Biological information analysis device, system, and program

Patent metadata

Field	Value
Publication number	US-11363961-B2
Application number	US-201716092151-A
Country	US
Kind code	B2
Filing date	Apr 14, 2017
Priority date	Apr 15, 2016
Publication date	Jun 21, 2022
Grant date	Jun 21, 2022

Abstract

A biological information analysis device including: an indicator extraction unit configured to extract an indicator indicating a cardiac state, from data regarding blood pressure waveforms that are consecutively measured by a sensor that is configured to be worn on a body part of a user and to be capable of non-invasively measuring a blood pressure waveform for each heartbeat; and a processing unit configured to output the indicator extracted by the indicator extraction unit. The indicator extraction unit is configured to extract a value of a cardiac load indicator for each heartbeat, from the data regarding blood pressure waveforms, and calculate the indicator indicating the cardiac state, based on characteristics related to distribution of values of the cardiac load indicator corresponding to a plurality of heartbeats.

First claim

The invention claimed is:

1. A biological information analysis device comprising at least one memory and at least one processor which function as:
an indicator extraction unit configured to extract an indicator indicating a cardiac state, from data regarding blood pressure waveforms that are consecutively measured by a sensor that is configured to be wearable on a body part of a user and capable of non-invasively measuring a blood pressure waveform for each heartbeat; and
a processing unit configured to output the indicator extracted by the indicator extraction unit,
wherein the indicator extraction unit is configured to extract a value of a cardiac load indicator for each heartbeat, from the data regarding blood pressure waveforms,
wherein the indicator indicating the cardiac state is determined based on at least one of:
a frequency with which a stroke volume exceeds a first threshold value in a distribution of the value of the cardiac load indicator determined based on a stroke volume for each heartbeat wherein a state in which an instantaneous stroke volume is greater than the first threshold value is a state in which excessive preload has occurred, and the first threshold value is determined based on the maximum value of the instantaneous stroke volume of the user,
a frequency with which the stroke volume falls below a second threshold value in the distribution of the value of the cardiac load indicator determined based on the stroke volume for each heartbeat wherein a state in which the instantaneous stroke volume is smaller than the second threshold value is a state in which preload is excessively low, and the second threshold value is determined based on the lower limit of a typical reference value of the stroke volume, and
a frequency with which a total peripheral resistance exceeds a third threshold value in the distribution of the value of the cardiac load indicator determined based on the total peripheral resistance for each heartbeat wherein a state in which an instantaneous total peripheral resistance is greater than the third threshold value is a state in which excessive afterload has occurred, and the third threshold value is determined based on the upper limit of a typical reference value of the total peripheral resistance.

2. The biological information analysis device according to claim 1 , wherein the indicator indicating the cardiac state is determined based on the maximum value of the stroke volume in the distribution.

3. The biological information analysis device according to claim 1 , wherein the processing unit is configured to output temporal changes in values of the cardiac load indicator corresponding to a plurality of heartbeats, and the indicator indicating the cardiac state.

4. The biological information analysis device according to claim 3 , wherein the processing unit is configured to acquire, from a second sensor, data indicating at least one of the user's body movement and the state of the environment during measurement of blood pressure waveforms, and output temporal changes in the cardiac load indicator in association with at least one of the user's body movement and the state of the environment.

5. The biological information analysis device according to claim 3 , wherein the processing unit is configured to acquire, from a second sensor, time-series data indicating the state of the environment during measurement of blood pressure waveforms, and output the cardiac load indicator and the state of the environment in association with each other.

6. A system comprising:
a sensor that is configured to be worn on a body part of a user and capable of non-invasively measuring a blood pressure waveform for each heartbeat; and
the biological information analysis device according to claim 1 , the biological information analysis device being configured to analyze biological information, using data regarding blood pressure waveforms consecutively measured by the sensor.

7. A non-transitory computer-readable medium storing a program that causes a processor to function as the indicator extraction unit and the processing unit of the biological information analysis device according to claim 1 .

8. A biological information analysis method comprising:
a step of acquiring, by at least one processor, data regarding blood pressure waveforms that are consecutively measured by a sensor that is configured to be wearable on a body part of a user and capable of non-invasively measuring a blood pressure waveform for each heartbeat;
a step of extracting, by the at least one processor, a value of a cardiac load indicator for each heartbeat, from the data regarding blood pressure waveforms; and
a step of outputting, by the at least one processor, an indicator indicating a cardiac state,
wherein the indicator indicating the cardiac state is determined based on at least one of:
a frequency with which a stroke volume exceeds a first threshold value in a distribution of the value of the cardiac load indicator determined based on the stroke volume for each heartbeat wherein a state in which an instantaneous stroke volume is greater than the first threshold value is a state in which excessive preload has occurred, and the first threshold value is determined based on the maximum value of the instantaneous stroke volume of the user,
a frequency with which the stroke volume falls below a second threshold value in the distribution of the value of the cardiac load indicator determined based on the stroke volume for each heartbeat wherein a state in which the instantaneous stroke volume is smaller than the second threshold value is a state in which preload is excessively low, and the second threshold value is determined based on the lower limit of a typical reference value of the stroke volume, and
a frequency with which a total peripheral resistance exceeds a third threshold value in the distribution of the value of the cardiac load indicator determined based on the total peripheral resistance for each heartbeat wherein a state in which an instantaneous total peripheral resistance is greater than the third threshold value is a state in which excessive afterload has occurred, and the third threshold value is determined based on the upper limit of a typical reference value of the total peripheral resistance.

Assignees

• Omron Tateisi Electronics Co
• Omron Healthcare Co Ltd

Inventors

• Nakajima Hiroshi
• Wada Hirotaka
• Tsuchiya Naoki
• Kasai Masaaki
• Kan Eriko
• UENOYAMA Toru
• OBAYASHI Keiichi
• KOKUBO Ayako
• Ota Yuya
• Shiga Toshikazu
• Kuwabara Mitsuo
• Sato Hironori
• Miyagawa Ken
• Tsutsumi Masakazu

Classifications

• A61B5/7221

  Determining signal validity, reliability or quality (preventing, reducing or removing noise induced by motion artefacts A61B5/7207; noise originating from a therapeutic or surgical apparatus A61B5/7217) · CPC title

• A61B5/14542

  for measuring blood gases (A61B5/14551 takes precedence) · CPC title

• A61B5/7257

  using Fourier transforms · CPC title

• A61B2560/0242

  adapted to measure environmental factors, e.g. temperature, pollution · CPC title

• A61B5/4818

  Sleep apnoea · CPC title