Transcutaneous sensor with dual electrodes and methods of detecting and compensating for withdrawal of a transcutaneous sensor from a patient

Patent metadata

Field	Value
Publication number	US-11357428-B2
Application number	US-201816174138-A
Country	US
Kind code	B2
Filing date	Oct 29, 2018
Priority date	Oct 30, 2017
Publication date	Jun 14, 2022
Grant date	Jun 14, 2022

Abstract

A transcutaneous sensor configured to measure one or more physiological conditions of a patient. The transcutaneous sensor includes a substrate and first and second working electrodes on the substrate. The first working electrode includes a first active sensing area and the second working electrode includes a second active sensing area. The first active sensing area of the first working electrode is longitudinally offset along the substrate from the second active sensing area of the second working electrode.

First claim

What is claimed is:

1. A method of detecting withdrawal of a transcutaneous sensor from a patient, the method comprising:
transducing, with a first working electrode and a second working electrode of the transcutaneous sensor, an analyte in the patient into a first current output and a second current output;
determining a current ratio of the first current output by the first working electrode of the transcutaneous sensor to the second current output by the second working electrode of the transcutaneous sensor;
comparing the current ratio to a size ratio defined by a first size of a first active sensing area of the first working electrode to a second size of a second active sensing area of the second working electrode; and
determining that the transcutaneous sensor has at least partially withdrawn from the patient based on the current ratio being different than the size ratio.

2. The method of claim 1 , further comprising compensating for a reduction in the current output from one of the first and second working electrodes due to the partial withdrawal of the transcutaneous sensor using a difference between the current ratio and the size ratio.

3. The method of claim 1 , wherein the first active sensing area has a first size and wherein the second active sensing area has a second size different than the first size.

4. The method of claim 1 , wherein the first active sensing area has a first size and wherein the second active sensing area has a second size substantially equal to the first size.

5. The method of claim 1 , wherein the first active sensing area comprises a first plurality of sensing spots and wherein the second active sensing area comprises a second plurality of sensing spots.

6. The method of claim 5 , wherein a size of each sensing spot of the first plurality is substantially the same as a size of each sensing spot of the second plurality.

7. The method of claim 6 , wherein the first plurality of sensing spots comprises a greater number of sensing spots than the second plurality of sensing spots.

8. The method of claim 1 , wherein a proximalmost end of the first active sensing area is spaced apart from a distal end of a substrate by a first distance and a proximalmost end of the second active sensing area is spaced apart from the distal end of the substrate by a second distance different than the first distance.

9. The method of claim 1 , wherein a distalmost end of the first active sensing area is spaced apart from a distal end of a substrate by a first distance and a distalmost end of the second active sensing area is spaced apart from the distal end of the substrate by a second distance different than the first distance.

10. The method of claim 1 , wherein a longitudinally centered portion of the first active sensing area is offset from a longitudinally centered portion of the second active sensing area.

11. The method of claim 1 , further comprising a reference electrode on a substrate.

12. The method of claim 11 , further comprising a counter electrode on the substrate.

13. The method of claim 12 , further comprising a first dielectric insulator layer between the reference electrode and the substrate and a second dielectric insulator layer between the counter electrode and the substrate.

14. The method of claim 1 , wherein the first working electrode is on a first side of a substrate and the second working electrode is on a second side of the substrate opposite the first side.

15. The method of claim 1 , wherein the first active sensing area and the second active sensing area comprise an analyte-specific enzyme and an electron transfer agent.

16. The method of claim 15 , wherein the first active sensing area and the second active sensing area further comprise a cross linker.

17. The method of claim 15 , wherein the analyte-specific enzyme is glucose oxidase.

18. The method of claim 15 , wherein the electron transfer agent is a redox polymer.

19. The method of claim 1 , further comprising a membrane overlaying the first and second active sensing areas.

Assignees

• Abbott Diabetes Care Inc

Inventors

• Feldman Benjamin

Classifications

• A61B5/14865 Primary

  invasive, e.g. introduced into the body by a catheter or needle or using implanted sensors · CPC title

• A61B5/14532

  for measuring glucose, e.g. by tissue impedance measurement · CPC title