Multilayer polymer composite constructs

Patent metadata

Field	Value
Publication number	US-11364656-B2
Application number	US-201916503848-A
Country	US
Kind code	B2
Filing date	Jul 5, 2019
Priority date	Jul 5, 2018
Publication date	Jun 21, 2022
Grant date	Jun 21, 2022

Abstract

A method of forming particles for controlled guest agent release includes coextruding first and second polymer materials to form a multilayer polymer composite sheet comprising alternating first and second polymer layers, dividing the multilayer sheet into particles, immersing the particles in a solvent containing the guest agent such that the first layers swell and the guest agent is loaded into the swollen first layers.

First claim

We claim:

1. A method of forming particles for controlled guest agent release, comprising:
coextruding first and second polymer materials to form a multilayer polymer composite sheet comprising alternating first and second polymer layers, the first and second polymer layers being substantially immiscible;
dividing the multilayer sheet into particles; and
immersing the particles in a solvent containing the guest agent such that the first polymer layers swell and the second polymer layers are resistant to swelling in the solvent;
wherein during immersion of the particles, the guest agent diffuses into and/or is loaded into the swollen first polymer layers.

2. The method of claim 1 , further comprising drying the swollen first polymer layers such that the swollen first polymer layers reduce in size.

3. The method of claim 1 , the step of dividing the multilayer sheet comprises cutting the multilayer sheet into microparticles and/or nanoparticles.

4. The method of claim 3 , the microparticles and/or nanoparticles having a size of about 50 nm to about 500 μm wide×about 50 nm to about 500 μm long×about 100 nm to about 150 μm thick.

5. The method of claim 1 , wherein the guest agent comprises a thermally unstable therapeutic agent.

6. The method of claim 1 , the first polymer material being polyethylene oxide (PEO) and the second polymer material being polycaprolactone (PCL).

7. The method of claim 1 , the solvent including NaCl and ethanol.

8. The method of claim 1 , further comprising coextruding a skin layer with the first and second polymer layers.

9. The method of claim 8 , the skin layer comprising polyethylene (PE).

10. A method of forming a plurality of microparticles and/or nanoparticles for controlled release of a thermally unstable guest agent comprising:
coextruding first and second polymer materials to form a multilayer polymer composite sheet comprising alternating first and second polymer layers, the first and second polymer layers being substantially immiscible;
mechanically cutting the multilayer sheet into particles; and
immersing the particles in a solvent containing the guest agent such that the first polymer layers swell and the second polymer layers are resistant to swelling in the solvent;
wherein during immersion of the particles, the guest agent diffuses into and/or is loaded into the swollen first polymer layers.

11. The method of claim 10 , further comprising drying the swollen first polymer layers such that the swollen first polymer layers reduce in size.

12. The method of claim 10 , the step of cutting the multilayer sheet comprises cutting the multilayer sheet into microparticles and/or nanoparticles.

13. The method of claim 12 , the microparticles having a size of about 50 nm to about 500 μm wide×about 50 nm to about 500 μm long×about 100 nm to about 150 μm thick.

14. The method of claim 10 , wherein the guest agent comprises a thermally unstable therapeutic agent.

15. The method of claim 10 , the first polymer material being polyethylene oxide (PEO) and the second polymer material being polycaprolactone (PCL).

16. The method of claim 10 , the solvent including NaCl and ethanol.

17. The method of claim 10 , further comprising coextruding a skin layer with the first and second polymer layers.

18. The method of claim 17 , the skin layer comprising polyethylene (PE).

Assignees

• Univ Case Western Reserve

Inventors

• Advincula Rigoberto
• Chao Pengfei
• Baer Eric

Classifications

• B32B27/281

  comprising polyimides · CPC title

• B29B9/16

  Auxiliary treatment of granules · CPC title

• B32B2307/73

  Hydrophobic · CPC title

• B32B2250/03

  3 layers · CPC title

• B32B23/04

  comprising such {cellulosic plastic} substance as the main or only constituent of a layer, {which is} next to another layer of {the same or of} a {different material (next to a glass layer B32B17/08)} · CPC title