heating the sintered MTA target in a hot isostatic pressing (HIP) chamber at a temperature from about 25° C. to about 1500° C. to obtain the hot isostatic pressing (HIP)-sintered MTA target.

8. The implantable dental device according to claim 1 , wherein the physical vapor deposition process includes one of cathodic arc deposition, electron beam physical vapor deposition, evaporative deposition, pulsed laser deposition or sputter deposition.

9. An implantable dental device comprising a bio-functional coating of a mineral trioxide aggregate (MTA) material derived from a dense mineral trioxide aggregate (MTA) target; wherein the bio-functional coating of MTA is derived from the dense MTA target by processing of the dense MTA target, wherein the processing of the dense MTA target includes (a) micronizing the dense MTA target to a particle size ranging from about 1 micron to about 200 microns to obtain a micronized dense MTA target; and (b) coating of micronized dense MTA target on a surface of dental device by compression molding, injection molding or powder spraying; wherein said device is selected from gutta percha points and titanium implantable device.

10. A method of forming a bio-functional coating of MTA material on a dental device, said method comprising:
(a) providing a dense MTA target; and
(b) processing of the dense MTA target to form the bio-functional coating of MTA material on a surface of dental device; wherein the processing of the dense MTA target includes a physical vapor deposition process.

11. The method according to claim 10 , wherein the physical vapor deposition process includes one of cathodic arc deposition, electron beam physical vapor deposition, evaporative deposition, pulsed laser deposition or sputter deposition.

12. The method according to claim 10 , wherein the dense MTA target is selected from sintered MTA target or hot isostatic pressing (HIP)-sintered MTA target.

13. The method according to claim 12 , wherein the sintered MTA target is produced by process comprising:
(i) mixing portland cement with deionized water having a ratio in the range of about 10:1 to about 1:10 to create a mixed cement;
(ii) curing the mixed cement in a mold to obtain a cured cement;
(iii) placing the cured cement in a post cure bake oven at a temperature from about 50° C. to about 500° C. to produce a post cure baked cement;
(iv) micronizing the post cure baked cement to a particle size ranging from about 1 micron to about 200 micron to form a micronized MTA;
(v) pressing the micronized MTA into a green compact using a hydraulic press with an applied pressure range from 60 Psi to 120 Psi; and heating the green compact in a sintering chamber to produce the sintered MTA target.

14. The method according to claim 13 , further comprising placing the sintered MTA target in a hot isostatic pressing (HIP) chamber at a temperature from about 250° C. to about 1500° C. to obtain hot isostatic pressing (HIP)-sintered MTA target.

15. A method of forming a bio-functional coating of MTA material on a dental device, said method comprising:
(a) providing a dense MTA target: and
(b) processing of the dense MTA target to form the bio-functional coating of MTA material on a surface of dental device; wherein the processing of the dense MTA target includes (i) micronizing the dense MTA target to a particle size ranging from about 1 micron to about 200 microns to obtain a micronized dense MTA target; and (ii) coating of micronized dense MTA target on a surface of dental device by compression molding, injection molding or powder spraying; wherein said device is selected from gutta percha points and titanium implantable device.

Assignees

• Dentsply Sirona Inc

Inventors

• Wilkinson Kevin
• Ndungu Geoffrey

Classifications

• A61K6/887

  Compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds · CPC title

• C23C14/24

  Vacuum evaporation · CPC title

• A61C8/0013

  with a surface layer, coating · CPC title

• A61K6/76

  comprising silicon-containing compounds · CPC title

• A61L27/306

  Other specific inorganic materials not covered by A61L27/303 - A61L27/32 · CPC title