Systems and methods for priming a fluid circuit

Patent metadata

Field	Value
Publication number	US-11357900-B2
Application number	US-201715600447-A
Country	US
Kind code	B2
Filing date	May 19, 2017
Priority date	May 27, 2016
Publication date	Jun 14, 2022
Grant date	Jun 14, 2022

Abstract

Methods and systems for priming a disposable fluid circuit for the processing of a biological fluid are disclosed. The methods and systems allow for variable and configurable priming of the flow path(s) leading to one or more biological fluid source containers.

First claim

The invention claimed is:

1. An automated system for the processing of biological fluid comprising:
a. a reusable hardware unit comprising at least a separation device drive unit for receiving a single separation device, a plurality of pumps, and a controller;
b. a disposable fluid circuit mountable on said reusable hardware unit, said disposable fluid circuit including tubing defining multiple flow paths between a container of a priming solution in openable fluid communication with multiple suspended flexible containers of a source liquid comprising the biological fluid;
wherein said controller is configured to control flow of said priming solution by a number and sequence of deliveries of said priming solution communicating with said multiple source containers through said multiple flow paths based on at least the total number of said multiple source containers of the biological fluid and wherein said controller is further configured to (i) allow for selection of either sequential delivery or simultaneous delivery of said priming solution to said multiple flow paths and said multiple source containers and to (ii) effect a pause in the flow of said priming solution of the selected delivery of said priming solution to allow for mixing of the priming solution with the source liquid in each of said multiple source containers, and to resume the selective delivery of said priming solution after the pause.

2. The system of claim 1 wherein said controller is configured to determine the volume of said priming solution to be delivered to each of said multiple source containers.

3. The system of claim 2 wherein said controller is configured to incrementally deliver said priming solution.

4. The system of claim 3 wherein said controller is configured to pause said incremental delivery of said priming solution, wherein said pause is of a predetermined duration.

5. The system of claim 1 wherein said controller is configured to deliver said priming solution at variable flow rates.

6. The system of claim 1 wherein said disposable fluid circuit includes a manifold providing fluid communication with said multiple source containers.

7. The system of claim 1 further comprising a sensor for detecting the presence of air within said fluid circuit and said controller is configured to effect re-priming of at least a portion of said disposable fluid circuit in response to said detecting.

8. The system of claim 1 wherein said controller is configured to effect delivery of said priming solution to each of said multiple source containers of the biological fluid in variable volumes.

9. The system of claim 1 wherein said controller is configured to effect delivery of said priming solution to each of said multiple source containers of the biological fluid incrementally.

10. The system of claim 1 wherein said controller is configured to effect delivery of said priming solution to each of said multiple source containers of the biological fluid at varying flow rates.

11. The system of claim 1 wherein said disposable fluid circuit includes a separation device comprising a spinning membrane separator.

12. The system of claim 1 wherein the controller is further configured to control the number and sequence of selective deliveries of said priming solution communicating with said multiple source containers through said multiple flow paths based on one or more of i) the source container(s) capacity(ies), ii) the number of deliveries of said priming solution, iii) the duration and interval of pauses, iv) the flow rate of the priming solution, and v) the composition of the source liquid.

13. The system of claim 1 comprising an alert and/or alarm condition that indicates incomplete or ineffective priming wherein said alert and/or alarm is triggered when the number of multiple source containers has been entered incorrectly.

Assignees

• Fenwal Inc

Inventors

• Schlinker Alaina
• Binninger Steven

Classifications

• A61M1/0281

  Apparatus for treatment of blood or blood constituents prior to transfusion, e.g. washing, filtering or thawing · CPC title

• A61M1/0209

  Multiple bag systems for separating or storing blood components · CPC title

• A61M2205/3393

  by weighing the reservoir · CPC title

• A61M1/0272

  Apparatus for treatment of blood or blood constituents prior to or for conservation, e.g. freezing, drying or centrifuging · CPC title

• A61M1/3644 Primary

  Mode of operation · CPC title