Systems and methods for performing multiple precurser, neutral loss and product ion scans in a single ion trap
US-2019035614-A1 · Jan 31, 2019 · US
Precursor and neutral loss scan in an ion trap
US11348778B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-11348778-B2 |
| Application number | US-201615772738-A |
| Country | US |
| Kind code | B2 |
| Filing date | Nov 2, 2016 |
| Priority date | Nov 2, 2015 |
| Publication date | May 31, 2022 |
| Grant date | May 31, 2022 |
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- Title
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Abstract
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The invention generally relates to systems and methods for precursor and neutral loss scan in an ion trap. In certain aspects, the invention provides a system that includes a mass spectrometer having an ion trap, and a central processing unit (CPU). The CPU includes storage coupled to the CPU for storing instructions that when executed by the CPU cause the system to excite a precursor ion and eject a product ion in the single ion trap.
First claim
Opening claim text (preview).
What is claimed is: 1. A system comprising: a mass spectrometer comprising a single rectilinear ion trap; and a central processing unit (CPU), and storage coupled to the CPU and storing instructions that when executed by the CPU cause the system to apply to the single ion trap a constant alternating current (AC) frequency and ramping a radio frequency (RF) voltage in a reverse direction in order to excite a precursor ion and eject a product ion in the single ion trap. 2. The system according to claim 1 , wherein both the excitation of the precursor ion and the ejection of the product ion occur simultaneously. 3. The system according to claim 1 , wherein the excitation of the precursor ion occurs through application of at least two signals to the single ion trap. 4. The system according to claim 3 , wherein the ejection of the product ion occurs through simultaneous application of a third signal to the ion trap. 5. The system according to claim 4 , wherein the third signal comprises a variable frequency that results in ejection of the corresponding product ion from the ion trap. 6. The system according to claim 4 , wherein the product ion has a neutral loss and the third signal is configured to scan a frequency of the product ion at a constant mass offset from the precursor ion that corresponds to the neutral loss. 7. The system according to claim 1 , wherein the mass spectrometer is a miniature mass spectrometer.
Assignees
Inventors
Classifications
Three-dimensional ion traps, i.e. comprising end-cap and ring electrodes · CPC title
- H01J49/0081Primary
Tandem in time, i.e. using a single spectrometer · CPC title
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- What does patent US11348778B2 cover?
- The invention generally relates to systems and methods for precursor and neutral loss scan in an ion trap. In certain aspects, the invention provides a system that includes a mass spectrometer having an ion trap, and a central processing unit (CPU). The CPU includes storage coupled to the CPU for storing instructions that when executed by the CPU cause the system to excite a precursor ion and e…
- Who is the assignee on this patent?
- Purdue Research Foundation
- What technology area does this patent fall under?
- Primary CPC classification H01J49/0081. Mapped technology areas include Electricity.
- When was this patent published?
- Publication date Tue May 31 2022 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 12 related publications on this page (citations in our corpus or others sharing the same primary CPC).