Compositions and methods for treating the eye

Patent metadata

Field	Value
Publication number	US-11357805-B2
Application number	US-202017029236-A
Country	US
Kind code	B2
Filing date	Sep 23, 2020
Priority date	Jul 27, 2018
Publication date	Jun 14, 2022
Grant date	Jun 14, 2022

Abstract

The present invention relates to compositions comprising one or more compounds and/or extracts which induce, promote and/or improve production/release/delivery/excretion of mucin from and/or in the cornea, and methods of using the compositions to treat the eye.

First claim

What is claimed is:

1. A composition for treating the eye comprising:
i) one or more extracts of the genus Pichia ; and
ii) an ophthalmologically acceptable carrier comprising one or more excipients selected from demulcents, tonicity agents, preservatives, chelating agents and buffering agents
wherein the composition is a sterile composition.

2. The composition according to claim 1 , wherein the species of the genus of Pichia is selected from Pichia anomala, Pichia guilliermondii, Pichia norvegensis, Pichia ohmeri and mixtures thereof.

3. The composition according to claim 2 , wherein the species of the genus of Pichia is Pichia anomala.

4. The composition of claim 1 , where in the one or more extracts of the genus Pichia are present at a concentration of from about 0.001% to about 95% by weight of the total composition.

5. The composition of claim 1 , where in the one or more extracts of the genus Pichia are present at a concentration of from about 0.005% to about 95% by weight of the total composition.

6. The composition of claim 1 , where in the one or more extracts of the genus Pichia are present at a concentration of from about 0.01% to about 90% by weight of the total composition.

7. The composition according to claim 1 , comprising a permeation enhancer.

8. The composition of claim 7 wherein the permeation enhancer is present at a concentration of from about 0.01% to about 20% (w/v) of the total composition.

9. The composition of claim 8 wherein the permeation enhancer is present at a concentration of from about 0.1% to 10% (w/v) of the total composition.

10. The composition of claim 9 wherein the permeation enhancer is present at a concentration of from about 0.25% to 5% (w/v) of the total composition.

11. The composition of claim 7 wherein the permeation enhancer is selected from polyoxyethylene, polyoxyethylene ethers of fatty acids, sorbitan monooleate, sorbitan monolaurate, polyoxyethylene monolaurate, polyoxyethylene sorbitan monolaurate, fusidic acid and derivatives thereof, ethylenediaminetetraacetic acetate (EDTA), disodium EDTA, cholic acid, deoxycholic acid, glycocholic acid, glycodeoxycholic acid, taurocholic acid, taurodeoxycholic acid, sodium cholate, sodium glycocholate, glycocholate, sodium deoxycholate, sodium taurocholate, sodium glycodeoxycholate, sodium taurodeoxycholate, chenodeoxycholic acid, urosdeoxycholic acid, saponins, glycyrrhizic acid, ammonium glycyrrhizide, decamethonium, decamethonium bromide, and dodecyltrimethylammonium bromide or mixtures of any of the above.

12. The composition of claim 1 wherein the Pichia genus extract comprises oligosaccharides and polysaccharides having a weight average molecular weight of from about 180 to about 800,000 Daltons.

13. The composition of claim 1 wherein the Pichia genus extract comprises oligosaccharides and polysaccharides having an average degree of polymerization (DP) of from DP 1 to DP 4444.

Assignees

• Johnson & Johnson Surgical Vision Inc

Inventors

• Li Wen-Hwa Ting
• Mahmood Khalid
• Parsa Ramine
• Randhawa Manpreet
• Bai Mingqi
• Holeva Kenneth T

Classifications

• A61K9/0048 Primary

  Eye, e.g. artificial tears · CPC title

• A61K47/36

  Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin · CPC title

• A61K36/064 Primary

  Saccharomycetales, e.g. baker's yeast · CPC title

• A61K47/10

  Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers · CPC title

• A61K9/08

  Solutions {(composition of solutions A61K47/00)} · CPC title