Robotic Microtool Control in an Intelligent Automated In Vitro Fertilization and Intracytoplasmic Sperm Injection Platform
US-2024426856-A1 · Dec 26, 2024 · US
US11327088B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-11327088-B2 |
| Application number | US-201716076807-A |
| Country | US |
| Kind code | B2 |
| Filing date | Jan 13, 2017 |
| Priority date | Feb 19, 2016 |
| Publication date | May 10, 2022 |
| Grant date | May 10, 2022 |
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A reagent-bottle lid opening mechanism is disclosed, which has a needle for piercing a lid of a reagent bottle to be delivered to a reagent disk, has an aligning mechanism of automatically adjusting a position of the needle with respect to the lid such that a needle body of the needle can stick in the center of the lid, and accurately and repeatedly makes an incision in the center of the lid. As a result, an automatic analyzer is provided that is capable of unsealing the center of the lid of the reagent bottle with accuracy even if the central axis of the needle and the central axis of the lid are offset from each other.
Opening claim text (preview).
The invention claimed is: 1. A reagent bottle lid opening mechanism for use with an automatic analyzer that dispenses a sample and a reagent into each of multiple reaction containers, comprising: a reagent disk to hold reagent bottles containing the reagent; and a reagent-bottle lid opener comprising: a needle assembly comprising a needle body at a first end of the needle assembly to pierce a lid of the reagent bottle which has been entered into the automatic analyzer and is to be delivered to the reagent disk; a piercer supporter to adjust a position of the needle body with respect to the lid such that the needle body aligns with a center of the lid during piercing of the lid, wherein the piercer supporter is disposed at a second end of the needle assembly opposite of the needle body, the piercer supporter comprising: a piercer stopper with a larger diameter than the needle body, a piercer support supporting the piercer stopper such that the piercer stopper is movable in both a perpendicular and a parallel direction to a central axis of the needle assembly, and a retaining plate that is arranged above the piercer stopper in a vertical direction and limits the amount of movement of the piercer stopper in the parallel direction. 2. The reagent bottle lid opening mechanism according to claim 1 , wherein at least one of the piercer support and the piercer stopper is formed in a tapered shape. 3. The reagent bottle lid opening mechanism according to claim 2 , wherein the piercer supporter further comprises: the piercer support of a tapered shape in contact with the piercer stopper; a support plate supporting the piercer support, wherein a clearance between an opening formed in the piercer supporter and the piercer shaft of the needle assembly and a clearance between a side face of the piercer stopper and a side face of the piercer support are each greater than a difference between a central axis of the lid and a central axis of the needle body. 4. The reagent bottle lid opening mechanism according to claim 3 , wherein the needle assembly further comprises: a piercer shaft supporting the needle body; a piercer guide covering the needle body; and a spring placed within the piercer guide to press the needle body toward the piercer shaft, wherein upon contact between the piercer stopper and the retaining plate, the spring contracts and the needle body contacts the lid. 5. The reagent bottle lid opening mechanism according to claim 4 , wherein the piercer guide has a tapered portion, wherein the tapered portion of the piercer guide contacts a tapered portion of the lid to align the needle body with the center of the lid. 6. The reagent bottle lid opening mechanism according to claim 1 , wherein the piercer supporter comprises: a plurality of balls in contact with the piercer stopper; and a support plate to hold the balls. 7. The reagent bottle lid opening mechanism according to claim 1 , wherein the needle assembly travels from an original position to a piercing position during piercing of the lid; and the needle assembly automatically moves back to the original position after piercing the lid. 8. The reagent bottle lid opening mechanism according to claim 1 , further comprising: a reagent loading tray to receive the reagent bottles at the automatic analyzer and to place the received reagent bottles; and a reagent transferor to transfer the reagent bottle placed in the reagent loading tray into the reagent disk, the reagent transferor comprising: a gripper to grip the reagent bottle. 9. The reagent bottle lid opening mechanism according to claim 4 , wherein the reagent-bottle lid opener comprises a piercer shaft guide to guide the piercer shaft. 10. The reagent bottle lid opening mechanism according to claim 5 , wherein the reagent-bottle comprises a plurality of lids, and the reagent-bottle lid opener comprises a plurality of needle bodies. 11. The reagent bottle lid opening mechanism according to claim 8 , wherein the reagent loading tray comprises one or more reagent slots for installing a reagent-bottle, and in a case where an empty reagent-bottle is discharged from the reagent disk when a reagent-bottle to be loaded into the analyzer is installed in all the reagent slots, the reagent transferor is configured to: load the reagent-bottle placed on the reagent loading tray into the reagent disk without making an incision in the lid of the reagent-bottle and carry the empty reagent-bottle to the reagent slot. 12. The reagent bottle lid opening mechanism according to claim 11 , wherein, in a case that there is a vacant reagent slot, the reagent transferor carries the reagent-bottle, which was loaded into the reagent disk without making the incision in the lid, into the vacant reagent slot.
Control of the position or alignment of the transfer device · CPC title
Combinations of the above · CPC title
having a carousel or turntable for reaction cells or cuvettes · CPC title
for reagents · CPC title
manipulating closing or opening means, e.g. stoppers, screw caps, lids or covers · CPC title
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