Blood vessel analysis apparatus, medical image diagnosis apparatus, and blood vessel analysis method

Patent metadata

Field	Value
Publication number	US-11357409-B2
Application number	US-201514716433-A
Country	US
Kind code	B2
Filing date	May 19, 2015
Priority date	Nov 19, 2012
Publication date	Jun 14, 2022
Grant date	Jun 14, 2022

Abstract

A time-series morphology index and a time-series shape deformation index of the analysis target region on a time-series medical image are calculated by image processing. A dynamical model of a structural fluid analysis of the analysis target region is temporarily structured, based on the time-series morphology index, the time-series shape deformation index, and the time-series medical image. A latent variable of the identification region is identified so that at least one of a prediction value of a blood vessel morphology index and a blood flow volume index based on the temporarily structured dynamical model match with at least one of an observation value of the blood vessel morphology index and the blood flow volume index measured.

First claim

The invention claimed is:

1. A tubular structure analysis apparatus comprising:
a storage configured to store data of a plurality of images taken over time of a tubular structure of a subject;
a setting circuitry configured to set an analysis target region in a tubular structure region included in the plurality of images, and set an identification region for a latent variable in the analysis target region;
a calculation circuitry configured to calculate a time-series morphology index and a time-series shape deformation index of the analysis target region by performing image processing on the plurality of images;
a structuring circuitry configured to temporarily structure a dynamical model of a structural fluid analysis of the analysis target region, based on the time-series morphology index, the time-series shape deformation index, and the plurality of images;
an identification circuitry configured to estimate a prediction value of the time-series morphology index and a predicted flow volume index by performing stress analysis and fluid analysis on the structured dynamical model, and to identify the latent variable of the identification region so that the prediction value of the time-series morphology index and predicted flow volume index is in conformity with an observation value of the time-series morphology index calculated by the calculation circuitry and the predicted flow volume index;
an analysis circuitry configured to calculate a time-series dynamical index and/or a time-series fluid index by repeatedly performing perform stress analysis and/or fluid analysis on the dynamical model; and
an output circuitry configured to output the time-series dynamical index and/or the time-series fluid index, wherein
the identification circuitry is configured to:
estimate the prediction value of the time-series morphology index by performing stress analysis on the temporarily structured dynamical model,
estimate the prediction value of the flow volume index by performing fluid analysis on the temporarily structured dynamical model,
set data distribution of errors between the prediction value of the time-series morphology index and the observation value and/or errors between the prediction value of the flow volume index and the observation value, allocate a prior distribution of errors to the latent variable of the temporarily structured dynamical model, calculate a posterior distribution based on the prior distribution and the data distribution, and identify the latent variable from a statistic value of the posterior distribution, and
wherein the output circuitry is configured to display a time-series dynamical model in animation with color values in accordance with the time-series dynamical index and/or the time-series fluid index.

2. The apparatus according to claim 1 , wherein the identification circuitry identifies, as the latent variable, at least one of a material model of the identification region, a boundary condition of a flow inlet and outlet in the identification region, a load condition including an internal pressure distribution based on a stream in the identification region, and a geometric structure in the identification region.

3. The apparatus according to claim 2 , wherein the identification circuitry includes:
a blood vessel stress analysis circuitry configured to estimate a prediction value of the morphology index by performing stress analysis on the temporarily structured dynamical model;
a blood fluid analysis circuitry configured to estimate a prediction value of the flow volume index by performing fluid analysis on the temporarily structured dynamical model;
a first statistical identification circuitry configured to statistically identify the latent variable so that the prediction value of the morphology index is in conformity with the observation value of the morphology index; and
a second statistical identification circuitry configured to statistically identify the latent variable so that the prediction value of the flow volume index is in conformity with the observation value of the flow volume index.

4. The apparatus according to claim 1 , further comprising:
a control circuitry configured to control the structuring circuitry and the identification circuitry, and to store a predetermined identification termination index, and to repeat to estimate a prediction value of the time-series morphology index and a predicted flow volume index by performing stress analysis and fluid analysis on the structured dynamical model, while the latent variable is changed,
wherein the control circuitry determines whether the predetermined identification termination index attains an already-determined value every time the identification circuitry identifies the latent variable, and in a case where the identification termination index is determined not to have attained the already-determined value, the control circuitry controls the structuring circuitry to use the identified latent variable to restructure the dynamical model, and controls the identification circuitry to identify a latent variable of the restructured dynamical model, and in a case where the identification termination index is determined to have attained the already-determined value, the control circuitry controls the structuring circuitry to set a latest dynamical model as the ultimate dynamical model and to further output the latest dynamical model.

5. The apparatus according to claim 4 , wherein:
the analysis circuitry is further configured to calculate a time-series mechanics index by performing stress analysis on the ultimate dynamical model; and the apparatus further comprise;
a display circuitry configured to display the time-series mechanics index.

6. The apparatus according to claim 4 , further comprising:
the analysis circuitry configured to calculate a time-series fluid index by performing fluid analysis on the ultimate dynamical model; and
a display circuitry configured to display the time-series fluid index.

7. The apparatus according to claim 5 , further comprising:
an amending circuitry configured to obtain the observation value of at least one of the time-series mechanics index and the flow volume index, and amend a shape of a blood vessel region included in the plurality of images so that a prediction value of at least one of a flow volume index and the time-series mechanics index based on the ultimate dynamical model is in conformity with the observation value of at least one of the time-series mechanics index and the flow volume index.

8. The apparatus according to claim 2 , wherein the structuring circuitry structures a shape model of the analysis target region based on the time-series morphology index and the plurality of images, and allocates the time-series shape deformation index to the shape model as a forcible displacement, and structures the dynamical model by allocating the latent variable.

9. The apparatus according to claim 8 , wherein the structuring circuitry classifies the dynamical model into a material model identification region and a non-identification region, and allocates a constraint condition of forcible displacement a surface portion of the material model identification region, and does not allocate the constraint condition of forcible displacement to an inside of the material model identification region, and allocates the constraint condition of forcible displacement to the surface portion and the inside of the non-identification region.

10. The apparatus according to claim 1 , further comprising:
an association storage configured to receive and store a morphology index, a material model parameter, and a time-series space distribution of an internal pressure caused by a liquid pressure base

Assignees

• Toshiba Kk

Inventors

• Hirohata Kenji
• Ooga Junichiro

Classifications

• G06T7/0016 Primary

  involving temporal comparison · CPC title

• G06T2207/10072

  Tomographic images · CPC title

• A61B5/026

  Measuring blood flow {(A61B3/1233, A61B3/1241 take precedence)} · CPC title

• A61B6/5217

  extracting a diagnostic or physiological parameter from medical diagnostic data · CPC title

• G06T2207/30104

  Vascular flow; Blood flow; Perfusion · CPC title