Sugar compositions for tableting by direct compression

Patent metadata

Field	Value
Publication number	US-11350658-B2
Application number	US-201816205696-A
Country	US
Kind code	B2
Filing date	Nov 30, 2018
Priority date	Jul 21, 2014
Publication date	Jun 7, 2022
Grant date	Jun 7, 2022

Abstract

A directly compressible composition includes more than 30% by weight of allulose. The directly compressible composition can form tablets. A method for the manufacture of allulose granules includes: a step (a) of preparing a granulation liquid comprising allulose; a step (b) of granulating powdery allulose, by applying the granulation liquid obtained in step (a) onto moving powdery allulose; a step (c), simultaneous with step (b), of drying the granules obtained in step (b); a step (c′) of maturation of the granules obtained in step (c); and a step (d) of recovering the granules obtained in step (c) or (c′).

First claim

What is claimed is:

1. A method of preparing a direct compression excipient in a directly compressible composition by providing an effective amount of allulose granules as the excipient,
wherein said allulose granules are obtained according to a method comprising:
step (a) of preparing a granulation liquid consisting of allulose and water;
step (b) of granulating powdery allulose, by applying the granulation liquid obtained in step (a) onto moving powdery allulose to obtain allulose granules;
step (c), simultaneous with step (b), of drying the allulose granules obtained in step (b);
step (c′) of maturation of the allulose granules obtained in step (c); and
step (d) of recovering the allulose granules obtained in step (c) or (c′); and wherein said allulose granules contain no binders other than allulose.

2. The method according to claim 1 , wherein said allulose granules are compressible in the sole presence of a lubricant to form a tablet having a diameter of 13 mm, a thickness of 6 mm, an apparent density of 1.35 g/ml±0.02 g/ml, a cylindrical shape with convex faces with a radius of curvature of 13 mm, and a hardness of greater than 50 N.

3. The method according to claim 1 , wherein the allulose granules are further used as a sweetener, a low-calorie sweetener, a health ingredient having physiological functions, or combination thereof.

4. A method of preparing allulose granules, comprising:
step (a) of preparing a granulation liquid consisting of allulose and water;
step (b) of granulating powdery allulose, by applying the granulation liquid obtained in step (a) onto moving powdery allulose to obtain allulose granules;
step (c), simultaneous with step (b), of drying the allulose granules obtained in step (b);
step (c′) of maturation of the allulose granules obtained in step (c); and
step (d) of recovering the allulose granules obtained in step (c) or (c′), wherein said allulose granules contain no binders other than allulose.

5. The method according to claim 4 , wherein said allulose granules are compressible in the sole presence of a lubricant to form a tablet having a diameter of 13 mm, a thickness of 6 mm, an apparent density of 1.35 g/ml±0.02 g/ml, a cylindrical shape with convex faces with a radius of curvature of 13 mm, and a hardness of greater than 50 N.

Assignees

• Roquette Freres

Inventors

• Boit Baptiste
• Lanos Pierre
• Buquet Fabrice

Classifications

• A23L29/30

  containing carbohydrate syrups; containing sugars; containing sugar alcohols, e.g. xylitol; containing starch hydrolysates, e.g. dextrin (products from apiculture A23L21/20; artificial sweetening agents A23L27/30) · CPC title

• A23L33/20 Primary

  Reducing nutritive value; Dietetic products with reduced nutritive value · CPC title

• A23L27/33 Primary

  containing sugars or derivatives · CPC title

• A61K31/7004

  Monosaccharides having only carbon, hydrogen and oxygen atoms · CPC title

• A61P3/10

  for hyperglycaemia, e.g. antidiabetics · CPC title