Compositions and methods of using the same for decontamination of skin

Patent metadata

Field	Value
Publication number	US-11344491-B2
Application number	US-201615762934-A
Country	US
Kind code	B2
Filing date	Sep 22, 2016
Priority date	Sep 23, 2015
Publication date	May 31, 2022
Grant date	May 31, 2022

Abstract

The present disclosure provides compositions comprising decontaminating compounds, and pharmaceutically acceptable salts thereof and methods of treating or preventing a contamination in a mammal, in particular, the composition can include a mixture of polyvinyl acetate and povidone, a coblock polymer of ethylene oxide and propylene oxide, a polyvinyl alcohol, or combinations thereof, and an aqueous suspending agent.

First claim

The invention claimed is:

1. A topical composition consisting essentially of:
from about 5% to about 20% weight percentage of a mixture of polyvinyl acetate and povidone or pharmaceutically acceptable salt thereof as part of the total weight of the composition;
from about 1% to about 5% weight percentage of poloxamer 407 or pharmaceutically acceptable salt thereof, as part of the total weight of the composition;
from about 1% to about 5% weight percentage of carboxymethyl cellulose or pharmaceutically acceptable salt thereof as part of the total weight of the composition;
from about 10% to about 25% weight percent of Fuller's earth or pharmaceutically acceptable salt thereof as part of the total weight of the composition;
from about 1% to about 10% weight percent of a phyllosilicate or pharmaceutically acceptable salt thereof as part of the total weight of the composition;
from about 20% to about 50% weight percent of ethanol as part of the total weight of the composition; and
from about 10% to about 50% weight percent of water as part of the total weight of the composition.

2. The topical composition of claim 1 , further comprising one or more different types of nanoparticles.

3. A kit comprising the topical composition of claim 1 and an applicator.

4. A method of decontaminating a subject in need thereof comprising:
contacting one or more compositions to the skin of the subject at a location of the subject's body where the skin has been exposed to an agent comprising a radioactive isotope; wherein the composition consisting essentially of:
from about 5% to about 20% weight percentage of a mixture of polyvinyl acetate and povidone or pharmaceutically acceptable salt thereof as part of the total weight of the composition;
from about 1% to about 5% weight percentage of poloxamer 407 or pharmaceutically acceptable salt thereof, as part of the total weight of the composition;
from about 1% to about 5% weight percentage of carboxymethyl cellulose or pharmaceutically acceptable salt thereof as part of the total weight of the composition;
from about 10% to about 25% weight percent of Fuller's earth or pharmaceutically acceptable salt thereof as part of the total weight of the composition;
from about 1% to about 10% weight percent of a phyllosilicate or pharmaceutically acceptable salt thereof as part of the total weight of the composition;
from about 20% to about 50% weight percent of ethanol as part of the total weight of the composition; and
from about 10% to about 50% weight percent of water as part of the total weight of the composition.

5. The method of claim 4 , wherein the step of contacting is performed no less than about 10, 20 or 30 minutes after the subject is exposed to the radioactive isotope.

6. The method of claim 4 further comprising massaging the one or more compositions into the skin of the subject at a location of the subject's body where the skin has been exposed to the radioactive isotope for about 2 minutes after contacting the composition to the skin of the subject.

7. A method of preventing death of a subject exposed to a radioactive isotope comprising contacting one or more compositions to the skin of the subject at a location of the subject's body where the skin has been exposed to the radioactive isotope, wherein the composition consisting essentially of:
from about 5% to about 20% weight percentage of a mixture of polyvinyl acetate and povidone or pharmaceutically acceptable salt thereof as part of the total weight of the composition;
from about 1% to about 5% weight percentage of poloxamer 407 or pharmaceutically acceptable salt thereof, as part of the total weight of the composition;
from about 1% to about 5% weight percentage of carboxymethyl cellulose or pharmaceutically acceptable salt thereof as part of the total weight of the composition;
from about 10% to about 25% weight percent of Fuller's earth or pharmaceutically acceptable salt thereof as part of the total weight of the composition;
from about 1% to about 10% weight percent of a phyllosilicate or pharmaceutically acceptable salt thereof as part of the total weight of the composition;
from about 20% to about 50% weight percent of ethanol as part of the total weight of the composition; and
from about 10% to about 50% weight percent of water as part of the total weight of the composition.

8. The method of claim 7 , wherein the step of contacting is performed no less than about 10, 20 or 30 minutes after the subject is exposed to the radioactive isotope.

9. The method of claim 7 , wherein the step of contacting is performed no less than about 5 hours after the subject is exposed to the radioactive isotope.

10. A method of decreasing the amount of exposure of a radioactive isotope to the stratum corneum of a subject exposed to the radioactive isotope comprising contacting any one or more compositions to the skin of the subject at a location of the subject's body where the skin has been exposed to the radioactive isotope, wherein the composition consisting essentially of:
from about 5% to about 20% weight percentage of a mixture of polyvinyl acetate and povidone or pharmaceutically acceptable salt thereof as part of the total weight of the composition;
from about 1% to about 5% weight percentage of poloxamer 407 or pharmaceutically acceptable salt thereof, as part of the total weight of the composition;
from about 1% to about 5% weight percentage of carboxymethyl cellulose or pharmaceutically acceptable salt thereof as part of the total weight of the composition;
from about 10% to about 25% weight percent of Fuller's earth or pharmaceutically acceptable salt thereof as part of the total weight of the composition;
from about 1% to about 10% weight percent of a phyllosilicate or pharmaceutically acceptable salt thereof as part of the total weight of the composition;
from about 20% to about 50% weight percent of ethanol as part of the total weight of the composition; and
from about 10% to about 50% weight percent of water as part of the total weight of the composition.

11. A method of treating a subject exposed to one or a plurality of radioactive substances, the method comprising contacting a therapeutically effective dose of one or more compositions to the skin of the subject at a location of the subject's body where the skin has been exposed to the radioactive substances, wherein the composition consists essentially of:
from about 5% to about 20% weight percentage of a mixture of polyvinyl acetate and povidone or pharmaceutically acceptable salt thereof as part of the total weight of the composition;
from about 1% to about 5% weight percentage of poloxamer 407 or pharmaceutically acceptable salt thereof, as part of the total weight of the composition;
from about 1% to about 5% weight percentage of carboxymethyl cellulose or pharmaceutically acceptable salt thereof as part of the total weight of the composition;
from about 10% to about 25% weight percent of Fuller's earth or pharmaceutically acceptable salt thereof as part of the total weight of the composition;
from about 1% to about 10% weight percent of a phyllosilicate or pharmaceutically acceptable salt thereof as part of the total weight of the composition;
from about 20% to about 50% weight percent of ethanol as part of the total weight of the composition; and
from about 10% to about 50% weight percent of water as part of the total weight of the composition.

12. The method of claim 11 , wherein contacting any one or more compositions to the skin of the subject at a location of the subject's body where the skin has been exposed to the radioactive substance occurs no less than about 10 minutes prior to

Assignees

• Univ California

Inventors

• Maibach Howard I
• Hui Xiaoying
• Zhu Hanjiang

Classifications

• A61K9/0014 Primary

  Skin, i.e. galenical aspects of topical compositions (non-active ingredients are additionally classified in A61K47/00; A61K9/0009, A61K9/0021, A61K9/7015, A61K9/7023 take precedence; cosmetic preparations A61K8/00, A61Q; preparations for wound dressings or bandages A61L26/00) · CPC title

• A61K8/044

  Suspensions · CPC title

• A61K47/38

  Cellulose; Derivatives thereof · CPC title

• A61K47/34

  Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers (A61K47/10 takes precedence) · CPC title

• A61K8/8135

  Compositions of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by an acyloxy radical of a saturated carboxylic acid, of carbonic acid or of a haloformic acid; Compositions of derivatives of such polymers, e.g. vinyl esters (polyvinylacetate) · CPC title