Human milk oligosaccharides to promote growth of beneficial bacteria

Patent metadata

Field	Value
Publication number	US-11337990-B2
Application number	US-201113335323-A
Country	US
Kind code	B2
Filing date	Dec 22, 2011
Priority date	Dec 31, 2010
Publication date	May 24, 2022
Grant date	May 24, 2022

Abstract

Disclosed are nutritional compositions including human milk oligosaccharides that can be administered to individuals including preterm infants, infants, toddlers, and children for improving gastrointestinal function and tolerance, as well as the growth of beneficial bacteria. Additional suitable methods of using the nutritional compositions including the human milk oligosaccharides are also disclosed.

First claim

What is claimed is:

1. A method of stimulating enteric nerve cells in the gastrointestinal tract of an individual presenting signs of feeding intolerance, the method comprising administering to the individual a nutritional composition comprising 2′-fucosyllactose in a concentration of from about 0.001 mg/mL to less than 2.0 mg/mL,
a macronutrient selected from the group consisting of fat, protein, carbohydrate, and combinations thereof;
a polyunsaturated fatty acid selected from docosahexaenoic acid, arachidonic acid, and combinations thereof;
a nucleotides comprising cytidine 5 ‘-monophosphate, uridine 5’-monophosphate, adenosine 5 ‘-monophosphate, guanosine 5’-monophosphate, and inosine 5′-monophosphate;
a carotenoid selected from lutein, lycopene, beta-carotene, and combinations thereof; and
wherein the nutritional composition does not comprise a probiotic.

2. The method of claim 1 , wherein the individual is an infant, a toddler, or a child.

3. A method of stimulating enteric nerve cells in the gastrointestinal tract of an individual presenting signs of feeding intolerance, the method comprising administering to the individual a nutritional composition comprising 2′-fucosyllactose in a concentration of from greater than 2.5 mg/mL to about 20 mg/mL,
a macronutrient selected from the group consisting of fat, protein, carbohydrate, and combinations thereof;
a polyunsaturated fatty acid selected from docosahexaenoic acid, arachidonic acid, and combinations thereof;
a nucleotides comprising cytidine 5′-monophosphate, uridine 5′-monophosphate, adenosine 5′-monophosphate, guanosine 5′-monophosphate, and inosine 5′-monophosphate;
a carotenoid selected from lutein, lycopene, beta-carotene, and combinations thereof; and
wherein the nutritional composition does not comprise a probiotic.

4. A method of improving at least one of gut motility and gut contractility in the gastrointestinal tract of an individual presenting signs of feeding intolerance, the method comprising administering a nutritional composition comprising 2′-fucosyllactose in a concentration of from about 0.001 mg/mL to less than 2.0 mg/mL to the individual in need thereof;
a polyunsaturated fatty acid selected from docosahexaenoic acid, arachidonic acid, and combinations thereof;
a nucleotides comprising cytidine 5′-monophosphate, uridine 5′-monophosphate, adenosine 5′-monophosphate, guanosine 5′-monophosphate, and inosine 5′-monophosphate;
a carotenoid selected from lutein, lycopene, beta-carotene, and combinations thereof; and
wherein the nutritional composition does not comprise a probiotic.

5. The method of claim 4 , wherein the individual is an infant, a toddler, or a child.

Assignees

• Buck Rachael
• Chow Jomay
• Davis Steven R
• Abbott Lab

Inventors

• Buck Rachael
• Chow Jomay
• Davis Steven R

Classifications

• A61P1/08

  for nausea, cinetosis or vertigo; Antiemetics · CPC title

• A61P29/00

  Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID] · CPC title

• A61P1/12

  Antidiarrhoeals · CPC title

• A61P1/14

  Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents · CPC title

• A23V2002/00

  Food compositions, function of food ingredients or processes for food or foodstuffs · CPC title