Tooth capping method with amelogenin

Patent metadata

Field	Value
Publication number	US-11337777-B2
Application number	US-202117458955-A
Country	US
Kind code	B2
Filing date	Aug 27, 2021
Priority date	Sep 12, 2019
Publication date	May 24, 2022
Grant date	May 24, 2022

Abstract

The invention relates to the application of a composition containing recombinant amelogenin and propylene glycol alginate (“PGA”) on to cut dentin tubules followed by installation of a definitive restorative in a single visit.

First claim

The invention claimed is:

1. Tooth dental pulp treatment method for indirect or direct capping of a damaged tooth comprising:
applying a composition comprising amelogenin and propylene glycol alginate (“PGA”) to a surface of a pulp containing tooth comprising open dentinal tubules or exposed pulp, wherein the amelogenin comprises an amino acid sequence that is identical to the amino acid sequence of SEQ ID NO: 2, wherein 70-90% of a total number of carboxy groups of alginic acid forming the PGA are esterified; and
applying a permanent dental restorative on top of the applied composition comprising the amelogenin and the PGA.

2. The method of claim 1 , which is a method for indirect capping and wherein the composition is applied to the open dentinal tubules.

3. The method of claim 1 , which is a method of direct capping and the composition is applied to the exposed pulp.

4. The method of claim 1 , further comprising, after applying the composition, applying a permanent dental restorative on top of the applied composition within a span not exceeding 24 hours.

5. The method of claim 1 , wherein the tooth has been exposed to trauma associated with a dental procedure.

6. The method of claim 1 , wherein the composition consists of recombinant human amelogenin and a vehicle containing the propylene glycol alginate.

7. The method of claim 1 , wherein the composition further comprises a remineralization agent selected from the group consisting of a material providing calcium ions, a material providing phosphorous ions, and a material providing fluoride ions.

8. The method of claim 1 , wherein said composition further comprises at least one non-amelogenin enamel matrix protein.

Assignees

• Univ King Abdulaziz

Inventors

• Mounir Maha M F
• Bahammam Laila Ahmed Salim

Classifications

• A61K6/56 Primary

  Apical treatment · CPC title

• A61K6/898

  Polysaccharides · CPC title

• A61C5/77

  Methods or devices for making crowns · CPC title

• A61K38/39

  Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin, cold insoluble globulin [CIG] · CPC title

• A61K6/69

  Medicaments · CPC title