Endoscopic sympathectomy systems and methods

Patent metadata

Field	Value
Publication number	US-11344731-B2
Application number	US-201916252207-A
Country	US
Kind code	B2
Filing date	Jan 18, 2019
Priority date	May 29, 2012
Publication date	May 31, 2022
Grant date	May 31, 2022

Abstract

A system for controlled sympathectomy procedures is disclosed. A system for controlled micro ablation procedures is disclosed. Methods for performing a controlled surgical procedure are disclosed. A system for performing controlled surgical procedures in a minimally invasive manner is disclosed. An implantable device for monitoring and/or performing a neuromodulation procedure is disclosed.

First claim

What is claimed is:

1. A microsurgical tool comprising:
a substrate; and
a netting coupled to the substrate;
the netting comprising:
a plurality of sensing tips; and
one or more actuating elements;

wherein the one or more actuating elements are configured to wrap at least a portion of the netting around a tissue structure;
wherein at least one of the plurality of sensing tips comprises one or more electrodes configured to measure local neural activity associated with tissues in a vicinity of the tissue structure and to convey one or more electrophysiological signals representing the measured local neural activity; and
wherein the netting comprises a porous silk structure.

2. The microsurgical tool in accordance with claim 1 , wherein the measured local neural activity is related to one or more of water concentration, tissue tone, evoked potential, remotely stimulated nervous activity, sympathetic nervous activity, an electromyographic signal [EMG], a mechanomyographic signal [MMG], a local field potential, an electroacoustic event, vasodilation, vessel wall stiffness, muscle sympathetic nerve activity [MSNA], central sympathetic drive, nerve traffic, or combinations thereof.

3. The microsurgical tool in accordance with claim 1 , further comprising a control circuit embedded in the substrate, the control circuit being configured to condition the one or more electrophysiological signals prior to conveying the one or more electrophysiological signals outside a body.

4. The microsurgical tool in accordance with claim 3 , wherein conditioning the one or more electrophysiological signals prior to conveying the one or more electrophysiological signals outside the body comprises one or more of pre-amplification, radio frequency (RF) signal routing, analog to digital conversion, signal buffering, signal isolation, multiplexing and demultiplexing functions, and communication with externally located hardware.

5. The microsurgical tool in accordance with claim 1 , wherein at least one of the plurality of sensing tips comprises one or more stimulating electrodes configured to provide at least one of a stimulating and an ablating current to adjacent tissues.

6. The microsurgical tool in accordance with claim 1 , wherein at least one of the one or more actuating elements comprises an electroactive material actuator comprising an active material configured to change shape upon command.

7. The microsurgical tool in accordance with claim 6 , wherein the active material comprises one or more of a shape memory material, an electroactive polymer and a piezoceramic material.

8. The microsurgical tool in accordance with claim 1 , wherein at least one of the one or more actuating elements comprises a capillary force element.

9. The microsurgical tool in accordance with claim 1 , wherein the netting comprises at least one of a webbing, an arched structure, a sock-shaped structure, and a donut-shaped structure.

10. The microsurgical tool in accordance with claim 1 , wherein the netting comprises at least one of one or more fibers, one or more wires and one or more ribbons woven into the porous silk structure.

11. The microsurgical tool in accordance with claim 1 , wherein the porous silk structure comprises a silk flexcircuit comprising a webbing of flexcircuit elements providing electrical interconnects between the plurality of sensing tips and a control circuit embedded in the substrate.

12. The microsurgical tool in accordance with claim 11 , wherein the flexcircuit elements have a thickness less than 10 micrometers.

13. A microsurgical tool comprising:
a substrate; and
a netting coupled to the substrate;
the netting comprising:
a plurality of sensing tips; and
one or more actuating elements;

wherein the one or more actuating elements are configured to wrap at least a portion of the netting around a tissue structure;
wherein at least one of the plurality of sensing tips comprises one or more electrodes configured to measure local neural activity associated with tissues in a vicinity of the tissue structure and to convey one or more electrophysiological signals representing the measured local neural activity; and
wherein the netting comprises one or more interwoven wires, the plurality of sensing tips being coupled to the one or more interwoven wires such that the at least one sensing tip is configured to contact a surface of the tissue structure when at least the portion of the netting is wrapped against the tissue structure via actuation of the one or more actuating elements.

14. The microsurgical tool in accordance with claim 13 , wherein the one or more interwoven wires comprises two or more superelastic wires.

15. The microsurgical tool in accordance with claim 14 , wherein at least one of the two or more superelastic wires comprises at least one of a nitinol wire and a steel spring wire.

16. The microsurgical tool in accordance with claim 13 , wherein the one or more interwoven wires provide an electrical interconnection between the plurality of sensing tips and a control circuit embedded in the substrate.

17. A system comprising:
a microsurgical tool comprising a substrate and a netting coupled to the substrate, the netting comprising a plurality of sensing tips and one or more actuating elements; and
a controller coupled to the microsurgical tool, the controller being configured to actuate the one or more actuating elements to wrap at least a portion of the netting around a tissue structure;
wherein at least one of the plurality of sensing tips comprises one or more electrodes configured to measure local neural activity associated with tissues in thea vicinity of the tissue structure and to convey one or more electrophysiological signals representing the measured local neural activity to the controller; and
wherein the netting comprises a porous silk structure.

18. The system in accordance with claim 17 , wherein the netting comprises one or more interwoven wires, the plurality of sensing tips being coupled to the one or more interwoven wires such that the at least one sensing tip is configured to contact a surface of the tissue structure when at least the portion of the netting is wrapped against the tissue structure via actuation of the one or more actuating elements.

19. The system in accordance with claim 17 , wherein the netting further comprises at least one of one or more fibers, one or more wires and one or more ribbons woven into the porous silk structure.

20. The system in accordance with claim 17 , wherein at least one of the one or more actuating elements comprises an electroactive material actuator comprising an active material configured to change shape upon command.

Assignees

• Autonomix Medical Inc

Inventors

• Toth Landy
• Schwartz Robert

Classifications

• A61B5/24

  Detecting, measuring or recording bioelectric or biomagnetic signals of the body or parts thereof · CPC title

• A61B5/283 Primary

  Invasive · CPC title

• A61B2018/00345

  Vascular system · CPC title

• A61B2018/00839

  Bioelectrical parameters, e.g. ECG, EEG · CPC title

• A61B5/4839

  combined with drug delivery · CPC title