Magnetic resonance imaging of different nuclear spin species with the same radio frequency coil

Patent metadata

Field	Value
Publication number	US-11333729-B2
Application number	US-202017006249-A
Country	US
Kind code	B2
Filing date	Aug 28, 2020
Priority date	May 27, 2016
Publication date	May 17, 2022
Grant date	May 17, 2022

Abstract

Systems and methods for magnetic resonance imaging (“MRI”) of multiple different nuclear spin species using the same radio frequency (“RF”) coil are described. Generally, multiple different nuclear spin species are imaged using the same RF coil by using an MRI system whose magnetic field can be rapidly ramped between a number of different, and arbitrary, magnetic field strengths. The magnetic field of this MRI system can be ramped to different values in reasonable amounts of time (e.g., in a time frame that is feasible within an imaging study).

First claim

The invention claimed is:

1. A method for acquiring magnetic resonance data from different nuclear spin species with a magnetic resonance imaging (MRI) system, the steps of the method comprising:
acquiring first data from a first nuclear spin species in a subject and second data from a second nuclear spin species in the subject using the MRI system and a radio frequency (RF) coil tuned to a frequency band by:
(a) acquiring the first data from the first nuclear spin species using the RF coil tuned to the frequency band when a main magnetic field, B 0 , of the MRI system is at a first magnetic field strength at which a Larmor frequency corresponding to the first nuclear spin species is within the frequency band of the RF coil and the Larmor frequency corresponding to the second nuclear spin species is outside the frequency band of the RF coil;
(b) ramping the main magnetic field, B 0 , of the MRI system from the first magnetic field strength to a second magnetic field strength in order to shift the Larmor frequency corresponding to the second nuclear spin species into the frequency band of the RF coil; and
(c) acquiring the second data from the second nuclear spin species in the subject using the RF coil tuned to the frequency band when the main magnetic field, B 0 , of the MRI system is at the second magnetic field strength.

2. The method as recited in claim 1 , further comprising reconstructing a first image from the first data and reconstructing a second image from the second data, wherein the first image depicts the first nuclear spin species and the second image depicts the second nuclear spin species.

3. The method as recited in claim 1 , wherein the RF coil is a multichannel RF coil.

4. The method as recited in claim 1 , wherein the first nuclear spin species includes 1 H.

5. The method as recited in claim 4 , wherein the second nuclear spin species includes one of 3 He, 13 C, 19 F, 23 Na, 31 P, or 129 Xe.

6. The method as recited in claim 1 , wherein the first nuclear spin species is selected from the group consisting of 1 H, 3 He, 13 C, 19 F, 23 Na, 31 P, and 129 Xe, and the second nuclear spin species is selected from the group consisting of 1 H, 3 He, 13 C, 19 F, 23 Na, 31 P, and 129 Xe.

7. The method as recited in claim 1 , wherein the first magnetic field strength is 0.5 Tesla, and the frequency band of the RF coil spans a frequency range of 21 MHz to 23 MHz.

8. The method as recited in claim 7 , wherein the frequency band of the RF coil spans a frequency range of 21.5 Mhz to 22.5 MHz.

9. The method as recited in claim 1 , wherein the frequency band of the RF coil is at most 2 MHz.

10. The method as recited in claim 9 , wherein the frequency band of the RF coil is at most 1 MHz.

11. The method as recited in claim 1 , wherein the main magnetic field, B 0 , of the MRI system is ramped from the first magnetic field strength to the second magnetic field strength in less than 30 minutes.

12. The method as recited in claim 1 , wherein a position of the subject relative to the MRI system is not changed between acquiring the first data and acquiring the second data.

13. A method for acquiring magnetic resonance data from different nuclear spin species with a magnetic resonance imaging (MRI) system, the steps of the method comprising:
(a) acquiring first data from a first nuclear spin species in a subject and second data from a second nuclear spin species in the subject using the MRI system and a radio frequency (RF) coil tuned to a frequency band by:
(i) acquiring the first data from the first nuclear spin species using the RF coil tuned to the frequency band when a main magnetic field, B 0 , of the MRI system is at a first magnetic field strength at which a Larmor frequency corresponding to the first nuclear spin species is within the frequency band of the RF coil and the Larmor frequency corresponding to the second nuclear spin species is outside the frequency band of the RF coil;
(ii) ramping the main magnetic field, B 0 , of the MRI system from the first magnetic field strength to a second magnetic field strength in order to shift the Larmor frequency corresponding to the second nuclear spin species into the frequency band of the RF coil;
(iii) acquiring the second data from the second nuclear spin species in the subject using the RF coil tuned to the frequency band when the main magnetic field, B 0 , of the MRI system is at the second magnetic field strength

(b) reconstructing a first image from the first data and reconstructing a second image from the second data, wherein the first image depicts the first nuclear spin species and the second image depicts the second nuclear spin species; and
(c) generating a combined image by selectively combining the first image and the second image.

14. The method as recited in claim 13 , wherein the first nuclear spin species includes 1 H.

15. The method as recited in claim 14 , wherein the second nuclear spin species includes one of 3 He, 13 C, 19 F, 23 Na, 31 P, and 129 Xe.

16. The method as recited in claim 13 , wherein the first nuclear spin species is selected from the group consisting of 1 H, 3 He, 13 C, 19 F, 23 Na, 31 P, and 129 Xe, and the second nuclear spin species is selected from the group consisting of 1 H, 3 He, 13 C, 19 F, 23 Na, 31 P, and 129 Xe.

17. The method as recited in claim 13 , wherein the first magnetic field strength is 0.5 Tesla, and the frequency band of the RF coil spans a frequency range of 21 MHz to 23 MHz.

18. The method as recited in claim 17 , wherein the frequency band of the RF coil spans a frequency range of 21.5 Mhz to 22.5 MHz.

19. The method as recited in claim 13 , wherein the frequency band of the RF coil is at most 2 MHz.

20. The method as recited in claim 19 , wherein the frequency band of the RF coil is at most 1 MHz.

21. The method as recited in claim 13 , wherein the main magnetic field, B 0 , of the MRI system is ramped from the first magnetic field strength to the second magnetic field strength in less than 30 minutes.

Assignees

• Synaptive Medical Inc

Inventors

• Stainsby Jeff A

Classifications

• A61B5/055

  involving electronic [EMR] or nuclear [NMR] magnetic resonance, e.g. magnetic resonance imaging · CPC title

• G01R33/3635 Primary

  Multi-frequency operation · CPC title

• G01R33/445

  MR involving a non-standard magnetic field B0, e.g. of low magnitude as in the earth's magnetic field or in nanoTesla spectroscopy, comprising a polarizing magnetic field for pre-polarisation, B0 with a temporal variation of its magnitude or direction such as field cycling of B0 or rotation of the direction of B0, or spatially inhomogeneous B0 like in fringe-field MR or in stray-field imaging · CPC title

• G01R33/38

  Systems for generation, homogenisation or stabilisation of the main or gradient magnetic field · CPC title

• G01R33/54

  Signal processing systems, e.g. using pulse sequences {; Generation or control of pulse sequences; Operator console} · CPC title