Compounds and methods for treating cancer

Patent metadata

Field	Value
Publication number	US-11325892-B2
Application number	US-201916422519-A
Country	US
Kind code	B2
Filing date	May 24, 2019
Priority date	Aug 7, 2014
Publication date	May 10, 2022
Grant date	May 10, 2022

Abstract

This document provides compounds, compositions, and methods for treating cancers including renal cancer (e.g., renal cell carcinoma) as well as ovarian, breast, prostate, colon, pancreatic, bladder, liver, lung, and thyroid cancers and melanoma. For example, compounds, compositions, and methods for using one or more inhibitors of SCD1 to treat renal cell carcinoma (e.g., clear cell renal cell carcinoma (ccRCC)), thyroid cancer, or liver cancer; or to increase the efficacy of treatment for the same.

First claim

What is claimed is:

1. A compound according to Formula (II):

or a pharmaceutically acceptable salt thereof,
wherein
R 1 is halo;
X is —(C═O)NR 4 —;
Y is

and
R 2 , R 3 , and R 4 are each independently H or an unsubstituted C 1-6 alkyl.

2. The compound of claim 1 , wherein the compound according to Formula (II) has the structure of Formula (IIa):

or a pharmaceutically acceptable salt thereof.

3. The compound of claim 1 , wherein R 1 is Cl.

4. The compound of claim 1 , wherein R 4 is H.

5. The compound of claim 1 , wherein R 2 is H and R 3 is CH 3 .

6. The compound of claim 1 , wherein the compound according to Formula (II) is

or a pharmaceutically acceptable salt thereof.

7. A pharmaceutical composition comprising a compound, or a pharmaceutically acceptable salt thereof, according to claim 1 , and a pharmaceutically acceptable carrier.

Assignees

• Mayo Found Medical Education & Res

Inventors

• Copland Iii John A
• Tun Han W
• Caulfield Thomas R
• Von Roemeling Christina
• Marlow Laura Ann

Classifications

• C07D213/64

  attached in position 2 or 6 · CPC title

• A61K31/496

  Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin · CPC title

• C07D211/66

  having a hetero atom as the second substituent in position 4 · CPC title

• A61K45/06

  Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca · CPC title

• C07D295/192 Primary

  from aromatic carboxylic acids · CPC title