Dispensing robot, method of controlling dispensing robot, and dispensing method

Patent metadata

Field	Value
Publication number	US-11372012-B2
Application number	US-201816228946-A
Country	US
Kind code	B2
Filing date	Dec 21, 2018
Priority date	Dec 26, 2017
Publication date	Jun 28, 2022
Grant date	Jun 28, 2022

Abstract

A dispensing robot of an assay robot system includes a first contact surface oriented in a downward direction or an obliquely downward direction in a vertical direction and dispenses when the dispensing robot operates a pipette that allows a tip to be attached to a lower end of the pipette and the attached tip to be detached by pressing a tip ejector, the dispensing robot comprising: a robot arm having a hand to hold a pipette holding piece attached thereto; and a controller controls the robot arm such that the robot arm holds the pipette with the tip attached thereto by causing the hand to hold the pipette holding piece and that the robot arm is elevated and the tip ejector is pressed by bringing an upper end portion of the tip ejector of the held pipette into contact with the first contact surface from the downward direction.

First claim

The invention claimed is:

1. An assay robot system comprising:
a first contact member having a first contact surface facing a downward vertical direction or an obliquely downward vertical direction;
a dispensing robot configured to operate a pipette to attach a tip to a lower end of the pipette and to operate the pipette to detach the attached tip from the lower end of the pipette by pressing a tip ejector;
a second contact member having a second contact surface;
a tip detachment detector that detects whether the tip has been detached from the pipette; and
a controller configured to control operation of the dispensing robot such that:
the dispensing robot holds the pipette with the tip attached thereto;
the dispensing robot elevates the pipette such that the tip ejector is pressed by bringing an upper end portion of the tip ejector into contact with the first contact surface of the first contact member; and
the dispensing robot moves the pipette horizontally toward the second contact member so as to detach the tip by contacting with, by the horizontal movement, the second contact surface of the second contact member in response to the tip detachment detector detecting that the tip is undetached from the pipette after the tip ejector has been pressed.

2. The assay robot system according to claim 1 , wherein :
the second contact surface extends in a shape of an arc; and
the controller controls the dispensing robot such that, when controlling the dispensing robot such that the dispensing robot brings the distal end portion of the tip into contact with the second contact surface, the dispensing robot brings the distal end portion of the tip into contact with the second contact surface in a middle of the second contact surface.

3. The assay robot system according to claim 1 , wherein
the dispensing robot comprises a pipette holding piece comprising a holder formed of partially cylindrical members, and
circumferential end surfaces of the partially cylindrical members are arranged to face each other such that the partially cylindrical members form a cylindrical shape as a whole, and an internal space with an inner peripheral shape corresponding to an outer peripheral shape of a predetermined portion of a grip portion of the pipette.

4. A method of controlling an assay robot system, the method comprising:
controlling a dispensing robot to hold a pipette with a tip attached thereto;
controlling the dispensing robot to elevate the pipette such that a tip ejector is pressed by bringing an upper end portion of the tip ejector into contact with a first contact member having a first contact surface facing a downward vertical direction or an obliquely downward vertical direction;
detecting whether the tip has been detached from the pipette after the tip ejector has been pressed; and
controlling the dispensing robot to move the pipette horizontally toward a second contact member having a second contact surface so as to detach the tip by contacting with, by the horizontal movement, the second surface of the second contact member in response to detecting that the tip is undetached from the pipette after the tip ejector has been pressed.

5. The method of controlling the assay robot system according to claim 4 , further comprising:
causing the controller to control the dispensing robot comprising causing the controller to control the dispensing robot such that, when controlling the dispensing robot such that the dispensing robot brings the distal end portion of the tip into contact with the second contact surface extending in a shape of an arc, the dispensing robot brings the distal end portion of the tip into contact with the second contact surface in a middle of the second contact surface.

6. The method of controlling the assay robot system according to claim 4 , wherein
the dispensing robot comprises a pipette holding piece comprising a holder formed of partially cylindrical members, and
circumferential end surfaces of the partially cylindrical members are arranged to face each other such that the partially cylindrical members form a cylindrical shape as a whole, and an internal space with an inner peripheral shape corresponding to an outer peripheral shape of a predetermined portion of a grip portion of the pipette.

7. A dispensing method carried out by the assay robot system according to claim 1 comprising:
holding a pipette holding piece attached to the pipette with a hand of a robot arm of the dispensing robot;
attaching the tip to the pipette by moving the pipette so as to insert the pipette to the tip;
dispensing liquid using the pipette to which the tip is attached; and
detaching the tip used for dispensing the liquid from the pipette by moving the pipette so as to bring the tip ejector of the held pipette into contact with the first contact member.

8. The dispensing method according to claim 7 , the method further comprising:
detecting, using the tip detachment detector, whether the tip has been detached from the pipette after the tip ejector is contacted with the first contact member; and
in response to the tip detachment detector detecting that the tip is undetached from the pipette after the tip ejector has been contacted with the first contact member, using the dispensing robot to move the pipette horizontally toward the second contact member so as to detach the tip by contacting the tip, by the horizontal movement, with the second contact surface of the second contact member.

Assignees

• Kawasaki Heavy Ind Ltd
• Sysmex Corp

Inventors

• Iwasaki Yukio
• Ouchi Satoshi
• Mitsui Eiji
• Matsuoka Junichi
• Kirimura Hiroya
• Kitano Yukihiko

Classifications

• B01L2300/0654

  Lenses; Optical fibres · CPC title

• G01N35/1065

  Multiple transfer devices · CPC title

• G01N2035/103

  using disposable tips · CPC title

• B01L2200/143

  Quality control, feedback systems · CPC title

• G01N35/0099 Primary

  comprising robots or similar manipulators (robots per se B25J) · CPC title