Compounding device, system, kit, software, and method

Patent metadata

Field	Value
Publication number	US-11357966-B2
Application number	US-201514693867-A
Country	US
Kind code	B2
Filing date	Apr 23, 2015
Priority date	Apr 23, 2015
Publication date	Jun 14, 2022
Grant date	Jun 14, 2022

Abstract

An exemplary compounding system and method can include two pump heads for simultaneously drawing two different fluids from at least two separate input containers such that the at least two different fluids are mixed and distributed to an output container. The system can include a manifold that maintains separation of certain of the different fluids until after passing by a first pump and a second pump and/or additional pumps. A junction can be placed in the fluid line downstream of the first and second pumps and/or additional pumps such that all or some of the fluids are mixed prior to output to the output container. The method of using the system can include incorporating software that selects various fluids at certain times and sequences to ensure optimum efficiency and safety for the system, and can continue compounding actions even when an input supply container runs out or otherwise fails to supply a particular fluid/material. The method of use also includes connection of a transfer set to a housing in a manner that further ensures optimum efficiency and safety.

First claim

What is claimed is:

1. A compounding device for transferring materials from at least two distinct material sources to a final container, comprising:
a housing, the housing defining a valve surface and a pump surface;
at least one rotatable micro valve actuation device adjacent the valve surface;
at least one rotatable macro valve actuation device adjacent the valve surface;
a micro pump located adjacent the pump surface on the housing; and
a macro pump located adjacent the pump surface on the housing, wherein the rotatable micro valve actuation device operates to rotate in one of a clockwise direction, a counterclockwise direction, and a combination of clockwise direction and counterclockwise direction, and in coordination with the micro pump to convey material from at least one of the material sources to the final container, and the rotatable macro valve actuation device operates to rotate in one of a clockwise direction, a counterclockwise direction, and a combination of clockwise direction and counterclockwise direction, and in coordination with the macro pump to convey materials from at least another one of the material sources to the final container.

2. The compounding device of claim 1 , further comprising:
a sensor bridge located on the housing and between the valve surface and the pump surface such that the micro pump and macro pump are separated from the rotatable micro valve actuation device and rotatable macro valve actuation device by the sensor bridge, the sensor bridge including a first throughway configured to house a micro input line, and a second throughway configured to house a macro input line.

3. The compounding device of claim 2 , wherein the first throughway has a cross-section taken normal to a fluid pathway through the first throughway that is smaller than a cross-section of the second throughway taken normal to a fluid pathway through the second throughway.

4. The compounding device of claim 2 , wherein the sensor bridge includes at least one bubble detection sensor configured to detect air bubbles located in material in at least one of the first throughway and second throughway.

5. The compounding device of claim 2 , wherein the sensor bridge includes at least one occlusion detection sensor configured to detect an occlusion occurring in at least one of the first throughway and second throughway.

6. The compounding device of claim 1 , wherein the micro pump includes a first rotor located adjacent a first platen, and the macro pump includes a second rotor located adjacent a second platen.

7. The compounding device of claim 6 , wherein the first rotor and second rotor are interchangeable with each other.

8. The compounding device of claim 1 , wherein the at least one rotatable micro valve actuation device includes a plurality of rotatable micro valve actuation devices, and the at least one rotatable macro valve actuation device includes a plurality of rotatable macro valve actuation devices, and the plurality of rotatable micro valve actuation devices are configured to actuate in cooperation with actuation of the micro pump, and the plurality of rotatable macro valve actuation devices are configured to actuate in cooperation with actuation of the macro pump.

9. The compounding device of claim 8 , wherein both the rotatable macro valve actuation devices and the rotatable micro valve actuation devices are configured to simultaneously open corresponding valves during simultaneous flushing of a macro channel and a micro channel of the compounding device.

10. The compounding device of claim 1 , wherein the macro pump is configured to pump a first volume per second, and the micro pump is configured to pump a second volume per second, wherein the first volume per second is larger than the second volume per second.

11. The compounding device of claim 1 , wherein each rotatable micro valve actuation device includes a first stepper motor, and each rotatable macro valve actuation device includes a second stepper motor.

12. The compounding device of claim 1 , wherein the micro pump includes a micro pump stepper motor connected to a first rotor, and the macro pump includes a macro pump stepper motor connected to a second rotor.

13. The compounding device of claim 1 , further comprising:
a transfer set including a manifold configured for attachment to the valve surface of the housing, and a plurality of transfer lines connecting corresponding material sources to the manifold.

14. The compounding device of claim 1 , further comprising:
a manifold attached to the valve surface and having inlets for connection to the material sources, the manifold having a micro valve and a micro outlet downstream of the micro valve, and the manifold having a macro valve and a macro outlet downstream of the macro valve, wherein
the at least one rotatable micro valve actuation device is configured to actuate the micro valve,
the at least one rotatable macro valve actuation device is configured to actuate the macro valve,
the micro pump is located downstream of the micro outlet of the manifold, and
the macro pump is located downstream of the macro outlet of the manifold.

15. A method for compounding materials from a plurality of source containers into the final container using the compounding device of claim 1 , the method comprising:
providing the micro pump, the macro pump, a first material source of the material sources including a first material, a second material source of the material sources including a second material, a third material source of the material sources including a third material, the final container, and a controller;
operating the micro pump via the controller to transfer the first material from the first material source to the final container;
operating the macro pump via the controller to transfer the second material from the second material source to the final container;
operating one of the micro pump and the macro pump via the controller to transfer the third material from the third material source to the final container; and
mixing the first material, second material, and third material at a location downstream of the micro pump and the macro pump.

16. The method for compounding materials of claim 15 , further comprising:
providing a union junction located between the final container and both the micro pump and macro pump, wherein the mixing occurs at the union junction.

17. The method for compounding materials of claim 15 , wherein operating the micro pump and operating the macro pump occurs simultaneously.

18. The method for compounding materials of claim 15 , further comprising simultaneously ceasing operation of one of the micro pump and macro pump and continuing operation of the other of the micro pump and the macro pump.

19. The method for compounding materials of claim 15 , further comprising:
providing a flex line from the third material source to both the macro pump and micro pump such that the macro pump and micro pump are both in fluid communication with the third material.

20. A compounding device for transferring materials from at least two distinct material sources to a final container, comprising:
a housing, the housing defining a valve surface and a pump surface;
at least one rotatable micro valve actuation device adjacent the valve surface;
at least one rotatable macro valve actuation device adjacent the valve surface;
a micro pump located adjacent the pump surface on the housing;
a macro pump located adjacent the pump surface on the housing, wherein the rota

Assignees

• Braun Medical Inc

Inventors

• Lane Benjamin R
• Mumpower Mariano
• Cowperthwaite Jake A
• Kendall Jamie
• Savage Jeremy C
• Larrow Chet B
• Flamm Alex K
• Hershey Dave E
• Pearl Aaron S
• Brown Michael Y
• Konrad Jr Karl
• Bartholomew Joel
• Janders Mike
• Burnard Edwin

Classifications

• A61M39/22

  Valves or arrangement of valves {(A61M39/02, A61M39/0247, A61M39/16 take precedence; regulating valves in infusion systems A61M5/16881; in devices worn by the patient for the reception of urine, faeces, catamenial or other discharge, or in colostomy devices A61F5/4405)} · CPC title

• B01F2101/22

  Mixing of ingredients for pharmaceutical or medical compositions · CPC title

• B01F35/717611

  Peristaltic pumps · CPC title

• B01F33/846

  using stored recipes for determining the composition of the mixture to be produced, i.e. for determining the amounts of the basic components to be dispensed from the component receptacles · CPC title

• A61J3/00

  Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms · CPC title