Class of anti-adhesion hydrogels with healing aspects

Patent metadata

Field	Value
Publication number	US-11331408-B2
Application number	US-201816048280-A
Country	US
Kind code	B2
Filing date	Jul 29, 2018
Priority date	Jan 24, 2012
Publication date	May 17, 2022
Grant date	May 17, 2022

Abstract

Disclosed are hydrogels polymerized with a biofunctional moiety, biodegradable and permanent, designed to be implantable in a mammalian body and intended to block or mitigate the formation of tissue adhesions. The hydrogels of the present invention are characterized by comprising four structural elements: a) a polymeric backbone which defines the overall polymeric morphology, b) linkage groups, c) side chains, and d) biofunctional end groups. The hydrophobicity of the various structural elements are chosen to reduce tissue adhesion and enhance the biofunctional aspect of the end groups. The morphology of these polymers are typically of high molecular weight and have shape to encourage entanglement. Useful structures include branching chains, comb or brush, and dendritic morphologies.

First claim

What is claimed is:

1. A copolymeric hydrogel comprising a polymer backbone comprising at least one ester block and at least one ether block, wherein at least one side chain is bound to the polymer backbone,
wherein the at least one ester block is selected from the group consisting of polylactic acid, polycarbonate, polycaprolactone, polypropylene carbonate, polyvinyl acetate, and combinations thereof, the ester block having from 20 to 50 monomeric units,
wherein the at least one ether block is selected from the group consisting of polyethylene oxide, polypropylene oxide, polyvinyl ethers, and combinations thereof, wherein the ester block and ether block are in alternating positions in the polymer backbone, and
wherein the copolymeric hydrogel comprises at least 30% by weight of water bound to the hydrogel by hydrogen bonds.

2. The copolymeric hydrogel of claim 1 , wherein the hydrogel further comprises at least one polysaccharide group linked to a terminal end of the polymer backbone.

3. The copolymeric hydrogel of claim 2 , wherein the hydrogel further comprises boswellic acid bound to the polysaccharide group.

4. The copolymeric hydrogel of claim 2 , wherein the hydrogel further comprises boswellic acid bound to the polymer backbone.

5. The copolymeric hydrogel of claim 1 , wherein the hydrogel is polymer backbone is endcapped with boswellic acid.

6. The copolymer hydrogel of claim 1 , wherein the polymeric backbone further comprises a diisocyanate.

7. The copolymer hydrogel of claim 1 , wherein the at least one side chain selected from the group consisting of polysaccharide, D-mannuronate, and L-guluronate.

8. The copolymer hydrogel of claim 7 , wherein boswellic acid is bound to the side chain.

Assignees

• Bvw Holding Ag

Inventors

• Bluecher Lukas
• Milbocker Michael

Classifications

• C08G18/4833 Primary

  Polyethers containing oxyethylene units · CPC title

• C08G18/7621

  being toluene diisocyanate including isomer mixtures · CPC title

• A61K9/06

  Ointments; Bases therefor; {Other semi-solid forms, e.g. creams, sticks, gels (composition of ointments, creams or gels A61K47/00)} · CPC title

• A61L26/0019 Primary

  obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds · CPC title

• C08G18/2825

  having at least 6 carbon atoms · CPC title