Chromatographic separation of Mo-99 from W-187

Patent metadata

Field	Value
Publication number	US-11380453-B2
Application number	US-201716325245-A
Country	US
Kind code	B2
Filing date	Aug 14, 2017
Priority date	Aug 16, 2016
Publication date	Jul 5, 2022
Grant date	Jul 5, 2022

Abstract

The present disclosure provides a method of separating Mo-99 from W-187 from a solution comprising Mo-99 and W-187. The method comprises contacting a tridentate diglycolanude ligand with a solution comprising Mo-99 and W-187 and eluting W-187 from the tridentate diglycolanude ligand to thereby an eluate comprising W-187.

First claim

What is claimed is:

1. A method of separating Mo-99 from W-187 from a solution comprising Mo-99 and W-187, the method comprising:
contacting a tridentate diglycolamide ligand with a solution comprising Mo-99 and W-187; and
eluting the W-187 from the tridentate diglycolamide ligand to thereby yield an eluate comprising W-187.

2. The method of claim 1 wherein the tridentate diglycolamide ligand comprises N,N,N′,N′-tetraoctyldiglycolamide.

3. The method of claim 1 wherein the Mo-99 is in a molybdate salt.

4. The method of claim 1 wherein the W-187 is in a tungstate salt.

5. The method of claim 1 wherein the tridentate diglycolamide ligand is contacted with the solution comprising Mo-99 and W-187 in a chromatography column.

6. The method of claim 1 wherein the tridentate diglycolamide ligand is contacted with the solution comprising Mo-99 and W-187 in a chromatography cartridge.

7. The method of claim 1 wherein the solution comprising Mo-99 and W-187 further comprises an acid.

8. The method of claim 1 wherein the solution comprising Mo-99 and W-187 further comprises an acid in a concentration of at least about 2.0 M.

9. The method of claim 1 wherein the solution comprising Mo-99 and W-187 further comprises an acid selected from the group consisting of hydrochloric acid, nitric acid, sulfuric acid, and any combination thereof.

10. The method of claim 1 wherein the solution comprises W-187/Mo-99 in an activity ratio of between about 500 kBq and about 18 KBq W-187 activity to about 370 MBq of Mo-99 activity.

11. The method of claim 1 wherein at least about 99% of Mo-99 is removed from the solution.

12. The method of claim 1 wherein the yield of W-187 is at least about 80%, or at least about 85%, or at least about 90%, or between about 90% and about 95%.

13. The method of claim 1 further comprising eluting the Mo-99 from the tridentate diglycolamide ligand by contact with an alkaline solution.

14. The method of claim 1 wherein the solution comprising Mo-99 and W-187 further comprises an acid in a concentration of at least about 2.5 M.

15. The method of claim 1 wherein the solution comprising Mo-99 and W-187 further comprises an acid in a concentration of at least about 3.0 M.

16. The method of claim 1 wherein the solution comprising Mo-99 and W-187 further comprises an acid in a concentration of at least about 3.5 M.

17. The method of claim 1 wherein at least about 99.5% of Mo-99 is removed from the solution.

18. The method of claim 1 wherein at least about 99.9% of Mo-99 is removed from the solution.

19. The method of claim 1 wherein at least about 99.99% of Mo-99 is removed from the solution.

Assignees

• Curium Us Llc

Inventors

• Booij Arend

Classifications

• G21G1/001 Primary

  Recovery of specific isotopes from irradiated targets · CPC title

• G21G2001/0094

  Other isotopes not provided for in the groups listed above · CPC title

• B01D15/3828

  Ligand exchange chromatography, e.g. complexation, chelation or metal interaction chromatography · CPC title

• C22B3/24

  by adsorption on solid substances, e.g. by extraction with solid resins · CPC title

• G21G2001/0036

  Molybdenum · CPC title