Use of PEBA having long blocks for the manufacture of all or part of a catheter

Patent metadata

Field	Value
Publication number	US-11344654-B2
Application number	US-202016869677-A
Country	US
Kind code	B2
Filing date	May 8, 2020
Priority date	Apr 11, 2014
Publication date	May 31, 2022
Grant date	May 31, 2022

Abstract

The present invention relates to the use of a copolymer containing polyether blocks and polyamide blocks for manufacturing an inflatable catheter element, such as a catheter balloon, with improved bursting strength, in which said copolymer has the following characteristics: a number-average molecular mass of the PE blocks greater than 500 g/mol, and a number-average molecular mass of the PA blocks greater than 10,000 g/mol.

First claim

What is claimed is:

1. An inflatable catheter element comprising a copolymer containing polyether blocks and polyamide blocks in which said copolymer has the following characteristics:
a) number-average molecular mass of the polyether blocks greater than 500 g/mol,
b) number-average molecular mass of the polyamide blocks greater than 10,000 g/mol, and
c) a majority of monomer units of the polyether blocks are PTMG monomer units,
wherein the polyether blocks represent 1% to 10% by weight, relative to the total weight of the copolymer, and said polyamide blocks represent 80% to 99% by weight, relative to the total weight of the copolymer.

2. The inflatable catheter element of claim 1 , wherein the Shore D hardness of the copolymer is greater than or equal to 72.

3. The inflatable catheter element of claim 1 , wherein the flexural modulus of elasticity, as measured by of the copolymer is greater than 525 MPa.

4. The inflatable catheter element of claim 1 , wherein the number average molecular mass of the polyether blocks is greater than 600 g/mol.

5. The inflatable catheter element of claim 1 , wherein the number average molecular mass of the polyamide blocks is within the range from 12,000 to 32,000 g/mol.

6. The inflatable catheter element of claim 1 , wherein the polyamide blocks are formed from at least one monomer chosen from: 6, 11, 12, 4.6, 4.12, 4.14, 4.18, 6.6, 6.10, 6.12, 6.14, 6.18, piperazine, 10, 9.6, 9.12, 10.10, 10.12, 10.14, 10.18, 10.36, 10.T, 6.T, 9.T, MXD.6, MXD.10, BMACM.10, BMACM.12, BMACM.14. BMACM.18, BMACM.36, PACM.10, PACM.14, PACM.18. PACM.36, random and/or block copolymers.

7. The inflatable catheter element of claim 1 , wherein said at least one polyether block comprises at least one polyether selected from the group consisting of polyalkylene ether polyols, PEG, PPG, PO3G, PTMG, polyesters containing polyoxyalkylene sequences bearing NH.sub.2 chain ends, random and/or block copolymers thereof, and mixtures thereof.

8. The inflatable catheter element of claim 1 , wherein the copolymer comprises polyether blocks composed solely of PTMG.

9. The inflatable catheter element of claim 1 , wherein said inflatable catheter element has:
a) a flexural modulus of elasticity of less than 1000 MPa and greater than measured according to international standard ISO 178;
b) a bursting strength or tensile strength, wherein the threshold stress is greater than 20 MPa and the threshold strain is greater than 22%, measured according to standard ISO 527; and
c) the difference between the threshold stress and the strain at the flow plateau is less than 0.5 MPa, and for which the ratio between the threshold strain and the strain at the flow plateau is greater than 0.5, the stresses and strains being measured according to standard ISO 527.

10. A catheter comprising the inflatable catheter element of claim 1 .

11. The catheter of claim 10 , wherein said inflatable catheter element has a wall thickness within the range of 1 to 250 μm.

Assignees

• Arkema France

Inventors

• Eustache Rene-Paul
• Malet Frederic
• Gamache Eric
• Reyna-Valencia Alejandra
• Rauline Damien

Classifications

• C08L2205/035

  containing four or more polymers in a blend · CPC title

• A61M25/10

  Balloon catheters ({A61M25/0125 takes precedence; embolectomy A61B17/22032; retractors A61B17/02;} inflatable balloons for placing stents or stent-grafts A61F2/958 {; stomach balloons for treatment of obesity A61F5/0003; oesophagal tubes A61J15/00}) · CPC title

• A61M25/1029

  Production methods of the balloon members, e.g. blow-moulding, extruding, deposition or by wrapping a plurality of layers of balloon material around a mandril · CPC title

• C08L2205/03

  containing three or more polymers in a blend · CPC title

• A61L29/06 Primary

  obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds · CPC title